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Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone.
Digestion. 2007; 75(1):10-6.D

Abstract

BACKGROUND

Patients with Crohn's disease (CD) often develop malnutrition due to disease activity. We aimed to assess the effect of two different enteral supplements of Impact(R) Powder (IP; Novartis, Switzerland) on leptin levels and nutritional status in active CD patients during prednisolone treatment and tapering.

METHODS

Thirty-one CD patients were randomized to IP Extra (group 1) or IP Standard (group 2). Leptin levels, nutritional, clinical and biochemical markers were studied at inclusion, after 5 and after 9 weeks of the study.

RESULTS

Leptin levels, body mass index (BMI) and total cholesterol increased significantly within both groups at week 5 compared to inclusion. Leptin levels correlated with BMI in both groups at inclusion and in group 2 at week 9. In group 1, triglyceride levels remained unchanged, while levels in group 2 increased significantly at week 5 compared to inclusion. Clinical and biochemical markers improved during the study compared to inclusion.

CONCLUSIONS

Increased leptin levels during the study progress were transient, decreasing due to prednisolone withdrawal at the end of the study. Both formulas used as adjuvant therapy to prednisolone treatment were able to improve nutritional status in CD patients.

Authors+Show Affiliations

Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark. anenie@vgs.vejleamt.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17429201

Citation

Nielsen, Aneta Aleksandra, et al. "Impact of Enteral Supplements Enriched With Omega-3 Fatty Acids And/or Omega-6 Fatty Acids, Arginine and Ribonucleic Acid Compounds On Leptin Levels and Nutritional Status in Active Crohn's Disease Treated With Prednisolone." Digestion, vol. 75, no. 1, 2007, pp. 10-6.
Nielsen AA, Nielsen JN, Grønbaek H, et al. Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone. Digestion. 2007;75(1):10-6.
Nielsen, A. A., Nielsen, J. N., Grønbaek, H., Eivindson, M., Vind, I., Munkholm, P., Brandslund, I., & Hey, H. (2007). Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone. Digestion, 75(1), 10-6.
Nielsen AA, et al. Impact of Enteral Supplements Enriched With Omega-3 Fatty Acids And/or Omega-6 Fatty Acids, Arginine and Ribonucleic Acid Compounds On Leptin Levels and Nutritional Status in Active Crohn's Disease Treated With Prednisolone. Digestion. 2007;75(1):10-6. PubMed PMID: 17429201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone. AU - Nielsen,Aneta Aleksandra, AU - Nielsen,Jens Nederby, AU - Grønbaek,Henning, AU - Eivindson,Martin, AU - Vind,Ida, AU - Munkholm,Pia, AU - Brandslund,Ivan, AU - Hey,Henrik, Y1 - 2007/04/10/ PY - 2006/08/23/received PY - 2006/12/28/accepted PY - 2007/4/13/pubmed PY - 2007/5/22/medline PY - 2007/4/13/entrez SP - 10 EP - 6 JF - Digestion JO - Digestion VL - 75 IS - 1 N2 - BACKGROUND: Patients with Crohn's disease (CD) often develop malnutrition due to disease activity. We aimed to assess the effect of two different enteral supplements of Impact(R) Powder (IP; Novartis, Switzerland) on leptin levels and nutritional status in active CD patients during prednisolone treatment and tapering. METHODS: Thirty-one CD patients were randomized to IP Extra (group 1) or IP Standard (group 2). Leptin levels, nutritional, clinical and biochemical markers were studied at inclusion, after 5 and after 9 weeks of the study. RESULTS: Leptin levels, body mass index (BMI) and total cholesterol increased significantly within both groups at week 5 compared to inclusion. Leptin levels correlated with BMI in both groups at inclusion and in group 2 at week 9. In group 1, triglyceride levels remained unchanged, while levels in group 2 increased significantly at week 5 compared to inclusion. Clinical and biochemical markers improved during the study compared to inclusion. CONCLUSIONS: Increased leptin levels during the study progress were transient, decreasing due to prednisolone withdrawal at the end of the study. Both formulas used as adjuvant therapy to prednisolone treatment were able to improve nutritional status in CD patients. SN - 1421-9867 UR - https://www.unboundmedicine.com/medline/citation/17429201/Impact_of_enteral_supplements_enriched_with_omega_3_fatty_acids_and/or_omega_6_fatty_acids_arginine_and_ribonucleic_acid_compounds_on_leptin_levels_and_nutritional_status_in_active_Crohn's_disease_treated_with_prednisolone_ L2 - https://www.karger.com?DOI=10.1159/000101560 DB - PRIME DP - Unbound Medicine ER -