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Relief of idiopathic subjective tinnitus: is gabapentin effective?
Arch Otolaryngol Head Neck Surg. 2007 Apr; 133(4):390-7.AO

Abstract

OBJECTIVE

To assess the therapeutic benefit of gabapentin (Neurontin) for subjective idiopathic troublesome tinnitus.

DESIGN

An 8-week, double-blind, randomized clinical trial.

SETTING

Academic otolaryngology clinic in St Louis, Mo.

SUBJECTS

One hundred thirty-five subjects with severe idiopathic subjective tinnitus of 6 months' duration or longer.

INTERVENTION

Gabapentin, at a maintenance dosage of 900 to 3600 mg/d for 8 weeks, or lactose placebo.

MAIN OUTCOME MEASURE

Change in the Tinnitus Handicap Inventory score from baseline to the study end point.

RESULTS

The overall change in the Tinnitus Handicap Inventory score for the entire cohort from baseline to week 8 was 11.2; the change among the 59 subjects randomized to the gabapentin arm was 11.3 and the change among the 56 subjects in the placebo arm was 11.0. The difference was 0.03 (95% confidence interval, -5.5 to 6.2; P = .91).

CONCLUSION

Gabapentin is no more effective than placebo for the relief of idiopathic subjective tinnitus.

TRIAL REGISTRATION

clinicaltrials.gov Identifier: NCT00317850.

Authors+Show Affiliations

Division of Clinical Outcomes Research, Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110, USA. piccirilloj@ent.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17438255

Citation

Piccirillo, Jay F., et al. "Relief of Idiopathic Subjective Tinnitus: Is Gabapentin Effective?" Archives of Otolaryngology--head & Neck Surgery, vol. 133, no. 4, 2007, pp. 390-7.
Piccirillo JF, Finnell J, Vlahiotis A, et al. Relief of idiopathic subjective tinnitus: is gabapentin effective? Arch Otolaryngol Head Neck Surg. 2007;133(4):390-7.
Piccirillo, J. F., Finnell, J., Vlahiotis, A., Chole, R. A., & Spitznagel, E. (2007). Relief of idiopathic subjective tinnitus: is gabapentin effective? Archives of Otolaryngology--head & Neck Surgery, 133(4), 390-7.
Piccirillo JF, et al. Relief of Idiopathic Subjective Tinnitus: Is Gabapentin Effective. Arch Otolaryngol Head Neck Surg. 2007;133(4):390-7. PubMed PMID: 17438255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relief of idiopathic subjective tinnitus: is gabapentin effective? AU - Piccirillo,Jay F, AU - Finnell,Joshua, AU - Vlahiotis,Anna, AU - Chole,Richard A, AU - Spitznagel,Edward,Jr PY - 2007/4/18/pubmed PY - 2007/5/16/medline PY - 2007/4/18/entrez SP - 390 EP - 7 JF - Archives of otolaryngology--head & neck surgery JO - Arch. Otolaryngol. Head Neck Surg. VL - 133 IS - 4 N2 - OBJECTIVE: To assess the therapeutic benefit of gabapentin (Neurontin) for subjective idiopathic troublesome tinnitus. DESIGN: An 8-week, double-blind, randomized clinical trial. SETTING: Academic otolaryngology clinic in St Louis, Mo. SUBJECTS: One hundred thirty-five subjects with severe idiopathic subjective tinnitus of 6 months' duration or longer. INTERVENTION: Gabapentin, at a maintenance dosage of 900 to 3600 mg/d for 8 weeks, or lactose placebo. MAIN OUTCOME MEASURE: Change in the Tinnitus Handicap Inventory score from baseline to the study end point. RESULTS: The overall change in the Tinnitus Handicap Inventory score for the entire cohort from baseline to week 8 was 11.2; the change among the 59 subjects randomized to the gabapentin arm was 11.3 and the change among the 56 subjects in the placebo arm was 11.0. The difference was 0.03 (95% confidence interval, -5.5 to 6.2; P = .91). CONCLUSION: Gabapentin is no more effective than placebo for the relief of idiopathic subjective tinnitus. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00317850. SN - 0886-4470 UR - https://www.unboundmedicine.com/medline/citation/17438255/Relief_of_idiopathic_subjective_tinnitus:_is_gabapentin_effective L2 - https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/archotol.133.4.390 DB - PRIME DP - Unbound Medicine ER -