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Melatonin as a potential antihypertensive treatment.

Abstract

The number of patients with well-controlled hypertension is alarmingly low worldwide and new approaches to treatment of increased blood pressure (BP) are being sought. Melatonin has a role in blood pressure regulation. The nighttime production of melatonin is found to be reduced in hypertensive individuals. Administration of melatonin decreased BP in several animal models of hypertension, in healthy men and women, and in patients with arterial hypertension. Most promising results were achieved in patients with non-dipping nighttime pressure, in which the circadian rhythm of BP variation is disturbed. Several potential mechanisms of BP reduction are considered. Melatonin can, via its scavenging and antioxidant nature, improve endothelial function with increased availability of nitric oxide exerting vasodilatory and hypotensive effects. Melatonin seems to interfere with peripheral and central autonomic system, with a subsequent decrease in the tone of the adrenergic system and an increase of the cholinergic system. Melatonin may act on BP also via specific melatonin receptors localized in peripheral vessels or in parts of central nervous system participating in BP control. With a large clinical trial using melatonin in hypertension treatment, many important questions could be answered, such as the dose of melatonin and regimen of its application, the choice of patients with greatest possible benefit from melatonin treatment, the potential of anti-remodeling effect of melatonin and the interaction of melatonin with other antihypertensive drugs.

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  • Authors+Show Affiliations

    ,

    Department of Pathophysiology, School of Medicine, Komensdy University, Bratislava, Slovak Republic. fedor.simko@fmed.uniba.sk

    Source

    Journal of pineal research 42:4 2007 Apr pg 319-22

    MeSH

    Animals
    Antihypertensive Agents
    Blood Pressure
    Circadian Rhythm
    Disease Models, Animal
    Female
    Humans
    Hypertension
    Male
    Melatonin
    Receptors, Melatonin

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    17439547

    Citation

    Simko, Fedor, and Ludovit Paulis. "Melatonin as a Potential Antihypertensive Treatment." Journal of Pineal Research, vol. 42, no. 4, 2007, pp. 319-22.
    Simko F, Paulis L. Melatonin as a potential antihypertensive treatment. J Pineal Res. 2007;42(4):319-22.
    Simko, F., & Paulis, L. (2007). Melatonin as a potential antihypertensive treatment. Journal of Pineal Research, 42(4), pp. 319-22.
    Simko F, Paulis L. Melatonin as a Potential Antihypertensive Treatment. J Pineal Res. 2007;42(4):319-22. PubMed PMID: 17439547.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Melatonin as a potential antihypertensive treatment. AU - Simko,Fedor, AU - Paulis,Ludovit, PY - 2007/4/19/pubmed PY - 2007/5/23/medline PY - 2007/4/19/entrez SP - 319 EP - 22 JF - Journal of pineal research JO - J. Pineal Res. VL - 42 IS - 4 N2 - The number of patients with well-controlled hypertension is alarmingly low worldwide and new approaches to treatment of increased blood pressure (BP) are being sought. Melatonin has a role in blood pressure regulation. The nighttime production of melatonin is found to be reduced in hypertensive individuals. Administration of melatonin decreased BP in several animal models of hypertension, in healthy men and women, and in patients with arterial hypertension. Most promising results were achieved in patients with non-dipping nighttime pressure, in which the circadian rhythm of BP variation is disturbed. Several potential mechanisms of BP reduction are considered. Melatonin can, via its scavenging and antioxidant nature, improve endothelial function with increased availability of nitric oxide exerting vasodilatory and hypotensive effects. Melatonin seems to interfere with peripheral and central autonomic system, with a subsequent decrease in the tone of the adrenergic system and an increase of the cholinergic system. Melatonin may act on BP also via specific melatonin receptors localized in peripheral vessels or in parts of central nervous system participating in BP control. With a large clinical trial using melatonin in hypertension treatment, many important questions could be answered, such as the dose of melatonin and regimen of its application, the choice of patients with greatest possible benefit from melatonin treatment, the potential of anti-remodeling effect of melatonin and the interaction of melatonin with other antihypertensive drugs. SN - 0742-3098 UR - https://www.unboundmedicine.com/medline/citation/17439547/Melatonin_as_a_potential_antihypertensive_treatment_ L2 - https://doi.org/10.1111/j.1600-079X.2007.00436.x DB - PRIME DP - Unbound Medicine ER -