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Effect of beta-blockers on beta3-adrenoceptor expression in chronic heart failure.
Cardiovasc Drugs Ther. 2007 Apr; 21(2):85-90.CD

Abstract

OBJECTIVES

To investigate the expression of beta(3)-adrenoceptors in rats with chronic heart failure, and to explore the effect of beta-blockers on beta(3)-adrenoceptor expression.

MATERIALS AND METHODS

Thirty-two male Wistar rats were divided into Sham (n = 10) and heart failure (n = 22) groups. The heart failure group was treated with normal saline (Heart Failure Control, n = 6), Metoprolol (n = 8) or Carvedilol (n = 8) for 3 months.

RESULTS

The left ventricular end systolic pressure (LVESP) and the absolute values of maximal rate of rise and fall of left ventricular pressure (+/-dP/dt max) in the heart failure group were lower than in the Sham group (P < 0.01), whereas the left ventricular end diastolic pressure (LVEDP) was higher (P < 0.01). The LVESP and dP/dtmax in the Carvedilol group were higher than the Metoprolol group whereas LVEDP was lower (P < 0.01). The left ventricular mass index (LVMI) in the Carvedilol group was less than the Metoprolol and Heart Failure Control groups (P < 0.01). The level of beta(3)-adrenoceptor expression in the study groups was significantly higher than the Sham group (P < 0.01). beta(3)-adrenoceptor expression in the Carvedilol group was lower than the Heart Failure Control and Metoprolol groups (P < 0.01).

CONCLUSION

beta(3)-adrenoceptor expression is increased in the failing ventricles in rats. Carvedilol is more effective than Metoprolol for improving the hemodynamics and in attenuating ventricular remodeling after heart failure. Carvedilol, rather than Metoprolol, diminishes beta(3)-adrenoceptor expression in the failing ventricles.

Authors+Show Affiliations

Department of Cardiology, The Red Cross Hospital of Guangzhou City, the Fourth Affiliated Hospital of Jinan University, Guangzhou 510220, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17440824

Citation

Zhao, Qiang, et al. "Effect of Beta-blockers On Beta3-adrenoceptor Expression in Chronic Heart Failure." Cardiovascular Drugs and Therapy, vol. 21, no. 2, 2007, pp. 85-90.
Zhao Q, Wu TG, Jiang ZF, et al. Effect of beta-blockers on beta3-adrenoceptor expression in chronic heart failure. Cardiovasc Drugs Ther. 2007;21(2):85-90.
Zhao, Q., Wu, T. G., Jiang, Z. F., Chen, G. W., Lin, Y., & Wang, L. X. (2007). Effect of beta-blockers on beta3-adrenoceptor expression in chronic heart failure. Cardiovascular Drugs and Therapy, 21(2), 85-90.
Zhao Q, et al. Effect of Beta-blockers On Beta3-adrenoceptor Expression in Chronic Heart Failure. Cardiovasc Drugs Ther. 2007;21(2):85-90. PubMed PMID: 17440824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of beta-blockers on beta3-adrenoceptor expression in chronic heart failure. AU - Zhao,Qiang, AU - Wu,Tong-Guo, AU - Jiang,Zuo-Fen, AU - Chen,Guo-Wei, AU - Lin,Yi, AU - Wang,Le-Xin, PY - 2007/4/19/pubmed PY - 2007/11/9/medline PY - 2007/4/19/entrez SP - 85 EP - 90 JF - Cardiovascular drugs and therapy JO - Cardiovasc Drugs Ther VL - 21 IS - 2 N2 - OBJECTIVES: To investigate the expression of beta(3)-adrenoceptors in rats with chronic heart failure, and to explore the effect of beta-blockers on beta(3)-adrenoceptor expression. MATERIALS AND METHODS: Thirty-two male Wistar rats were divided into Sham (n = 10) and heart failure (n = 22) groups. The heart failure group was treated with normal saline (Heart Failure Control, n = 6), Metoprolol (n = 8) or Carvedilol (n = 8) for 3 months. RESULTS: The left ventricular end systolic pressure (LVESP) and the absolute values of maximal rate of rise and fall of left ventricular pressure (+/-dP/dt max) in the heart failure group were lower than in the Sham group (P < 0.01), whereas the left ventricular end diastolic pressure (LVEDP) was higher (P < 0.01). The LVESP and dP/dtmax in the Carvedilol group were higher than the Metoprolol group whereas LVEDP was lower (P < 0.01). The left ventricular mass index (LVMI) in the Carvedilol group was less than the Metoprolol and Heart Failure Control groups (P < 0.01). The level of beta(3)-adrenoceptor expression in the study groups was significantly higher than the Sham group (P < 0.01). beta(3)-adrenoceptor expression in the Carvedilol group was lower than the Heart Failure Control and Metoprolol groups (P < 0.01). CONCLUSION: beta(3)-adrenoceptor expression is increased in the failing ventricles in rats. Carvedilol is more effective than Metoprolol for improving the hemodynamics and in attenuating ventricular remodeling after heart failure. Carvedilol, rather than Metoprolol, diminishes beta(3)-adrenoceptor expression in the failing ventricles. SN - 0920-3206 UR - https://www.unboundmedicine.com/medline/citation/17440824/Effect_of_beta_blockers_on_beta3_adrenoceptor_expression_in_chronic_heart_failure_ L2 - https://doi.org/10.1007/s10557-007-6016-4 DB - PRIME DP - Unbound Medicine ER -