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Panayiotopoulos syndrome: an important electroclinical example of benign childhood system epilepsy.
Epilepsia. 2007 Jun; 48(6):1044-53.E

Abstract

As a result of the converging evidence from multiple large independent studies, Panayiotopoulos syndrome (PS) is now formally recognized as a distinct clinical entity within the spectrum of benign focal epilepsies of childhood. Clinically, PS is manifested by predominantly autonomic seizures and electrographically with multifocal interictal spikes, while the few published ictal recordings have documented onsets of variable lobar topography. These typical electroclinical features do not allow straightforward assignment to a distinctive cortical area, rendering the term "focal"--as we currently understand it--problematic. This is a critical review of the clinical and EEG features of PS, focusing on those characteristics that may shed some light on its so far elusive pathophysiology. We also explore its electroclinical similarities to other idiopathic "focal" epilepsies and its differences to symptomatic focal epilepsies that may also manifest with autonomic ictal symptoms and signs. This methodology allows the formation of a rational hypothesis on the pathophysiology of PS that seems to be emerging as a good model for the so-called "system" (nonsymptomatic) epilepsies, with potentially important taxonomic implications.

Authors+Show Affiliations

Department of Clinical Neurophysiology and Epilepsies, Guy's, St Thomas' and Evelina Hospital for Children NHS Trust, London, United Kingdom. michael.koutroumanidis@gstt.nhs.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17441996

Citation

Koutroumanidis, Michael. "Panayiotopoulos Syndrome: an Important Electroclinical Example of Benign Childhood System Epilepsy." Epilepsia, vol. 48, no. 6, 2007, pp. 1044-53.
Koutroumanidis M. Panayiotopoulos syndrome: an important electroclinical example of benign childhood system epilepsy. Epilepsia. 2007;48(6):1044-53.
Koutroumanidis, M. (2007). Panayiotopoulos syndrome: an important electroclinical example of benign childhood system epilepsy. Epilepsia, 48(6), 1044-53.
Koutroumanidis M. Panayiotopoulos Syndrome: an Important Electroclinical Example of Benign Childhood System Epilepsy. Epilepsia. 2007;48(6):1044-53. PubMed PMID: 17441996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Panayiotopoulos syndrome: an important electroclinical example of benign childhood system epilepsy. A1 - Koutroumanidis,Michael, Y1 - 2007/04/18/ PY - 2007/4/20/pubmed PY - 2007/8/2/medline PY - 2007/4/20/entrez SP - 1044 EP - 53 JF - Epilepsia JO - Epilepsia VL - 48 IS - 6 N2 - As a result of the converging evidence from multiple large independent studies, Panayiotopoulos syndrome (PS) is now formally recognized as a distinct clinical entity within the spectrum of benign focal epilepsies of childhood. Clinically, PS is manifested by predominantly autonomic seizures and electrographically with multifocal interictal spikes, while the few published ictal recordings have documented onsets of variable lobar topography. These typical electroclinical features do not allow straightforward assignment to a distinctive cortical area, rendering the term "focal"--as we currently understand it--problematic. This is a critical review of the clinical and EEG features of PS, focusing on those characteristics that may shed some light on its so far elusive pathophysiology. We also explore its electroclinical similarities to other idiopathic "focal" epilepsies and its differences to symptomatic focal epilepsies that may also manifest with autonomic ictal symptoms and signs. This methodology allows the formation of a rational hypothesis on the pathophysiology of PS that seems to be emerging as a good model for the so-called "system" (nonsymptomatic) epilepsies, with potentially important taxonomic implications. SN - 0013-9580 UR - https://www.unboundmedicine.com/medline/citation/17441996/Panayiotopoulos_syndrome:_an_important_electroclinical_example_of_benign_childhood_system_epilepsy_ L2 - https://doi.org/10.1111/j.1528-1167.2007.01096.x DB - PRIME DP - Unbound Medicine ER -