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Postictal single-cell firing patterns in the hippocampus.
Epilepsia. 2007 Apr; 48(4):713-9.E

Abstract

PURPOSE

Patients with epilepsy have varying degrees of postictal impairment including confusion and amnesia. This impairment adds substantially to the disease burden of epilepsy. However, the mechanism responsible for postictal cognitive impairment is unclear. The purpose of this study was to study single-cell firing patterns in hippocampal cells after spontaneous seizures in rats previously subjected to status epilepticus.

METHODS

In this study, we monitored place cells and interneurons in the CA1 region of the hippocampus before and after spontaneous seizures in six epileptic rats with a history of status epilepticus. Place cells fire action potentials when the animal is in a specific location in space, the so-called place field. Place cell function correlates well with performance in tasks of visual-spatial memory and appears to be an excellent surrogate measure of spatial memory.

RESULTS

Twelve spontaneous seizures were recorded. After the seizures, a marked decrease in firing rate of action potentials from place cells was noted, whereas interneuron firing was unchanged. In addition, when place cell firing fields persisted or returned, they had aberrant firing fields with reduced coherence and information content. In addition to postictal suppression of firing patterns, seizures led to the emergence of firing fields in previously silent cells, demonstrating a postictal remapping of the hippocampus.

CONCLUSIONS

These findings demonstrate that postictal alterations in behavior are not due solely to reduced neuronal firing. Rather, the postictal period is characterized by robust and dynamic changes in cell-firing patterns resulting in remapping of the hippocampal map.

Authors+Show Affiliations

Neuroscience Center at Dartmouth, Section of Neurology, Dartmouth Medical School, Lebanon, New Hampshire, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17437414

Citation

Zhou, Jun-Li, et al. "Postictal Single-cell Firing Patterns in the Hippocampus." Epilepsia, vol. 48, no. 4, 2007, pp. 713-9.
Zhou JL, Lenck-Santini PP, Holmes GL. Postictal single-cell firing patterns in the hippocampus. Epilepsia. 2007;48(4):713-9.
Zhou, J. L., Lenck-Santini, P. P., & Holmes, G. L. (2007). Postictal single-cell firing patterns in the hippocampus. Epilepsia, 48(4), 713-9.
Zhou JL, Lenck-Santini PP, Holmes GL. Postictal Single-cell Firing Patterns in the Hippocampus. Epilepsia. 2007;48(4):713-9. PubMed PMID: 17437414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postictal single-cell firing patterns in the hippocampus. AU - Zhou,Jun-Li, AU - Lenck-Santini,Pierre-Pascal, AU - Holmes,Gregory L, PY - 2007/4/18/pubmed PY - 2007/7/7/medline PY - 2007/4/18/entrez SP - 713 EP - 9 JF - Epilepsia JO - Epilepsia VL - 48 IS - 4 N2 - PURPOSE: Patients with epilepsy have varying degrees of postictal impairment including confusion and amnesia. This impairment adds substantially to the disease burden of epilepsy. However, the mechanism responsible for postictal cognitive impairment is unclear. The purpose of this study was to study single-cell firing patterns in hippocampal cells after spontaneous seizures in rats previously subjected to status epilepticus. METHODS: In this study, we monitored place cells and interneurons in the CA1 region of the hippocampus before and after spontaneous seizures in six epileptic rats with a history of status epilepticus. Place cells fire action potentials when the animal is in a specific location in space, the so-called place field. Place cell function correlates well with performance in tasks of visual-spatial memory and appears to be an excellent surrogate measure of spatial memory. RESULTS: Twelve spontaneous seizures were recorded. After the seizures, a marked decrease in firing rate of action potentials from place cells was noted, whereas interneuron firing was unchanged. In addition, when place cell firing fields persisted or returned, they had aberrant firing fields with reduced coherence and information content. In addition to postictal suppression of firing patterns, seizures led to the emergence of firing fields in previously silent cells, demonstrating a postictal remapping of the hippocampus. CONCLUSIONS: These findings demonstrate that postictal alterations in behavior are not due solely to reduced neuronal firing. Rather, the postictal period is characterized by robust and dynamic changes in cell-firing patterns resulting in remapping of the hippocampal map. SN - 0013-9580 UR - https://www.unboundmedicine.com/medline/citation/17437414/Postictal_single_cell_firing_patterns_in_the_hippocampus_ L2 - https://doi.org/10.1111/j.1528-1167.2006.00942.x DB - PRIME DP - Unbound Medicine ER -