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Vaporization as a smokeless cannabis delivery system: a pilot study.
Clin Pharmacol Ther. 2007 Nov; 82(5):572-8.CP

Abstract

Although cannabis may have potential therapeutic value, inhalation of a combustion product is an undesirable delivery system. The aim of the study was to investigate vaporization using the Volcano((R)) device as an alternative means of delivery of inhaled Cannabis sativa. Eighteen healthy inpatient subjects enrolled to compare the delivery of cannabinoids by vaporization to marijuana smoked in a standard cigarette. One strength (1.7, 3.4, or 6.8% tetrahydrocannabinol (THC)) and delivery system was randomly assigned for each of the 6 study days. Plasma concentrations of Delta-9-THC, expired carbon monoxide (CO), physiologic and neuropsychologic effects were the main outcome measures. Peak plasma concentrations and 6-h area under the plasma concentration-time curve of THC were similar. CO levels were reduced with vaporization. No adverse events occurred. Vaporization of cannabis is a safe and effective mode of delivery of THC. Further trials of clinical effectiveness of cannabis could utilize vaporization as a smokeless delivery system.

Authors+Show Affiliations

Community Consortium, Positive Health Program, San Francisco General Hospital, San Francisco, California, USA. dabrams@php.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17429350

Citation

Abrams, D I., et al. "Vaporization as a Smokeless Cannabis Delivery System: a Pilot Study." Clinical Pharmacology and Therapeutics, vol. 82, no. 5, 2007, pp. 572-8.
Abrams DI, Vizoso HP, Shade SB, et al. Vaporization as a smokeless cannabis delivery system: a pilot study. Clin Pharmacol Ther. 2007;82(5):572-8.
Abrams, D. I., Vizoso, H. P., Shade, S. B., Jay, C., Kelly, M. E., & Benowitz, N. L. (2007). Vaporization as a smokeless cannabis delivery system: a pilot study. Clinical Pharmacology and Therapeutics, 82(5), 572-8.
Abrams DI, et al. Vaporization as a Smokeless Cannabis Delivery System: a Pilot Study. Clin Pharmacol Ther. 2007;82(5):572-8. PubMed PMID: 17429350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaporization as a smokeless cannabis delivery system: a pilot study. AU - Abrams,D I, AU - Vizoso,H P, AU - Shade,S B, AU - Jay,C, AU - Kelly,M E, AU - Benowitz,N L, Y1 - 2007/04/11/ PY - 2007/4/13/pubmed PY - 2007/12/6/medline PY - 2007/4/13/entrez SP - 572 EP - 8 JF - Clinical pharmacology and therapeutics JO - Clin Pharmacol Ther VL - 82 IS - 5 N2 - Although cannabis may have potential therapeutic value, inhalation of a combustion product is an undesirable delivery system. The aim of the study was to investigate vaporization using the Volcano((R)) device as an alternative means of delivery of inhaled Cannabis sativa. Eighteen healthy inpatient subjects enrolled to compare the delivery of cannabinoids by vaporization to marijuana smoked in a standard cigarette. One strength (1.7, 3.4, or 6.8% tetrahydrocannabinol (THC)) and delivery system was randomly assigned for each of the 6 study days. Plasma concentrations of Delta-9-THC, expired carbon monoxide (CO), physiologic and neuropsychologic effects were the main outcome measures. Peak plasma concentrations and 6-h area under the plasma concentration-time curve of THC were similar. CO levels were reduced with vaporization. No adverse events occurred. Vaporization of cannabis is a safe and effective mode of delivery of THC. Further trials of clinical effectiveness of cannabis could utilize vaporization as a smokeless delivery system. SN - 1532-6535 UR - https://www.unboundmedicine.com/medline/citation/17429350/Vaporization_as_a_smokeless_cannabis_delivery_system:_a_pilot_study_ L2 - https://doi.org/10.1038/sj.clpt.6100200 DB - PRIME DP - Unbound Medicine ER -