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YidC as an essential and multifunctional component in membrane protein assembly.
Int Rev Cytol 2007; 259:113-38IR

Abstract

Membrane proteins fulfill a number of vital functions in prokaryotic and eukaryotic cells. They are often organized in multicomponent complexes, folded within the membrane bilayer and interacting with the cytoplasmic and periplasmic or external soluble compartments. For the biogenesis of integral membrane proteins, the essential biochemical steps are (1) the insertion and topogenesis of the transmembrane protein segments into the lipid bilayer, (2) the three-dimensional folding of the translocated hydrophilic domains, and (3) the assembly into multimeric complexes. Intensive research has elucidated the basic mechanisms of membrane protein insertion in the homologous translocation machineries of different cellular systems. Whereas the Sec translocation system is found in the endoplasmic reticulum of eukaryotic cells and in the prokaryotic plasma membrane, the YidC-Oxa1 membrane insertase is present in prokaryotic and organellar membranes. This review focuses on the discoveries of the YidC system in bacterial as well as the Oxa1/Alb3 protein family of eukaryotic cells and will particularly emphasize evolutionary aspects.

Authors+Show Affiliations

Department of Microbiology, University of Hohenheim, D-70599 Stuttgart, Germany.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17425940

Citation

Kiefer, Dorothee, and Andreas Kuhn. "YidC as an Essential and Multifunctional Component in Membrane Protein Assembly." International Review of Cytology, vol. 259, 2007, pp. 113-38.
Kiefer D, Kuhn A. YidC as an essential and multifunctional component in membrane protein assembly. Int Rev Cytol. 2007;259:113-38.
Kiefer, D., & Kuhn, A. (2007). YidC as an essential and multifunctional component in membrane protein assembly. International Review of Cytology, 259, pp. 113-38.
Kiefer D, Kuhn A. YidC as an Essential and Multifunctional Component in Membrane Protein Assembly. Int Rev Cytol. 2007;259:113-38. PubMed PMID: 17425940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - YidC as an essential and multifunctional component in membrane protein assembly. AU - Kiefer,Dorothee, AU - Kuhn,Andreas, PY - 2007/4/12/pubmed PY - 2007/5/26/medline PY - 2007/4/12/entrez SP - 113 EP - 38 JF - International review of cytology JO - Int. Rev. Cytol. VL - 259 N2 - Membrane proteins fulfill a number of vital functions in prokaryotic and eukaryotic cells. They are often organized in multicomponent complexes, folded within the membrane bilayer and interacting with the cytoplasmic and periplasmic or external soluble compartments. For the biogenesis of integral membrane proteins, the essential biochemical steps are (1) the insertion and topogenesis of the transmembrane protein segments into the lipid bilayer, (2) the three-dimensional folding of the translocated hydrophilic domains, and (3) the assembly into multimeric complexes. Intensive research has elucidated the basic mechanisms of membrane protein insertion in the homologous translocation machineries of different cellular systems. Whereas the Sec translocation system is found in the endoplasmic reticulum of eukaryotic cells and in the prokaryotic plasma membrane, the YidC-Oxa1 membrane insertase is present in prokaryotic and organellar membranes. This review focuses on the discoveries of the YidC system in bacterial as well as the Oxa1/Alb3 protein family of eukaryotic cells and will particularly emphasize evolutionary aspects. SN - 0074-7696 UR - https://www.unboundmedicine.com/medline/citation/17425940/YidC_as_an_essential_and_multifunctional_component_in_membrane_protein_assembly_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0074-7696(06)59003-5 DB - PRIME DP - Unbound Medicine ER -