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Primary sclerosing cholangitis.
Gastroenterol Nurs 2007 Mar-Apr; 30(2):102-5; quiz 105-7GN

Abstract

Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown origin characterized by progressive inflammation, destruction, and fibrosis of the intrahepatic and extrahepatic bile ducts. The disease leads to obliteration of intrahepatic bile ducts and to biliary cirrhosis, end-stage liver disease, and portal hypertension. Primary sclerosing cholangitis commonly occurs in the presence of inflammatory bowel disease. Its exact etiology remains unknown. As a result, there is no existing effective medical management to delay or modify the progression of the disease. Ursodeoxycholic acid, the most well-studied drug for primary sclerosing cholangitis, has demonstrated promising results when used in combination with an immunosuppressant or antibiotic. To date, liver transplantation remains the only confirmed long-term treatment of primary sclerosing cholangitis, which now accounts for 6% of adult and 1% of pediatric liver transplantations in the United States. Primary sclerosing cholangitis represents an important liver disease with major morbidity and mortality.

Authors+Show Affiliations

Orthopedic Trauma Unit, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. alexgonzales@rcn.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17440311

Citation

Geonzon-Gonzales, Mariben R.. "Primary Sclerosing Cholangitis." Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates, vol. 30, no. 2, 2007, pp. 102-5; quiz 105-7.
Geonzon-Gonzales MR. Primary sclerosing cholangitis. Gastroenterol Nurs. 2007;30(2):102-5; quiz 105-7.
Geonzon-Gonzales, M. R. (2007). Primary sclerosing cholangitis. Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates, 30(2), pp. 102-5; quiz 105-7.
Geonzon-Gonzales MR. Primary Sclerosing Cholangitis. Gastroenterol Nurs. 2007;30(2):102-5; quiz 105-7. PubMed PMID: 17440311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary sclerosing cholangitis. A1 - Geonzon-Gonzales,Mariben R, PY - 2007/4/19/pubmed PY - 2007/6/5/medline PY - 2007/4/19/entrez SP - 102-5; quiz 105-7 JF - Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates JO - Gastroenterol Nurs VL - 30 IS - 2 N2 - Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown origin characterized by progressive inflammation, destruction, and fibrosis of the intrahepatic and extrahepatic bile ducts. The disease leads to obliteration of intrahepatic bile ducts and to biliary cirrhosis, end-stage liver disease, and portal hypertension. Primary sclerosing cholangitis commonly occurs in the presence of inflammatory bowel disease. Its exact etiology remains unknown. As a result, there is no existing effective medical management to delay or modify the progression of the disease. Ursodeoxycholic acid, the most well-studied drug for primary sclerosing cholangitis, has demonstrated promising results when used in combination with an immunosuppressant or antibiotic. To date, liver transplantation remains the only confirmed long-term treatment of primary sclerosing cholangitis, which now accounts for 6% of adult and 1% of pediatric liver transplantations in the United States. Primary sclerosing cholangitis represents an important liver disease with major morbidity and mortality. SN - 1042-895X UR - https://www.unboundmedicine.com/medline/citation/17440311/Primary_sclerosing_cholangitis_ L2 - http://Insights.ovid.com/pubmed?pmid=17440311 DB - PRIME DP - Unbound Medicine ER -