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Normal variation in intraepithelial lymphocytes of the terminal ileum.
Am J Clin Pathol. 2007 May; 127(5):816-9.AJ

Abstract

The number of intraepithelial lymphocytes (IELs) is often increased in the terminal ileum of patients with immune-mediated inflammatory diseases of the colon. However, data regarding their number in normal ileal mucosa of asymptomatic patients are lacking. We aimed to establish the acceptable range of IELs in biopsy specimens of normal ileal mucosa. Ileal mucosal biopsy specimens obtained during colonoscopy of 61 asymptomatic patients without endoscopic or pathologic evidence of colitis were immunostained for CD3 to assess the number of IELs present in each specimen. CD3+ lymphocytes were counted in 3 well-oriented villi and results expressed as the average for each biopsy specimen. The study group included 25 males and 36 females, ranging in age from 10 to 84 years (mean, 44.4 years). The mean +/- SD number of ileal CD3+ cells per 100 enterocytes for the group was 3.8 +/- 2 (median, 3; range, 0-9). In addition, there was a significant inverse relationship between the number of villus IELs and increasing age. Occasional IELs (approximately 4/100 villus enterocytes) are normally present in ileal biopsy specimens from asymptomatic patients without colitis. One should avoid overinterpreting the importance of occasional IELs in ileal biopsy specimens from asymptomatic patients.

Authors+Show Affiliations

Department of Pathology, University of Pittsburgh Medical Center, St Margaret's Hospital, Pittsburgh, PA, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17439842

Citation

Istvanic, Smiljana, et al. "Normal Variation in Intraepithelial Lymphocytes of the Terminal Ileum." American Journal of Clinical Pathology, vol. 127, no. 5, 2007, pp. 816-9.
Istvanic S, Yantiss RK, Baker SP, et al. Normal variation in intraepithelial lymphocytes of the terminal ileum. Am J Clin Pathol. 2007;127(5):816-9.
Istvanic, S., Yantiss, R. K., Baker, S. P., & Banner, B. F. (2007). Normal variation in intraepithelial lymphocytes of the terminal ileum. American Journal of Clinical Pathology, 127(5), 816-9.
Istvanic S, et al. Normal Variation in Intraepithelial Lymphocytes of the Terminal Ileum. Am J Clin Pathol. 2007;127(5):816-9. PubMed PMID: 17439842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Normal variation in intraepithelial lymphocytes of the terminal ileum. AU - Istvanic,Smiljana, AU - Yantiss,Rhonda K, AU - Baker,Stephen P, AU - Banner,Barbara F, PY - 2007/4/19/pubmed PY - 2007/6/1/medline PY - 2007/4/19/entrez SP - 816 EP - 9 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 127 IS - 5 N2 - The number of intraepithelial lymphocytes (IELs) is often increased in the terminal ileum of patients with immune-mediated inflammatory diseases of the colon. However, data regarding their number in normal ileal mucosa of asymptomatic patients are lacking. We aimed to establish the acceptable range of IELs in biopsy specimens of normal ileal mucosa. Ileal mucosal biopsy specimens obtained during colonoscopy of 61 asymptomatic patients without endoscopic or pathologic evidence of colitis were immunostained for CD3 to assess the number of IELs present in each specimen. CD3+ lymphocytes were counted in 3 well-oriented villi and results expressed as the average for each biopsy specimen. The study group included 25 males and 36 females, ranging in age from 10 to 84 years (mean, 44.4 years). The mean +/- SD number of ileal CD3+ cells per 100 enterocytes for the group was 3.8 +/- 2 (median, 3; range, 0-9). In addition, there was a significant inverse relationship between the number of villus IELs and increasing age. Occasional IELs (approximately 4/100 villus enterocytes) are normally present in ileal biopsy specimens from asymptomatic patients without colitis. One should avoid overinterpreting the importance of occasional IELs in ileal biopsy specimens from asymptomatic patients. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/17439842/Normal_variation_in_intraepithelial_lymphocytes_of_the_terminal_ileum_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/V1GCW4DHTHM9WVXJ DB - PRIME DP - Unbound Medicine ER -