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Diverse molecular data demonstrate that commercially available medicinal leeches are not Hirudo medicinalis.
Proc Biol Sci. 2007 Jun 22; 274(1617):1481-7.PB

Abstract

The European medicinal leech is one of vanishingly few animal species with direct application in modern medicine. In addition to the therapeutic potential held by many protease inhibitors purified from leech saliva, and notwithstanding the historical association with quackery, Hirudo medicinalis has been approved by the United States Food and Drug Administration as a prescription medical device. Accurate annotation of bioactive compounds relies on precise species determination. Interpretations of developmental and neurophysiological characteristics also presuppose uniformity within a model species used in laboratory settings. Here, we show, with mitochondrial sequences and nuclear microsatellites, that there are at least three species of European medicinal leech, and that leeches marketed as H. medicinalis are actually Hirudo verbana. Beyond the obvious need for reconsideration of decades of biomedical research on this widely used model organism, these findings impact regulatory statutes and raise concerns for the conservation status of European medicinal leeches.

Authors+Show Affiliations

Division of Invertebrate Zoology, American Museum of Natural History, New York, NY 10024, USA. siddall@amnh.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17426015

Citation

Siddall, Mark E., et al. "Diverse Molecular Data Demonstrate That Commercially Available Medicinal Leeches Are Not Hirudo Medicinalis." Proceedings. Biological Sciences, vol. 274, no. 1617, 2007, pp. 1481-7.
Siddall ME, Trontelj P, Utevsky SY, et al. Diverse molecular data demonstrate that commercially available medicinal leeches are not Hirudo medicinalis. Proc Biol Sci. 2007;274(1617):1481-7.
Siddall, M. E., Trontelj, P., Utevsky, S. Y., Nkamany, M., & Macdonald, K. S. (2007). Diverse molecular data demonstrate that commercially available medicinal leeches are not Hirudo medicinalis. Proceedings. Biological Sciences, 274(1617), 1481-7.
Siddall ME, et al. Diverse Molecular Data Demonstrate That Commercially Available Medicinal Leeches Are Not Hirudo Medicinalis. Proc Biol Sci. 2007 Jun 22;274(1617):1481-7. PubMed PMID: 17426015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diverse molecular data demonstrate that commercially available medicinal leeches are not Hirudo medicinalis. AU - Siddall,Mark E, AU - Trontelj,Peter, AU - Utevsky,Serge Y, AU - Nkamany,Mary, AU - Macdonald,Kenneth S, PY - 2007/4/12/pubmed PY - 2008/1/9/medline PY - 2007/4/12/entrez SP - 1481 EP - 7 JF - Proceedings. Biological sciences JO - Proc. Biol. Sci. VL - 274 IS - 1617 N2 - The European medicinal leech is one of vanishingly few animal species with direct application in modern medicine. In addition to the therapeutic potential held by many protease inhibitors purified from leech saliva, and notwithstanding the historical association with quackery, Hirudo medicinalis has been approved by the United States Food and Drug Administration as a prescription medical device. Accurate annotation of bioactive compounds relies on precise species determination. Interpretations of developmental and neurophysiological characteristics also presuppose uniformity within a model species used in laboratory settings. Here, we show, with mitochondrial sequences and nuclear microsatellites, that there are at least three species of European medicinal leech, and that leeches marketed as H. medicinalis are actually Hirudo verbana. Beyond the obvious need for reconsideration of decades of biomedical research on this widely used model organism, these findings impact regulatory statutes and raise concerns for the conservation status of European medicinal leeches. SN - 0962-8452 UR - https://www.unboundmedicine.com/medline/citation/17426015/Diverse_molecular_data_demonstrate_that_commercially_available_medicinal_leeches_are_not_Hirudo_medicinalis_ L2 - https://royalsocietypublishing.org/doi/full/10.1098/rspb.2007.0248?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -