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Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand.
Am J Trop Med Hyg. 2007 Apr; 76(4):655-8.AJ

Abstract

A combination of atovaquone-proguanil (Malarone); GlaxoSmithKline, Research Triangle Park, NC) was previously shown to be highly effective in the treatment of uncomplicated Plasmodium falciparum malaria. However, there are only limited recent efficacy data, particularly from regions of multidrug resistance. In this study, we examined the efficacy of atovaquone-proguanil for the treatment of uncomplicated P. falciparum malaria on the Thailand-Myanmar border. Patients were given directly observed atovaquone-proguanil (1,000 mg/400 mg) once a day for three days and followed-up for four weeks in a non-transmission area. Of 140 eligible patients enrolled in this open-label study, 97.8% (95% confidence interval = 95.4-100%) responded to therapy and remained clear of parasitemia at follow-up. Mean parasite clearance time was 41.9 hours and mean fever clearance time was 37.1 hours. On the basis of genotyping, three cases of treatment failure were identified (1 RIII and 2 RI). These data indicate that atovaquone-proguanil remains highly efficacious for the treatment of multidrug-resistant P. falciparum malaria in Thailand.

Authors+Show Affiliations

Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17426165

Citation

Krudsood, Srivicha, et al. "Efficacy of Atovaquone-proguanil for Treatment of Acute Multidrug-resistant Plasmodium Falciparum Malaria in Thailand." The American Journal of Tropical Medicine and Hygiene, vol. 76, no. 4, 2007, pp. 655-8.
Krudsood S, Patel SN, Tangpukdee N, et al. Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg. 2007;76(4):655-8.
Krudsood, S., Patel, S. N., Tangpukdee, N., Thanachartwet, W., Leowattana, W., Pornpininworakij, K., Boggild, A. K., Looareesuwan, S., & Kain, K. C. (2007). Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand. The American Journal of Tropical Medicine and Hygiene, 76(4), 655-8.
Krudsood S, et al. Efficacy of Atovaquone-proguanil for Treatment of Acute Multidrug-resistant Plasmodium Falciparum Malaria in Thailand. Am J Trop Med Hyg. 2007;76(4):655-8. PubMed PMID: 17426165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand. AU - Krudsood,Srivicha, AU - Patel,Samir N, AU - Tangpukdee,Nopaddon, AU - Thanachartwet,Wipa, AU - Leowattana,Wattana, AU - Pornpininworakij,Karnchana, AU - Boggild,Andrea K, AU - Looareesuwan,Sornchai, AU - Kain,Kevin C, PY - 2007/4/12/pubmed PY - 2007/5/24/medline PY - 2007/4/12/entrez SP - 655 EP - 8 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 76 IS - 4 N2 - A combination of atovaquone-proguanil (Malarone); GlaxoSmithKline, Research Triangle Park, NC) was previously shown to be highly effective in the treatment of uncomplicated Plasmodium falciparum malaria. However, there are only limited recent efficacy data, particularly from regions of multidrug resistance. In this study, we examined the efficacy of atovaquone-proguanil for the treatment of uncomplicated P. falciparum malaria on the Thailand-Myanmar border. Patients were given directly observed atovaquone-proguanil (1,000 mg/400 mg) once a day for three days and followed-up for four weeks in a non-transmission area. Of 140 eligible patients enrolled in this open-label study, 97.8% (95% confidence interval = 95.4-100%) responded to therapy and remained clear of parasitemia at follow-up. Mean parasite clearance time was 41.9 hours and mean fever clearance time was 37.1 hours. On the basis of genotyping, three cases of treatment failure were identified (1 RIII and 2 RI). These data indicate that atovaquone-proguanil remains highly efficacious for the treatment of multidrug-resistant P. falciparum malaria in Thailand. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/17426165/Efficacy_of_atovaquone_proguanil_for_treatment_of_acute_multidrug_resistant_Plasmodium_falciparum_malaria_in_Thailand_ L2 - http://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -