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Hippocampal shape analysis in Alzheimer's disease: a population-based study.

Abstract

BACKGROUND

Hippocampal atrophy--particularly of the CA1 region--may be useful as a biomarker for Alzheimer's disease (AD) or the risk for AD. The extent to which the AD hippocampus can be distinguished in vivo from changes due to normal aging or other processes that affect the hippocampus is of clinical importance and is an area of active research. In this study, we use structural imaging techniques to model hippocampal size and regional shape differences between elderly men with incident AD and a non-demented comparison group of elderly men.

METHODS

Participants are Japanese-American men from the Honolulu Asia Aging Study (HAAS). The HAAS cohort has been followed since 1965. The following analysis is based on a sub-group of men who underwent MRI examination in 1994-1996. Participants were diagnosed with incident AD (n=24: age=82.5+/-4.6) or were not demented (n=102: age=83.0+/-5.9). One reader, blinded to dementia diagnosis, manually outlined the left and right hippocampal formation using published criteria. We used 3D structural shape analysis methods developed at the Laboratory of Neuro Imaging (LONI) to compare regional variation in hippocampal diameter between the AD cases and the non-demented comparison group.

RESULTS

Mean total hippocampal volume was 11.5% smaller in the AD cases than the non-demented controls (4903+/-857 mm(3) vs. 5540+/-805 mm(3)), with a similar size difference for the median left (12.0%) and median right (11.6%) hippocampus. Shape analysis showed a regional pattern of shape difference between the AD and non-demented hippocampus, more evident for the hippocampal body than the head, and the appearance of more consistent differences in the left hippocampus than the right. While assignment to a specific sub-region is not possible with this method, the surface changes primarily intersect the area of the hippocampus body containing the CA1 region (and adjacent CA2 and distal CA3), subiculum, and the dentate gyrus-hilar region.

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  • Authors+Show Affiliations

    ,

    Department of Preventive Medicine and Biometrics, Uniformed Services University, Bethesda, MD 20814, USA. ascher@usuhs.mil

    , , , , , , , , ,

    Source

    NeuroImage 36:1 2007 May 15 pg 8-18

    MeSH

    Age Factors
    Aged
    Aged, 80 and over
    Alzheimer Disease
    Atrophy
    Brain
    Cohort Studies
    Dominance, Cerebral
    Hippocampus
    Humans
    Image Enhancement
    Image Processing, Computer-Assisted
    Imaging, Three-Dimensional
    Magnetic Resonance Imaging
    Male
    Reference Values
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17434756

    Citation

    Scher, A I., et al. "Hippocampal Shape Analysis in Alzheimer's Disease: a Population-based Study." NeuroImage, vol. 36, no. 1, 2007, pp. 8-18.
    Scher AI, Xu Y, Korf ES, et al. Hippocampal shape analysis in Alzheimer's disease: a population-based study. Neuroimage. 2007;36(1):8-18.
    Scher, A. I., Xu, Y., Korf, E. S., White, L. R., Scheltens, P., Toga, A. W., ... Launer, L. J. (2007). Hippocampal shape analysis in Alzheimer's disease: a population-based study. NeuroImage, 36(1), pp. 8-18.
    Scher AI, et al. Hippocampal Shape Analysis in Alzheimer's Disease: a Population-based Study. Neuroimage. 2007 May 15;36(1):8-18. PubMed PMID: 17434756.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hippocampal shape analysis in Alzheimer's disease: a population-based study. AU - Scher,A I, AU - Xu,Y, AU - Korf,E S C, AU - White,L R, AU - Scheltens,P, AU - Toga,A W, AU - Thompson,P M, AU - Hartley,S W, AU - Witter,M P, AU - Valentino,D J, AU - Launer,L J, Y1 - 2007/03/12/ PY - 2006/07/05/received PY - 2006/11/27/revised PY - 2006/12/13/accepted PY - 2007/4/17/pubmed PY - 2007/8/2/medline PY - 2007/4/17/entrez SP - 8 EP - 18 JF - NeuroImage JO - Neuroimage VL - 36 IS - 1 N2 - BACKGROUND: Hippocampal atrophy--particularly of the CA1 region--may be useful as a biomarker for Alzheimer's disease (AD) or the risk for AD. The extent to which the AD hippocampus can be distinguished in vivo from changes due to normal aging or other processes that affect the hippocampus is of clinical importance and is an area of active research. In this study, we use structural imaging techniques to model hippocampal size and regional shape differences between elderly men with incident AD and a non-demented comparison group of elderly men. METHODS: Participants are Japanese-American men from the Honolulu Asia Aging Study (HAAS). The HAAS cohort has been followed since 1965. The following analysis is based on a sub-group of men who underwent MRI examination in 1994-1996. Participants were diagnosed with incident AD (n=24: age=82.5+/-4.6) or were not demented (n=102: age=83.0+/-5.9). One reader, blinded to dementia diagnosis, manually outlined the left and right hippocampal formation using published criteria. We used 3D structural shape analysis methods developed at the Laboratory of Neuro Imaging (LONI) to compare regional variation in hippocampal diameter between the AD cases and the non-demented comparison group. RESULTS: Mean total hippocampal volume was 11.5% smaller in the AD cases than the non-demented controls (4903+/-857 mm(3) vs. 5540+/-805 mm(3)), with a similar size difference for the median left (12.0%) and median right (11.6%) hippocampus. Shape analysis showed a regional pattern of shape difference between the AD and non-demented hippocampus, more evident for the hippocampal body than the head, and the appearance of more consistent differences in the left hippocampus than the right. While assignment to a specific sub-region is not possible with this method, the surface changes primarily intersect the area of the hippocampus body containing the CA1 region (and adjacent CA2 and distal CA3), subiculum, and the dentate gyrus-hilar region. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/17434756/Hippocampal_shape_analysis_in_Alzheimer's_disease:_a_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(06)01216-X DB - PRIME DP - Unbound Medicine ER -