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Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity.
Clin Microbiol Infect. 2007 Jul; 13(7):677-82.CM

Abstract

Taiwan has experienced several outbreaks of enterovirus 71 (EV71) infections since 1998. This study examined the quantitative relationship between specific cytokines in the cerebrospinal fluid (CSF) and the severity of EV71 brain stem encephalitis (BE), and investigated whether the CSF cytokine response differed from that to uncomplicated echovirus meningitis (EM). The study included 57 children with EV71 BE, of whom 24 had isolated BE, 24 had autonomic nervous system (ANS) dysregulation, and nine had pulmonary oedema (PE), and 15 children with EM. All were confirmed by virus culture. Mean CSF glucose, total protein and lactate levels were increased significantly in association with the severity of EV71 BE. The mean CSF concentration of interleukin (IL)-1beta in children with EV71 PE was significantly higher than in those with isolated BE. IL-6 and interferon (IFN)-gamma levels were significantly higher for EV71 PE and ANS dysregulation than for isolated BE. In contrast, EM was associated with high levels of IL-1beta and low levels of IFN-gamma. Cytokines in the central nervous system, as well as in blood, appear to be involved in the pathogenesis of EV71 BE.

Authors+Show Affiliations

Department of Emergency Medicine, National Cheng Kung University & Hospital, Tainan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17441979

Citation

Wang, S-M, et al. "Cerebrospinal Fluid Cytokines in Enterovirus 71 Brain Stem Encephalitis and Echovirus Meningitis Infections of Varying Severity." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 13, no. 7, 2007, pp. 677-82.
Wang SM, Lei HY, Su LY, et al. Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity. Clin Microbiol Infect. 2007;13(7):677-82.
Wang, S. M., Lei, H. Y., Su, L. Y., Wu, J. M., Yu, C. K., Wang, J. R., & Liu, C. C. (2007). Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 13(7), 677-82.
Wang SM, et al. Cerebrospinal Fluid Cytokines in Enterovirus 71 Brain Stem Encephalitis and Echovirus Meningitis Infections of Varying Severity. Clin Microbiol Infect. 2007;13(7):677-82. PubMed PMID: 17441979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity. AU - Wang,S-M, AU - Lei,H-Y, AU - Su,L-Y, AU - Wu,J-M, AU - Yu,C-K, AU - Wang,J-R, AU - Liu,C-C, Y1 - 2007/04/17/ PY - 2007/4/20/pubmed PY - 2007/8/8/medline PY - 2007/4/20/entrez SP - 677 EP - 82 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin Microbiol Infect VL - 13 IS - 7 N2 - Taiwan has experienced several outbreaks of enterovirus 71 (EV71) infections since 1998. This study examined the quantitative relationship between specific cytokines in the cerebrospinal fluid (CSF) and the severity of EV71 brain stem encephalitis (BE), and investigated whether the CSF cytokine response differed from that to uncomplicated echovirus meningitis (EM). The study included 57 children with EV71 BE, of whom 24 had isolated BE, 24 had autonomic nervous system (ANS) dysregulation, and nine had pulmonary oedema (PE), and 15 children with EM. All were confirmed by virus culture. Mean CSF glucose, total protein and lactate levels were increased significantly in association with the severity of EV71 BE. The mean CSF concentration of interleukin (IL)-1beta in children with EV71 PE was significantly higher than in those with isolated BE. IL-6 and interferon (IFN)-gamma levels were significantly higher for EV71 PE and ANS dysregulation than for isolated BE. In contrast, EM was associated with high levels of IL-1beta and low levels of IFN-gamma. Cytokines in the central nervous system, as well as in blood, appear to be involved in the pathogenesis of EV71 BE. SN - 1198-743X UR - https://www.unboundmedicine.com/medline/citation/17441979/Cerebrospinal_fluid_cytokines_in_enterovirus_71_brain_stem_encephalitis_and_echovirus_meningitis_infections_of_varying_severity_ DB - PRIME DP - Unbound Medicine ER -