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Protective effects of vitamins C and E against endometrial damage and oxidative stress in fluoride intoxication.
Clin Exp Pharmacol Physiol. 2007 May-Jun; 34(5-6):467-74.CE

Abstract

1. Fluoride (F) is an essential trace element that has protective effects against bone mineral loss. However, it becomes toxic at higher doses and induces some adverse effects on a number of physiological functions, including reproduction. The aims of this study were to examine F-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of vitamins C and E against possible F-induced endometrial impairment in rats. 2. Rats were divided into three groups: control, F and F plus vitamins. The F group was given 100 mg/L orally for 60 days. Combined vitamins were also administered orally. Fluoride administration to control rats significantly increased endometrial malondialdehyde (MDA) but decreased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. Endometrial glandular and stromal apoptosis were investigated by DNA nick end-labelling (TUNEL) method on each sample and the mean endometrial apoptotic index (AI) was calculated. 3. Vitamin administration with F treatment caused endometrial MDA to decrease, but SOD, GSH-Px and CAT activities to increase, all to significant levels. Vitamins showed a histopathological protection against F-induced endometrial damage. There was a significant difference in the AI between the groups. Lymphocyte and eosinophil infiltration in stroma in F-treated rats were more than those in the control and F + Vit groups. 4. It can be concluded that oxidative endometrial damage plays an important role in F-induced endometrial toxicity, and the modulation of oxidative stress with vitamins reduces F-induced endometrial damage both at the biochemical and histological levels.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. mguney@med.sdu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17439417

Citation

Guney, Mehmet, et al. "Protective Effects of Vitamins C and E Against Endometrial Damage and Oxidative Stress in Fluoride Intoxication." Clinical and Experimental Pharmacology & Physiology, vol. 34, no. 5-6, 2007, pp. 467-74.
Guney M, Oral B, Demirin H, et al. Protective effects of vitamins C and E against endometrial damage and oxidative stress in fluoride intoxication. Clin Exp Pharmacol Physiol. 2007;34(5-6):467-74.
Guney, M., Oral, B., Demirin, H., Karahan, N., Mungan, T., & Delibas, N. (2007). Protective effects of vitamins C and E against endometrial damage and oxidative stress in fluoride intoxication. Clinical and Experimental Pharmacology & Physiology, 34(5-6), 467-74.
Guney M, et al. Protective Effects of Vitamins C and E Against Endometrial Damage and Oxidative Stress in Fluoride Intoxication. Clin Exp Pharmacol Physiol. 2007 May-Jun;34(5-6):467-74. PubMed PMID: 17439417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of vitamins C and E against endometrial damage and oxidative stress in fluoride intoxication. AU - Guney,Mehmet, AU - Oral,Baha, AU - Demirin,Hilmi, AU - Karahan,Nermin, AU - Mungan,Tamer, AU - Delibas,Namik, PY - 2007/4/19/pubmed PY - 2007/8/19/medline PY - 2007/4/19/entrez SP - 467 EP - 74 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 34 IS - 5-6 N2 - 1. Fluoride (F) is an essential trace element that has protective effects against bone mineral loss. However, it becomes toxic at higher doses and induces some adverse effects on a number of physiological functions, including reproduction. The aims of this study were to examine F-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of vitamins C and E against possible F-induced endometrial impairment in rats. 2. Rats were divided into three groups: control, F and F plus vitamins. The F group was given 100 mg/L orally for 60 days. Combined vitamins were also administered orally. Fluoride administration to control rats significantly increased endometrial malondialdehyde (MDA) but decreased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. Endometrial glandular and stromal apoptosis were investigated by DNA nick end-labelling (TUNEL) method on each sample and the mean endometrial apoptotic index (AI) was calculated. 3. Vitamin administration with F treatment caused endometrial MDA to decrease, but SOD, GSH-Px and CAT activities to increase, all to significant levels. Vitamins showed a histopathological protection against F-induced endometrial damage. There was a significant difference in the AI between the groups. Lymphocyte and eosinophil infiltration in stroma in F-treated rats were more than those in the control and F + Vit groups. 4. It can be concluded that oxidative endometrial damage plays an important role in F-induced endometrial toxicity, and the modulation of oxidative stress with vitamins reduces F-induced endometrial damage both at the biochemical and histological levels. SN - 0305-1870 UR - https://www.unboundmedicine.com/medline/citation/17439417/Protective_effects_of_vitamins_C_and_E_against_endometrial_damage_and_oxidative_stress_in_fluoride_intoxication_ L2 - https://doi.org/10.1111/j.1440-1681.2007.04596.x DB - PRIME DP - Unbound Medicine ER -