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Metabolic syndrome and the risk of ischemic heart disease and stroke among Japanese men and women.
Stroke 2007; 38(6):1744-51S

Abstract

BACKGROUND AND PURPOSE

Limited evidence was available on the metabolic syndrome and risk of cardiovascular disease in Asia. The purpose of this study is to examine the association of the metabolic syndrome and risk of ischemic cardiovascular disease in Japanese men and women.

METHODS

We conducted an 18-year prospective study of 9087 Japanese people aged 40 to 69 years (3595 men and 5492 women), initially free of ischemic heart disease or stroke. During follow-up, there were 116 (74 men and 42 women) cases of ischemic heart disease and 256 (144 men and 112 women) ischemic strokes. Metabolic syndrome was defined by the modified criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATPIII), with the presence of >/=3 of the following factors: (1) serum triglycerides >/=1.69 mmol/L (150 mg/dL); (2) HDL-cholesterol <1.03 mmol/L (40 mg/dL) for men and <1.29 mmol/L (50 mg/dL) for women; (3) glucose >/=6.11 mmol/L (110 mg/dL) fasting or >/=7.77 mmol/L (140 mg/dL) nonfasting, or on treatment; (4) blood pressure > or =130/85 mm Hg or medication use, and (5) body mass index >/=25.0 kg/m(2).

RESULTS

For both sexes, high blood pressure, high triglycerides and low HDL cholesterol were associated with increased risks of ischemic heart disease or stroke after adjustment for cardiovascular risk factors. A dose-response relationship was found between the number of metabolic risk factors and incidence of these cardiovascular end points. The multivariable hazard ratio (95% CI) associated with metabolic syndrome was 2.4 (1.4 to 4.0) in men and 2.3 (1.2 to 4.3) in women for ischemic heart disease, and 2.0 (1.3 to 3.1) and 1.5 (1.0 to 2.3), respectively, for ischemic stroke. The contribution of metabolic syndrome to the risks was independent of serum total cholesterol levels but stronger among smokers.

CONCLUSIONS

The metabolic syndrome is a major determinant of ischemic cardiovascular disease among middle-aged Japanese men and women, in particular among smokers.

Authors+Show Affiliations

Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Osaka-fu, Japan. iso@pbhel.med.osaka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17431205

Citation

Iso, Hiroyasu, et al. "Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke Among Japanese Men and Women." Stroke, vol. 38, no. 6, 2007, pp. 1744-51.
Iso H, Sato S, Kitamura A, et al. Metabolic syndrome and the risk of ischemic heart disease and stroke among Japanese men and women. Stroke. 2007;38(6):1744-51.
Iso, H., Sato, S., Kitamura, A., Imano, H., Kiyama, M., Yamagishi, K., ... Shimamoto, T. (2007). Metabolic syndrome and the risk of ischemic heart disease and stroke among Japanese men and women. Stroke, 38(6), pp. 1744-51.
Iso H, et al. Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke Among Japanese Men and Women. Stroke. 2007;38(6):1744-51. PubMed PMID: 17431205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and the risk of ischemic heart disease and stroke among Japanese men and women. AU - Iso,Hiroyasu, AU - Sato,Shinichi, AU - Kitamura,Akihiko, AU - Imano,Hironori, AU - Kiyama,Masahiko, AU - Yamagishi,Kazumasa, AU - Cui,Renzhe, AU - Tanigawa,Takeshi, AU - Shimamoto,Takashi, Y1 - 2007/04/12/ PY - 2007/4/14/pubmed PY - 2007/6/15/medline PY - 2007/4/14/entrez SP - 1744 EP - 51 JF - Stroke JO - Stroke VL - 38 IS - 6 N2 - BACKGROUND AND PURPOSE: Limited evidence was available on the metabolic syndrome and risk of cardiovascular disease in Asia. The purpose of this study is to examine the association of the metabolic syndrome and risk of ischemic cardiovascular disease in Japanese men and women. METHODS: We conducted an 18-year prospective study of 9087 Japanese people aged 40 to 69 years (3595 men and 5492 women), initially free of ischemic heart disease or stroke. During follow-up, there were 116 (74 men and 42 women) cases of ischemic heart disease and 256 (144 men and 112 women) ischemic strokes. Metabolic syndrome was defined by the modified criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATPIII), with the presence of >/=3 of the following factors: (1) serum triglycerides >/=1.69 mmol/L (150 mg/dL); (2) HDL-cholesterol <1.03 mmol/L (40 mg/dL) for men and <1.29 mmol/L (50 mg/dL) for women; (3) glucose >/=6.11 mmol/L (110 mg/dL) fasting or >/=7.77 mmol/L (140 mg/dL) nonfasting, or on treatment; (4) blood pressure > or =130/85 mm Hg or medication use, and (5) body mass index >/=25.0 kg/m(2). RESULTS: For both sexes, high blood pressure, high triglycerides and low HDL cholesterol were associated with increased risks of ischemic heart disease or stroke after adjustment for cardiovascular risk factors. A dose-response relationship was found between the number of metabolic risk factors and incidence of these cardiovascular end points. The multivariable hazard ratio (95% CI) associated with metabolic syndrome was 2.4 (1.4 to 4.0) in men and 2.3 (1.2 to 4.3) in women for ischemic heart disease, and 2.0 (1.3 to 3.1) and 1.5 (1.0 to 2.3), respectively, for ischemic stroke. The contribution of metabolic syndrome to the risks was independent of serum total cholesterol levels but stronger among smokers. CONCLUSIONS: The metabolic syndrome is a major determinant of ischemic cardiovascular disease among middle-aged Japanese men and women, in particular among smokers. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/17431205/Metabolic_syndrome_and_the_risk_of_ischemic_heart_disease_and_stroke_among_Japanese_men_and_women_ L2 - http://www.ahajournals.org/doi/full/10.1161/STROKEAHA.106.469072?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -