Tags

Type your tag names separated by a space and hit enter

Risk of prostate cancer for young men with a prostate specific antigen less than their age specific median.
J Urol. 2007 May; 177(5):1745-8.JU

Abstract

PURPOSE

We previously reported that the median prostate specific antigen for men 40 to 49 years old is 0.7 ng/ml and that a baseline prostate specific antigen between 0.7 and 2.5 ng/ml is associated with a 14.6-fold increased risk of prostate cancer. Although this suggests the need for close followup of men in their 40s with a prostate specific antigen level greater than 0.7 ng/ml, the appropriate screening strategy for men with a level less than the age specific median is unclear.

MATERIALS AND METHODS

From a large prostate cancer screening study 581 participants 40 to 49 years old with a baseline prostate specific antigen level less than 0.7 ng/ml were identified. All men were classified as high risk due to a positive family history and/or black heritage. Changes in prostate specific antigen over time, the cancer detection rate and pathological tumor features were examined as a function of the baseline prostate specific antigen.

RESULTS

At a median followup of 13 months 2 patients with an initial prostate specific antigen level less than 0.7 ng/ml reached the threshold for biopsy, and a single patient was diagnosed with prostate cancer. A significantly greater proportion of men with a baseline prostate specific antigen level greater than the age specific median had a prostate specific antigen velocity greater than 0.75 ng/ml per year (9% vs 3%, p=0.009) and were diagnosed with prostate cancer before age 50 (4.6% vs 0.16%, p<0.0001).

CONCLUSIONS

Men 40 to 49 years old with a prostate specific antigen less than the age specific median have a low risk of prostate cancer in the short term. Performing a baseline prostate specific antigen measurement in the fifth decade led to few additional biopsies, and was extremely useful for risk stratification since men with levels greater or less than the age specific median had strikingly different risk profiles.

Authors+Show Affiliations

Department of Urology, Georgetown University School of Medicine, Washington, DC, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17437803

Citation

Loeb, Stacy, et al. "Risk of Prostate Cancer for Young Men With a Prostate Specific Antigen Less Than Their Age Specific Median." The Journal of Urology, vol. 177, no. 5, 2007, pp. 1745-8.
Loeb S, Nadler RB, Roehl KA, et al. Risk of prostate cancer for young men with a prostate specific antigen less than their age specific median. J Urol. 2007;177(5):1745-8.
Loeb, S., Nadler, R. B., Roehl, K. A., Antenor, J. A., & Catalona, W. J. (2007). Risk of prostate cancer for young men with a prostate specific antigen less than their age specific median. The Journal of Urology, 177(5), 1745-8.
Loeb S, et al. Risk of Prostate Cancer for Young Men With a Prostate Specific Antigen Less Than Their Age Specific Median. J Urol. 2007;177(5):1745-8. PubMed PMID: 17437803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of prostate cancer for young men with a prostate specific antigen less than their age specific median. AU - Loeb,Stacy, AU - Nadler,Robert B, AU - Roehl,Kimberly A, AU - Antenor,Jo Ann V, AU - Catalona,William J, PY - 2006/08/28/received PY - 2007/4/18/pubmed PY - 2007/5/16/medline PY - 2007/4/18/entrez SP - 1745 EP - 8 JF - The Journal of urology JO - J. Urol. VL - 177 IS - 5 N2 - PURPOSE: We previously reported that the median prostate specific antigen for men 40 to 49 years old is 0.7 ng/ml and that a baseline prostate specific antigen between 0.7 and 2.5 ng/ml is associated with a 14.6-fold increased risk of prostate cancer. Although this suggests the need for close followup of men in their 40s with a prostate specific antigen level greater than 0.7 ng/ml, the appropriate screening strategy for men with a level less than the age specific median is unclear. MATERIALS AND METHODS: From a large prostate cancer screening study 581 participants 40 to 49 years old with a baseline prostate specific antigen level less than 0.7 ng/ml were identified. All men were classified as high risk due to a positive family history and/or black heritage. Changes in prostate specific antigen over time, the cancer detection rate and pathological tumor features were examined as a function of the baseline prostate specific antigen. RESULTS: At a median followup of 13 months 2 patients with an initial prostate specific antigen level less than 0.7 ng/ml reached the threshold for biopsy, and a single patient was diagnosed with prostate cancer. A significantly greater proportion of men with a baseline prostate specific antigen level greater than the age specific median had a prostate specific antigen velocity greater than 0.75 ng/ml per year (9% vs 3%, p=0.009) and were diagnosed with prostate cancer before age 50 (4.6% vs 0.16%, p<0.0001). CONCLUSIONS: Men 40 to 49 years old with a prostate specific antigen less than the age specific median have a low risk of prostate cancer in the short term. Performing a baseline prostate specific antigen measurement in the fifth decade led to few additional biopsies, and was extremely useful for risk stratification since men with levels greater or less than the age specific median had strikingly different risk profiles. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/17437803/Risk_of_prostate_cancer_for_young_men_with_a_prostate_specific_antigen_less_than_their_age_specific_median_ L2 - https://www.jurology.com/doi/full/10.1016/j.juro.2007.01.068?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -