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[Polymorphism of catechol-O-methyltransferase gene in relation to the risk of endometrial cancer].

Abstract

OBJECTIVE

The 4- and 16-hydroxylated metabolites of estrogens have been implicated in carcinogenesis, whereas its 2-hydroxylated metabolites have been shown to have antiangiogenic effects. We aimed to examine whether the polymorphisms of catechol-O-methyltransferase (COMT) involved in the estrogen metabolism are associated with endometrial cancer risk.

METHODS

Polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) analysis was used to study the variant allele frequency distributions of COMT Val158Met genetic polymorphism in a population based case-control study with 132 endometrial cancer cases and 110 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression after adjustment for known or suspected risk factors for endometrial cancer.

RESULTS

The most frequent genotype was COMT(Val/Val) (47.2%, 52/110) in control group and COMT(Val/Met) (58.3%, 77/132) in endometrial cancer group. The difference between the two groups was of statistical significance (P < 0.05). Compared with COMT(Met/Met) genotype, the COMT(Val/Val) genotype was inversely correlated with endometrial cancer risk, and the adjusted OR value was 0.262 (95% CI: 0.080 - 0.862, P = 0.027).

CONCLUSIONS

Among the genotypes in women in South China, genotype COMT(Val/Val) is mostly seen, followed by COMT(Val/Met), and COMT(Met/Met) is the least in control group. The endometrial cancer susceptivity of genotype COMT(Val/Val) carriers may be lower than COMT(Met/Met) carriers.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China.

    , , , , ,

    Source

    Zhonghua fu chan ke za zhi 42:2 2007 Feb pg 116-9

    MeSH

    Adult
    Catechol O-Methyltransferase
    Endometrial Neoplasms
    Female
    Gene Frequency
    Genetic Predisposition to Disease
    Genotype
    Humans
    Menopause
    Middle Aged
    Polymerase Chain Reaction
    Polymorphism, Genetic
    Polymorphism, Restriction Fragment Length
    Regression Analysis
    Risk Factors

    Pub Type(s)

    English Abstract
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    chi

    PubMed ID

    17442187

    Citation

    Zhao, Xiao-Miao, et al. "[Polymorphism of catechol-O-methyltransferase Gene in Relation to the Risk of Endometrial Cancer]." Zhonghua Fu Chan Ke Za Zhi, vol. 42, no. 2, 2007, pp. 116-9.
    Zhao XM, Xie MQ, Yang DZ, et al. [Polymorphism of catechol-O-methyltransferase gene in relation to the risk of endometrial cancer]. Zhonghua Fu Chan Ke Za Zhi. 2007;42(2):116-9.
    Zhao, X. M., Xie, M. Q., Yang, D. Z., Wang, L. A., Li, S. J., Zhuang, Y. Y., & Tang, X. L. (2007). [Polymorphism of catechol-O-methyltransferase gene in relation to the risk of endometrial cancer]. Zhonghua Fu Chan Ke Za Zhi, 42(2), pp. 116-9.
    Zhao XM, et al. [Polymorphism of catechol-O-methyltransferase Gene in Relation to the Risk of Endometrial Cancer]. Zhonghua Fu Chan Ke Za Zhi. 2007;42(2):116-9. PubMed PMID: 17442187.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Polymorphism of catechol-O-methyltransferase gene in relation to the risk of endometrial cancer]. AU - Zhao,Xiao-Miao, AU - Xie,Mei-Qing, AU - Yang,Dong-Zi, AU - Wang,Liang-An, AU - Li,Shi-Jie, AU - Zhuang,Yan-Yan, AU - Tang,Xue-Lian, PY - 2007/4/20/pubmed PY - 2007/12/7/medline PY - 2007/4/20/entrez SP - 116 EP - 9 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 42 IS - 2 N2 - OBJECTIVE: The 4- and 16-hydroxylated metabolites of estrogens have been implicated in carcinogenesis, whereas its 2-hydroxylated metabolites have been shown to have antiangiogenic effects. We aimed to examine whether the polymorphisms of catechol-O-methyltransferase (COMT) involved in the estrogen metabolism are associated with endometrial cancer risk. METHODS: Polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) analysis was used to study the variant allele frequency distributions of COMT Val158Met genetic polymorphism in a population based case-control study with 132 endometrial cancer cases and 110 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression after adjustment for known or suspected risk factors for endometrial cancer. RESULTS: The most frequent genotype was COMT(Val/Val) (47.2%, 52/110) in control group and COMT(Val/Met) (58.3%, 77/132) in endometrial cancer group. The difference between the two groups was of statistical significance (P < 0.05). Compared with COMT(Met/Met) genotype, the COMT(Val/Val) genotype was inversely correlated with endometrial cancer risk, and the adjusted OR value was 0.262 (95% CI: 0.080 - 0.862, P = 0.027). CONCLUSIONS: Among the genotypes in women in South China, genotype COMT(Val/Val) is mostly seen, followed by COMT(Val/Met), and COMT(Met/Met) is the least in control group. The endometrial cancer susceptivity of genotype COMT(Val/Val) carriers may be lower than COMT(Met/Met) carriers. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/17442187/[Polymorphism_of_catechol_O_methyltransferase_gene_in_relation_to_the_risk_of_endometrial_cancer]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0529-567X&amp;year=2007&amp;vol=42&amp;issue=2&amp;fpage=116 DB - PRIME DP - Unbound Medicine ER -