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Pharmacologic modulation of sebaceous gland activity: mechanisms and clinical applications.
Dermatol Clin. 2007 Apr; 25(2):137-46, v.DC

Abstract

Acne vulgaris is a common skin condition seen by physicians. It primarily affects adolescents, but can continue into adulthood. A key factor in the pathogenesis of acne is sebum production. Typical therapy includes combinations of topical retinoids and antimicrobials for mild acne, with the addition of oral antibiotics for moderate to severe disease. In the most recalcitrant cases or for nodulocystic acne, oral retinoids are indicated. In women who fail to respond to conventional treatment, hormonal therapy is often used adjunctively. Only isotretinoin and hormonal therapy improve acne via their action on the sebaceous glands. This article focuses on the mechanisms by which these treatment modalities act on the sebaceous glands and their clinical use in the practice of medicine.

Authors+Show Affiliations

The Department of Dermatology, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, PA 17033, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17430751

Citation

Clarke, Shari B., et al. "Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications." Dermatologic Clinics, vol. 25, no. 2, 2007, pp. 137-46, v.
Clarke SB, Nelson AM, George RE, et al. Pharmacologic modulation of sebaceous gland activity: mechanisms and clinical applications. Dermatol Clin. 2007;25(2):137-46, v.
Clarke, S. B., Nelson, A. M., George, R. E., & Thiboutot, D. M. (2007). Pharmacologic modulation of sebaceous gland activity: mechanisms and clinical applications. Dermatologic Clinics, 25(2), 137-46, v.
Clarke SB, et al. Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications. Dermatol Clin. 2007;25(2):137-46, v. PubMed PMID: 17430751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacologic modulation of sebaceous gland activity: mechanisms and clinical applications. AU - Clarke,Shari B, AU - Nelson,Amanda M, AU - George,Rosalyn E, AU - Thiboutot,Diane M, PY - 2007/4/14/pubmed PY - 2007/6/30/medline PY - 2007/4/14/entrez SP - 137-46, v JF - Dermatologic clinics JO - Dermatol Clin VL - 25 IS - 2 N2 - Acne vulgaris is a common skin condition seen by physicians. It primarily affects adolescents, but can continue into adulthood. A key factor in the pathogenesis of acne is sebum production. Typical therapy includes combinations of topical retinoids and antimicrobials for mild acne, with the addition of oral antibiotics for moderate to severe disease. In the most recalcitrant cases or for nodulocystic acne, oral retinoids are indicated. In women who fail to respond to conventional treatment, hormonal therapy is often used adjunctively. Only isotretinoin and hormonal therapy improve acne via their action on the sebaceous glands. This article focuses on the mechanisms by which these treatment modalities act on the sebaceous glands and their clinical use in the practice of medicine. SN - 0733-8635 UR - https://www.unboundmedicine.com/medline/citation/17430751/Pharmacologic_modulation_of_sebaceous_gland_activity:_mechanisms_and_clinical_applications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0733-8635(07)00005-8 DB - PRIME DP - Unbound Medicine ER -