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Effects of products made from a high-palmitic acid, trans-free semiliquid fat or a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile and on C-reactive protein concentrations in humans.
Eur J Clin Nutr. 2008 May; 62(5):617-24.EJ

Abstract

BACKGROUND

Many studies have shown that trans fatty acids have unfavorable effects on the serum lipoprotein profile. In general, however, fats were compared with different functional characteristics, which lower the practical applications of the results.

OBJECTIVE

The major aim of this study was to compare the effects of a high-palmitic acid, trans-free semiliquid fat with those of a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile of healthy subjects.

SUBJECTS AND DESIGN

Forty-four subjects (33 women and 11 men) consumed, in random order, two experimental diets, each for 3 weeks. Diets provided 40 energy percent (En%) from fat, while 15 En% was supplied by the experimental fats. At the end of each intervention period, concentrations of serum lipoproteins, C-reactive protein, glucose and insulin were measured.

RESULTS

When subjects consumed the high-oleic acid, low-trans semiliquid fat, intakes of stearic acid (+1.3 En%), oleic acid (+2.9 En%), alpha-linolenic acid (+0.1 En%) and trans fatty acids (+0.6 En%) were higher and that of palmitic acid (-4.2 En%) lower. Serum concentration of low-density lipoprotein cholesterol decreased by 0.34+/-0.39 mmol/l (mean+/-s.d.; 95% confidence interval (CI), -0.46 to -0.23 mmol/l; P<0.001) and high-density lipoprotein (HDL) cholesterol by -0.06+/-0.17 mmol/l (95% CI, -0.11 to -0.01 mmol/l; P=0.021). Also, the total to HDL cholesterol ratio was lower (-0.15+/-0.34; 95% CI, -0.25 to -0.05; P=0.006). Other parameters did not change.

CONCLUSIONS

A high-oleic acid, low-trans semiliquid fat has a more favorable effect on the serum lipoprotein profile than a trans-free semiliquid fat with comparable functional characteristics, but high in palmitic acid.

Authors+Show Affiliations

Department of Human Biology, Maastricht University, Maastricht, The Netherlands. R.Mensink@hb.unimaas.nl

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17440525

Citation

Mensink, R P.. "Effects of Products Made From a High-palmitic Acid, Trans-free Semiliquid Fat or a High-oleic Acid, Low-trans Semiliquid Fat On the Serum Lipoprotein Profile and On C-reactive Protein Concentrations in Humans." European Journal of Clinical Nutrition, vol. 62, no. 5, 2008, pp. 617-24.
Mensink RP. Effects of products made from a high-palmitic acid, trans-free semiliquid fat or a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile and on C-reactive protein concentrations in humans. Eur J Clin Nutr. 2008;62(5):617-24.
Mensink, R. P. (2008). Effects of products made from a high-palmitic acid, trans-free semiliquid fat or a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile and on C-reactive protein concentrations in humans. European Journal of Clinical Nutrition, 62(5), 617-24.
Mensink RP. Effects of Products Made From a High-palmitic Acid, Trans-free Semiliquid Fat or a High-oleic Acid, Low-trans Semiliquid Fat On the Serum Lipoprotein Profile and On C-reactive Protein Concentrations in Humans. Eur J Clin Nutr. 2008;62(5):617-24. PubMed PMID: 17440525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of products made from a high-palmitic acid, trans-free semiliquid fat or a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile and on C-reactive protein concentrations in humans. A1 - Mensink,R P, Y1 - 2007/04/18/ PY - 2007/4/19/pubmed PY - 2008/9/16/medline PY - 2007/4/19/entrez SP - 617 EP - 24 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 5 N2 - BACKGROUND: Many studies have shown that trans fatty acids have unfavorable effects on the serum lipoprotein profile. In general, however, fats were compared with different functional characteristics, which lower the practical applications of the results. OBJECTIVE: The major aim of this study was to compare the effects of a high-palmitic acid, trans-free semiliquid fat with those of a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile of healthy subjects. SUBJECTS AND DESIGN: Forty-four subjects (33 women and 11 men) consumed, in random order, two experimental diets, each for 3 weeks. Diets provided 40 energy percent (En%) from fat, while 15 En% was supplied by the experimental fats. At the end of each intervention period, concentrations of serum lipoproteins, C-reactive protein, glucose and insulin were measured. RESULTS: When subjects consumed the high-oleic acid, low-trans semiliquid fat, intakes of stearic acid (+1.3 En%), oleic acid (+2.9 En%), alpha-linolenic acid (+0.1 En%) and trans fatty acids (+0.6 En%) were higher and that of palmitic acid (-4.2 En%) lower. Serum concentration of low-density lipoprotein cholesterol decreased by 0.34+/-0.39 mmol/l (mean+/-s.d.; 95% confidence interval (CI), -0.46 to -0.23 mmol/l; P<0.001) and high-density lipoprotein (HDL) cholesterol by -0.06+/-0.17 mmol/l (95% CI, -0.11 to -0.01 mmol/l; P=0.021). Also, the total to HDL cholesterol ratio was lower (-0.15+/-0.34; 95% CI, -0.25 to -0.05; P=0.006). Other parameters did not change. CONCLUSIONS: A high-oleic acid, low-trans semiliquid fat has a more favorable effect on the serum lipoprotein profile than a trans-free semiliquid fat with comparable functional characteristics, but high in palmitic acid. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17440525/Effects_of_products_made_from_a_high_palmitic_acid_trans_free_semiliquid_fat_or_a_high_oleic_acid_low_trans_semiliquid_fat_on_the_serum_lipoprotein_profile_and_on_C_reactive_protein_concentrations_in_humans_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602756 DB - PRIME DP - Unbound Medicine ER -