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Autochthonous hepatitis E in southwest England.
J Viral Hepat. 2007 May; 14(5):304-9.JV

Abstract

Although autochthonous hepatitis E has been reported in developed countries, its extent and nature in the United Kingdom are unclear. The aim of the present study was to report the natural history, lifestyle risk factors and molecular epidemiology of autochthonous hepatitis E infection in southwest England. Three hundred and thirty-three patients with unexplained hepatitis were tested for markers of hepatitis E virus (HEV) infection over a 7-year period. HEV RNA isolated from the cases was amplified and characterized. Of the 333 patients, 21 had autochthonous hepatitis E. Patients were middle-aged or elderly and males were more commonly affected. Clinical manifestations ranged from asymptomatic infection to severe hepatitis. Of the 21 patients, 20 recovered within 6 weeks. None of the cases had travelled to an area endemic for HEV. None of the patients were vegetarian and all ate pork. Of the 21 cases, 20 occurred in the spring, summer and autumn months. All polymerase-chain-reaction-confirmed cases carried HEV genotype 3, which bore close sequence homology to HEV circulating in UK pigs. In the United Kingdom, autochthonous hepatitis E may be more common than previously recognized. Although the mode of transmission remains to be determined, it may be a zoonosis with pigs as a reservoir. Hepatitis E should be considered a public health issue in the United Kingdom.

Authors+Show Affiliations

Cornwall Gastrointestinal Unit, Royal Cornwall Hospital Trust, Truro, UK. harry.dalton@rcht.cornwall.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17439519

Citation

Dalton, H R., et al. "Autochthonous Hepatitis E in Southwest England." Journal of Viral Hepatitis, vol. 14, no. 5, 2007, pp. 304-9.
Dalton HR, Thurairajah PH, Fellows HJ, et al. Autochthonous hepatitis E in southwest England. J Viral Hepat. 2007;14(5):304-9.
Dalton, H. R., Thurairajah, P. H., Fellows, H. J., Hussaini, H. S., Mitchell, J., Bendall, R., Banks, M., Ijaz, S., Teo, C. G., & Levine, D. F. (2007). Autochthonous hepatitis E in southwest England. Journal of Viral Hepatitis, 14(5), 304-9.
Dalton HR, et al. Autochthonous Hepatitis E in Southwest England. J Viral Hepat. 2007;14(5):304-9. PubMed PMID: 17439519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autochthonous hepatitis E in southwest England. AU - Dalton,H R, AU - Thurairajah,P H, AU - Fellows,H J, AU - Hussaini,H S, AU - Mitchell,J, AU - Bendall,R, AU - Banks,M, AU - Ijaz,S, AU - Teo,C-G, AU - Levine,D F, PY - 2007/4/19/pubmed PY - 2007/6/15/medline PY - 2007/4/19/entrez SP - 304 EP - 9 JF - Journal of viral hepatitis JO - J Viral Hepat VL - 14 IS - 5 N2 - Although autochthonous hepatitis E has been reported in developed countries, its extent and nature in the United Kingdom are unclear. The aim of the present study was to report the natural history, lifestyle risk factors and molecular epidemiology of autochthonous hepatitis E infection in southwest England. Three hundred and thirty-three patients with unexplained hepatitis were tested for markers of hepatitis E virus (HEV) infection over a 7-year period. HEV RNA isolated from the cases was amplified and characterized. Of the 333 patients, 21 had autochthonous hepatitis E. Patients were middle-aged or elderly and males were more commonly affected. Clinical manifestations ranged from asymptomatic infection to severe hepatitis. Of the 21 patients, 20 recovered within 6 weeks. None of the cases had travelled to an area endemic for HEV. None of the patients were vegetarian and all ate pork. Of the 21 cases, 20 occurred in the spring, summer and autumn months. All polymerase-chain-reaction-confirmed cases carried HEV genotype 3, which bore close sequence homology to HEV circulating in UK pigs. In the United Kingdom, autochthonous hepatitis E may be more common than previously recognized. Although the mode of transmission remains to be determined, it may be a zoonosis with pigs as a reservoir. Hepatitis E should be considered a public health issue in the United Kingdom. SN - 1352-0504 UR - https://www.unboundmedicine.com/medline/citation/17439519/Autochthonous_hepatitis_E_in_southwest_England_ L2 - https://doi.org/10.1111/j.1365-2893.2006.00800.x DB - PRIME DP - Unbound Medicine ER -