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Dietary animal-derived iron and fat intake and breast cancer risk in the Shanghai Breast Cancer Study.

Abstract

BACKGROUND

Dietary fats and other constituents have been studied extensively in relation to breast cancer risk. Iron, an essential micronutrient with pro-oxidant properties, has received little attention, and specific fats may augment its toxicity. We investigated the effects of iron and fats from various food sources on the risk of breast cancer.

METHODS

Participants in a population-based case-control study, 3,452 breast cancer cases, and 3,474 age-frequency-matched controls, completed in-person interviews, including a detailed food-frequency questionnaire. Plant- and animal-derived iron and fat intakes were derived from dietary intake data and food composition tables. Unconditional logistic regression models were used to study the independent and interactive effects of different forms of iron and fats on breast cancer risk.

RESULTS

Animal-derived (largely heme) iron intake was positively associated with breast cancer risk (P (trend) < 0.01; OR = 1.49 in the highest vs. lowest quartile, 95% confidence interval [CI] 1.25-1.78) after adjustment for known risk factors, antioxidant vitamin and isoflavone intake, and vitamin supplement use. The effect of animal-derived iron was similar in pre- and postmenopausal women. Intake of animal-derived fats was also associated with increased risk (adjusted OR = 1.34, 95% CI 1.14-1.58), particularly after menopause. A significant interaction between iron and fat from animal sources was observed (P < 0.01).

CONCLUSIONS

A high intake of animal-derived (heme) iron may be associated with an increased risk of primary breast cancer in Chinese women, and saturated and mono-unsaturated fats that are also derived from animal sources may augment this effect. Combined reductions in animal-derived iron and fat consumption have the potential to reduce breast cancer risk.

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  • Authors+Show Affiliations

    ,

    Division of General Internal Medicine and Public Health, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37212, USA. asha.kallianpur@vanderbilt.edu

    , , , , , , , ,

    Source

    Breast cancer research and treatment 107:1 2008 Jan pg 123-32

    MeSH

    Adult
    Aged
    Breast Neoplasms
    Case-Control Studies
    China
    Diet
    Dietary Fats
    Female
    Heme
    Humans
    Iron, Dietary
    Middle Aged
    Oxidants
    Risk
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17431764

    Citation

    Kallianpur, Asha R., et al. "Dietary Animal-derived Iron and Fat Intake and Breast Cancer Risk in the Shanghai Breast Cancer Study." Breast Cancer Research and Treatment, vol. 107, no. 1, 2008, pp. 123-32.
    Kallianpur AR, Lee SA, Gao YT, et al. Dietary animal-derived iron and fat intake and breast cancer risk in the Shanghai Breast Cancer Study. Breast Cancer Res Treat. 2008;107(1):123-32.
    Kallianpur, A. R., Lee, S. A., Gao, Y. T., Lu, W., Zheng, Y., Ruan, Z. X., ... Zheng, W. (2008). Dietary animal-derived iron and fat intake and breast cancer risk in the Shanghai Breast Cancer Study. Breast Cancer Research and Treatment, 107(1), pp. 123-32.
    Kallianpur AR, et al. Dietary Animal-derived Iron and Fat Intake and Breast Cancer Risk in the Shanghai Breast Cancer Study. Breast Cancer Res Treat. 2008;107(1):123-32. PubMed PMID: 17431764.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary animal-derived iron and fat intake and breast cancer risk in the Shanghai Breast Cancer Study. AU - Kallianpur,Asha R, AU - Lee,Sang-Ah, AU - Gao,Yu-Tang, AU - Lu,Wei, AU - Zheng,Ying, AU - Ruan,Zhi-Xian, AU - Dai,Qi, AU - Gu,Kai, AU - Shu,Xiao-Ou, AU - Zheng,Wei, Y1 - 2007/03/13/ PY - 2007/01/29/received PY - 2007/01/30/accepted PY - 2007/4/14/pubmed PY - 2009/2/4/medline PY - 2007/4/14/entrez SP - 123 EP - 32 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 107 IS - 1 N2 - BACKGROUND: Dietary fats and other constituents have been studied extensively in relation to breast cancer risk. Iron, an essential micronutrient with pro-oxidant properties, has received little attention, and specific fats may augment its toxicity. We investigated the effects of iron and fats from various food sources on the risk of breast cancer. METHODS: Participants in a population-based case-control study, 3,452 breast cancer cases, and 3,474 age-frequency-matched controls, completed in-person interviews, including a detailed food-frequency questionnaire. Plant- and animal-derived iron and fat intakes were derived from dietary intake data and food composition tables. Unconditional logistic regression models were used to study the independent and interactive effects of different forms of iron and fats on breast cancer risk. RESULTS: Animal-derived (largely heme) iron intake was positively associated with breast cancer risk (P (trend) < 0.01; OR = 1.49 in the highest vs. lowest quartile, 95% confidence interval [CI] 1.25-1.78) after adjustment for known risk factors, antioxidant vitamin and isoflavone intake, and vitamin supplement use. The effect of animal-derived iron was similar in pre- and postmenopausal women. Intake of animal-derived fats was also associated with increased risk (adjusted OR = 1.34, 95% CI 1.14-1.58), particularly after menopause. A significant interaction between iron and fat from animal sources was observed (P < 0.01). CONCLUSIONS: A high intake of animal-derived (heme) iron may be associated with an increased risk of primary breast cancer in Chinese women, and saturated and mono-unsaturated fats that are also derived from animal sources may augment this effect. Combined reductions in animal-derived iron and fat consumption have the potential to reduce breast cancer risk. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/17431764/Dietary_animal_derived_iron_and_fat_intake_and_breast_cancer_risk_in_the_Shanghai_Breast_Cancer_Study_ L2 - https://doi.org/10.1007/s10549-007-9538-3 DB - PRIME DP - Unbound Medicine ER -