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[Dopamine-dependent character of depressive-like behavior in WAG/Rij rats with genetic absence epilepsy].
Zh Vyssh Nerv Deiat Im I P Pavlova. 2007 Jan-Feb; 57(1):91-102.ZV

Abstract

Placebo-treated WAG/Rij rats (as compared to normal Wistar rats without seizure pathology) exhibited depressive-like behavior similar to that of intact rats of the same strain: decreased exploratory activity in the open field test, increased immobility in the forced swimming test, decreased sucrose consumption and preference (anhedonia). Chronic injection of tricyclic antidepressant imipramine (15 mg/kg. i.p., for 15 days) exerted a therapeutic (antidepressant) effect on depressive-like behavior in WAG/Rij rats. After cessation of antidepressant therapy, the behavior of WAG/Rij rats didn't significantly differ from that of Wistar rats. Acute (single) injection of selective D2/D3 dopamine receptor antagonist raclopride (100 microg/kg, i.p., 15 min prior to behavioral testing) aggravated the symptoms of depressive-like behavior and suppressed antidepressant effect of chronic injection of imipramine in WAG/Rij rats, whereas it didn't exert a substantial effect on behavior of Wistar rats. Injection of D2/D3 dopamine receptor agonist Parlodel (bromocriptine) counteracted the depressive-like behavior in WAG/Rij rats and didn't exert substantial influence on behavior of Wistar rats with the exception of a decrease in immobility time in the forced swimming test. Injections of imipramine and raclopride didn't exert significant influences on the level of general locomotor activity and anxiety both in WAG/Rij and Wistar rats. The results demonstrate the dopamine-dependent character of depressive-like behavior in WAG/Rij rats, and indicate possible involvement of dopamine D2-like receptors in mediation of the antidepressant effect of imipramine on genetically determined depressive-like behavior in WAG/Rij rats.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

17432322

Citation

Sarkisova, K Iu, et al. "[Dopamine-dependent Character of Depressive-like Behavior in WAG/Rij Rats With Genetic Absence Epilepsy]." Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova, vol. 57, no. 1, 2007, pp. 91-102.
Sarkisova KIu, Kulikov MA, Midzianovskaia IS, et al. [Dopamine-dependent character of depressive-like behavior in WAG/Rij rats with genetic absence epilepsy]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2007;57(1):91-102.
Sarkisova, K. I. u., Kulikov, M. A., Midzianovskaia, I. S., & Folomkina, A. A. (2007). [Dopamine-dependent character of depressive-like behavior in WAG/Rij rats with genetic absence epilepsy]. Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova, 57(1), 91-102.
Sarkisova KIu, et al. [Dopamine-dependent Character of Depressive-like Behavior in WAG/Rij Rats With Genetic Absence Epilepsy]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2007 Jan-Feb;57(1):91-102. PubMed PMID: 17432322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Dopamine-dependent character of depressive-like behavior in WAG/Rij rats with genetic absence epilepsy]. AU - Sarkisova,K Iu, AU - Kulikov,M A, AU - Midzianovskaia,I S, AU - Folomkina,A A, PY - 2007/4/17/pubmed PY - 2007/5/31/medline PY - 2007/4/17/entrez SP - 91 EP - 102 JF - Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova JO - Zh Vyssh Nerv Deiat Im I P Pavlova VL - 57 IS - 1 N2 - Placebo-treated WAG/Rij rats (as compared to normal Wistar rats without seizure pathology) exhibited depressive-like behavior similar to that of intact rats of the same strain: decreased exploratory activity in the open field test, increased immobility in the forced swimming test, decreased sucrose consumption and preference (anhedonia). Chronic injection of tricyclic antidepressant imipramine (15 mg/kg. i.p., for 15 days) exerted a therapeutic (antidepressant) effect on depressive-like behavior in WAG/Rij rats. After cessation of antidepressant therapy, the behavior of WAG/Rij rats didn't significantly differ from that of Wistar rats. Acute (single) injection of selective D2/D3 dopamine receptor antagonist raclopride (100 microg/kg, i.p., 15 min prior to behavioral testing) aggravated the symptoms of depressive-like behavior and suppressed antidepressant effect of chronic injection of imipramine in WAG/Rij rats, whereas it didn't exert a substantial effect on behavior of Wistar rats. Injection of D2/D3 dopamine receptor agonist Parlodel (bromocriptine) counteracted the depressive-like behavior in WAG/Rij rats and didn't exert substantial influence on behavior of Wistar rats with the exception of a decrease in immobility time in the forced swimming test. Injections of imipramine and raclopride didn't exert significant influences on the level of general locomotor activity and anxiety both in WAG/Rij and Wistar rats. The results demonstrate the dopamine-dependent character of depressive-like behavior in WAG/Rij rats, and indicate possible involvement of dopamine D2-like receptors in mediation of the antidepressant effect of imipramine on genetically determined depressive-like behavior in WAG/Rij rats. SN - 0044-4677 UR - https://www.unboundmedicine.com/medline/citation/17432322/[Dopamine_dependent_character_of_depressive_like_behavior_in_WAG/Rij_rats_with_genetic_absence_epilepsy]_ L2 - https://medlineplus.gov/depression.html DB - PRIME DP - Unbound Medicine ER -