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Glycated albumin is low in obese, type 2 diabetic patients.
Diabetes Res Clin Pract. 2007 Oct; 78(1):51-5.DR

Abstract

This study is to clarify whether obesity status affects glycated albumin (GA) and HbA1c levels in adults with type 2 diabetes. One hundred and seven individuals with type 2 diabetes without advanced complications participated in this study. The relationship between HbA1c, GA, hemoglobin (Hb), albumin (ALB), absolute value of GA (aGA) and Body Mass Index (BMI) were examined using Pearson's correlation coefficient. The comparison of each parameter was conducted using unpaired t-test between the obese (BMI> or =25) and the non-obese (BMI<25) group. Additionally the multiple regression analyses to find factors related with GA (i.e. BMI, HbA1c, age, ALB and the insulin therapy) were performed. HbA1c level and BMI showed very weak correlation (r=-0.04; p=0.65). However, GA, aGA and BMI showed a significant negative correlation (r=-0.28; p=0.004, r=-0.22; p=0.024). The GA and aGA values of the obese group were significant lower than those in the non-obese group. In multiple regression analysis, BMI (beta=-0.24; p=0.001) was negatively, and HbA1c (beta=3.65; p<0.001) was positively correlated with GA. In conclusion, the current analysis demonstrated a need of careful evaluation of GA values in obese diabetic patients in daily practice. Further researches are required to elucidate the underlying mechanisms.

Authors+Show Affiliations

Division of Diabetes Metabolism & Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. yumi-m@jikei.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17434227

Citation

Miyashita, Yumi, et al. "Glycated Albumin Is Low in Obese, Type 2 Diabetic Patients." Diabetes Research and Clinical Practice, vol. 78, no. 1, 2007, pp. 51-5.
Miyashita Y, Nishimura R, Morimoto A, et al. Glycated albumin is low in obese, type 2 diabetic patients. Diabetes Res Clin Pract. 2007;78(1):51-5.
Miyashita, Y., Nishimura, R., Morimoto, A., Matsudaira, T., Sano, H., & Tajima, N. (2007). Glycated albumin is low in obese, type 2 diabetic patients. Diabetes Research and Clinical Practice, 78(1), 51-5.
Miyashita Y, et al. Glycated Albumin Is Low in Obese, Type 2 Diabetic Patients. Diabetes Res Clin Pract. 2007;78(1):51-5. PubMed PMID: 17434227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycated albumin is low in obese, type 2 diabetic patients. AU - Miyashita,Yumi, AU - Nishimura,Rimei, AU - Morimoto,Aya, AU - Matsudaira,Toru, AU - Sano,Hironari, AU - Tajima,Naoko, Y1 - 2007/04/16/ PY - 2006/07/25/received PY - 2007/01/29/revised PY - 2007/02/21/accepted PY - 2007/4/17/pubmed PY - 2007/11/14/medline PY - 2007/4/17/entrez SP - 51 EP - 5 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 78 IS - 1 N2 - This study is to clarify whether obesity status affects glycated albumin (GA) and HbA1c levels in adults with type 2 diabetes. One hundred and seven individuals with type 2 diabetes without advanced complications participated in this study. The relationship between HbA1c, GA, hemoglobin (Hb), albumin (ALB), absolute value of GA (aGA) and Body Mass Index (BMI) were examined using Pearson's correlation coefficient. The comparison of each parameter was conducted using unpaired t-test between the obese (BMI> or =25) and the non-obese (BMI<25) group. Additionally the multiple regression analyses to find factors related with GA (i.e. BMI, HbA1c, age, ALB and the insulin therapy) were performed. HbA1c level and BMI showed very weak correlation (r=-0.04; p=0.65). However, GA, aGA and BMI showed a significant negative correlation (r=-0.28; p=0.004, r=-0.22; p=0.024). The GA and aGA values of the obese group were significant lower than those in the non-obese group. In multiple regression analysis, BMI (beta=-0.24; p=0.001) was negatively, and HbA1c (beta=3.65; p<0.001) was positively correlated with GA. In conclusion, the current analysis demonstrated a need of careful evaluation of GA values in obese diabetic patients in daily practice. Further researches are required to elucidate the underlying mechanisms. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/17434227/Glycated_albumin_is_low_in_obese_type_2_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(07)00151-9 DB - PRIME DP - Unbound Medicine ER -