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[Leptin correlates with distribution of fatty tissue and plasma levels of insulin, testosterone and tumor necrosis factor alpha in perimenopausal women with increased testosterone level and central location of body fat].
Przegl Lek. 2006; 63(8):640-4.PL

Abstract

AIM

The evaluation of the influence of testosterone and fat tissue distribution on the serum leptin levels in perimenopausal women.

PATIENTS

93 perimenopausal women without HRT (age: 51.0 +/- 8.8 yrs, FSH: 68.0 +/- 49.4 IU/l, estradiol: 38.3 +/- 37.0 ng/1) were divided into group A - 63 women with serum testosterone level < 0.6 ng/ml and group B--30 women with serum testosterone > or = 0.6 ng/ml. Each group was later divided according to WHR into subgroup I (AI and BI) (WHR < 0.8) and II (AII and BII) (WHR > or = 0.8).

METHODS

Basic fasting serum levels of LH, FSH, PRL, estradiol, insulin, hGH, IGF-I, IGFBP-1, IGFBP-3, leptin, testosterone, DHEAS TNF-alpha and SHBG were measured by RIA kits. Total cholesterol, HDL and LDL cholesterol, as well as triglycerides plasma levels were measured. Statistical evaluation was carried out by ANOVA and linear regression.

RESULTS

BMI, WHR and plasma DHEAS level were higher in group B vs. group A. The lowest hGH, HDL-cholesterol and the highest TNF-alpha levels were found in group BII. The relations leptin/BMI and leptin/body mass were found in each group. The inverse relation between leptin and IGFBP-1 was found in groups A and B. In group A the inverse relations leptin/HDL-cholesterol and leptin/ DHEAS were observed. In group B the direct leptin/testosterone and inverse leptin/IGF-I relations were found. In group AI the inverse leptin/DHEAS relation remained, while in group AII inverse leptin/HDL-cholesterol relation remained and reverse leptin/IGFBP-1 relation was significant. The direct leptin/testosterone, leptin/WHR and inverse leptin/TNF-alpha links were observed in group BII.

CONCLUSION

The serum leptin level was linked to WHR, serum testosterone, insulin, TNF-alpha levels only in groups of perimenopausal women with such cardiovascular risk factors as high WHR, overweight, high serum TNF-alpha and testosterone levels.

Authors+Show Affiliations

Klinika Endokrynologii Ginekologicznej, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie. momilewi@cyf-kr.edu.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

17441374

Citation

Milewicz, Tomasz, et al. "[Leptin Correlates With Distribution of Fatty Tissue and Plasma Levels of Insulin, Testosterone and Tumor Necrosis Factor Alpha in Perimenopausal Women With Increased Testosterone Level and Central Location of Body Fat]." Przeglad Lekarski, vol. 63, no. 8, 2006, pp. 640-4.
Milewicz T, Krzysiek J, Janczak-Saif A, et al. [Leptin correlates with distribution of fatty tissue and plasma levels of insulin, testosterone and tumor necrosis factor alpha in perimenopausal women with increased testosterone level and central location of body fat]. Przegl Lek. 2006;63(8):640-4.
Milewicz, T., Krzysiek, J., Janczak-Saif, A., & Sztefko, K. (2006). [Leptin correlates with distribution of fatty tissue and plasma levels of insulin, testosterone and tumor necrosis factor alpha in perimenopausal women with increased testosterone level and central location of body fat]. Przeglad Lekarski, 63(8), 640-4.
Milewicz T, et al. [Leptin Correlates With Distribution of Fatty Tissue and Plasma Levels of Insulin, Testosterone and Tumor Necrosis Factor Alpha in Perimenopausal Women With Increased Testosterone Level and Central Location of Body Fat]. Przegl Lek. 2006;63(8):640-4. PubMed PMID: 17441374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Leptin correlates with distribution of fatty tissue and plasma levels of insulin, testosterone and tumor necrosis factor alpha in perimenopausal women with increased testosterone level and central location of body fat]. AU - Milewicz,Tomasz, AU - Krzysiek,Józef, AU - Janczak-Saif,Agnieszka, AU - Sztefko,Krystyna, PY - 2007/4/20/pubmed PY - 2007/7/18/medline PY - 2007/4/20/entrez SP - 640 EP - 4 JF - Przeglad lekarski JO - Przegl Lek VL - 63 IS - 8 N2 - AIM: The evaluation of the influence of testosterone and fat tissue distribution on the serum leptin levels in perimenopausal women. PATIENTS: 93 perimenopausal women without HRT (age: 51.0 +/- 8.8 yrs, FSH: 68.0 +/- 49.4 IU/l, estradiol: 38.3 +/- 37.0 ng/1) were divided into group A - 63 women with serum testosterone level < 0.6 ng/ml and group B--30 women with serum testosterone > or = 0.6 ng/ml. Each group was later divided according to WHR into subgroup I (AI and BI) (WHR < 0.8) and II (AII and BII) (WHR > or = 0.8). METHODS: Basic fasting serum levels of LH, FSH, PRL, estradiol, insulin, hGH, IGF-I, IGFBP-1, IGFBP-3, leptin, testosterone, DHEAS TNF-alpha and SHBG were measured by RIA kits. Total cholesterol, HDL and LDL cholesterol, as well as triglycerides plasma levels were measured. Statistical evaluation was carried out by ANOVA and linear regression. RESULTS: BMI, WHR and plasma DHEAS level were higher in group B vs. group A. The lowest hGH, HDL-cholesterol and the highest TNF-alpha levels were found in group BII. The relations leptin/BMI and leptin/body mass were found in each group. The inverse relation between leptin and IGFBP-1 was found in groups A and B. In group A the inverse relations leptin/HDL-cholesterol and leptin/ DHEAS were observed. In group B the direct leptin/testosterone and inverse leptin/IGF-I relations were found. In group AI the inverse leptin/DHEAS relation remained, while in group AII inverse leptin/HDL-cholesterol relation remained and reverse leptin/IGFBP-1 relation was significant. The direct leptin/testosterone, leptin/WHR and inverse leptin/TNF-alpha links were observed in group BII. CONCLUSION: The serum leptin level was linked to WHR, serum testosterone, insulin, TNF-alpha levels only in groups of perimenopausal women with such cardiovascular risk factors as high WHR, overweight, high serum TNF-alpha and testosterone levels. SN - 0033-2240 UR - https://www.unboundmedicine.com/medline/citation/17441374/[Leptin_correlates_with_distribution_of_fatty_tissue_and_plasma_levels_of_insulin_testosterone_and_tumor_necrosis_factor_alpha_in_perimenopausal_women_with_increased_testosterone_level_and_central_location_of_body_fat]_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -