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Monkeypox zoonotic associations: insights from laboratory evaluation of animals associated with the multi-state US outbreak.
Am J Trop Med Hyg. 2007 Apr; 76(4):757-68.AJ

Abstract

At the onset of the 2003 US monkeypox outbreak, virologic data were unavailable regarding which animal species were involved with virus importation and/or subsequent transmission to humans and whether there was a risk for establishment of zoonotic monkeypox in North America. Similarly, it was unclear which specimens would be best for virus testing. Monkeypox DNA was detected in at least 33 animals, and virus was cultured from 22. Virus-positive animals included three African species associated with the importation event (giant pouched rats, Cricetomys spp.; rope squirrels, Funisciuris sp.; and dormice, Graphiuris sp.). Virologic evidence from North American prairie dogs (Cynomys sp.) was concordant with their suspected roles as vectors for human monkeypox. Multiple tissues were found suitable for DNA detection and/or virus isolation. These data extend the potential host range for monkeypox virus infection and supports concern regarding the potential for establishment in novel reservoir species and ecosystems.

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Authors+Show Affiliations

Hutson CL
Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Lee KN
No affiliation info available
Abel J
No affiliation info available
Carroll DS
No affiliation info available
Montgomery JM
No affiliation info available
Olson VA
No affiliation info available
Li Y
No affiliation info available
Davidson W
No affiliation info available
Hughes C
No affiliation info available
Dillon M
No affiliation info available
Spurlock P
No affiliation info available
Kazmierczak JJ
No affiliation info available
Austin C
No affiliation info available
Miser L
No affiliation info available
Sorhage FE
No affiliation info available
Howell J
No affiliation info available
Davis JP
No affiliation info available
Reynolds MG
No affiliation info available
Braden Z
No affiliation info available
Karem KL
No affiliation info available
Damon IK
No affiliation info available
Regnery RL
No affiliation info available

MeSH

AnimalsDNA, ViralDisease OutbreaksHedgehogsHerpestidaeMacropodidaeMonkeypoxMonkeypox virusMonodelphisRaccoonsRodentiaUnited StatesZoonoses

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17426184

Citation

Hutson, Christina L., et al. "Monkeypox Zoonotic Associations: Insights From Laboratory Evaluation of Animals Associated With the Multi-state US Outbreak." The American Journal of Tropical Medicine and Hygiene, vol. 76, no. 4, 2007, pp. 757-68.
Hutson CL, Lee KN, Abel J, et al. Monkeypox zoonotic associations: insights from laboratory evaluation of animals associated with the multi-state US outbreak. Am J Trop Med Hyg. 2007;76(4):757-68.
Hutson, C. L., Lee, K. N., Abel, J., Carroll, D. S., Montgomery, J. M., Olson, V. A., Li, Y., Davidson, W., Hughes, C., Dillon, M., Spurlock, P., Kazmierczak, J. J., Austin, C., Miser, L., Sorhage, F. E., Howell, J., Davis, J. P., Reynolds, M. G., Braden, Z., ... Regnery, R. L. (2007). Monkeypox zoonotic associations: insights from laboratory evaluation of animals associated with the multi-state US outbreak. The American Journal of Tropical Medicine and Hygiene, 76(4), 757-68.
Hutson CL, et al. Monkeypox Zoonotic Associations: Insights From Laboratory Evaluation of Animals Associated With the Multi-state US Outbreak. Am J Trop Med Hyg. 2007;76(4):757-68. PubMed PMID: 17426184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monkeypox zoonotic associations: insights from laboratory evaluation of animals associated with the multi-state US outbreak. AU - Hutson,Christina L, AU - Lee,Kemba N, AU - Abel,Jason, AU - Carroll,Darin S, AU - Montgomery,Joel M, AU - Olson,Victoria A, AU - Li,Yu, AU - Davidson,Whitni, AU - Hughes,Christine, AU - Dillon,Michael, AU - Spurlock,Paul, AU - Kazmierczak,James J, AU - Austin,Connie, AU - Miser,Lori, AU - Sorhage,Faye E, AU - Howell,James, AU - Davis,Jeffrey P, AU - Reynolds,Mary G, AU - Braden,Zachary, AU - Karem,Kevin L, AU - Damon,Inger K, AU - Regnery,Russell L, PY - 2007/4/12/pubmed PY - 2007/5/24/medline PY - 2007/4/12/entrez SP - 757 EP - 68 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 76 IS - 4 N2 - At the onset of the 2003 US monkeypox outbreak, virologic data were unavailable regarding which animal species were involved with virus importation and/or subsequent transmission to humans and whether there was a risk for establishment of zoonotic monkeypox in North America. Similarly, it was unclear which specimens would be best for virus testing. Monkeypox DNA was detected in at least 33 animals, and virus was cultured from 22. Virus-positive animals included three African species associated with the importation event (giant pouched rats, Cricetomys spp.; rope squirrels, Funisciuris sp.; and dormice, Graphiuris sp.). Virologic evidence from North American prairie dogs (Cynomys sp.) was concordant with their suspected roles as vectors for human monkeypox. Multiple tissues were found suitable for DNA detection and/or virus isolation. These data extend the potential host range for monkeypox virus infection and supports concern regarding the potential for establishment in novel reservoir species and ecosystems. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/17426184/Monkeypox_zoonotic_associations:_insights_from_laboratory_evaluation_of_animals_associated_with_the_multi_state_US_outbreak_ L2 - https://medlineplus.gov/animaldiseasesandyourhealth.html DB - PRIME DP - Unbound Medicine ER -