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Drug-eluting stent for the treatment of small coronary lesion: comparison between sirolimus- and paclitaxel-eluting stent.
Chin Med J (Engl). 2007 Apr 05; 120(7):569-73.CM

Abstract

BACKGROUND

Patients with small coronary lesions are at increased risk for repeat interventions after coronary angioplasty and stenting. The efficacy of drug-eluting stents (DES) has been demonstrated to improve the outcomes of these patients and is a focus of interest. Currently, two platforms of DES are available (sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES)). However, it has less been known that DES, SES vs PES, is superior for the treatment of small coronary lesions.

METHODS

In this retrospective study, 87 consecutive patients with 151 lesions underwent implantation of coronary SES (n = 68) and PES (n = 83). Quantitative coronary angiography (QCA) was performed at the time of stent implantation and subsequently at 8 months post-stenting. Small vessel disease was defined as lesions in vessels with diameter 2.5 mm measured by QCA. Major adverse cardiac events (MACE) including death, thrombosis, nonfatal myocardial infarction and target lesion revascularization (TLR) were compared between the two groups.

RESULTS

Baseline clinical characteristics and angiographic parameters were similar between the two groups. At clinical and angiographic follow-up, overall thrombosis rates were similar in both groups (0 vs 1.2%, P > 0.05). The TLR and in-segment restenosis were not significantly different (19.1% vs 25.3%; 10.3% vs 10.8%, P = 0.365 and P = 0.913 respectively) between the two groups. The in-stent restenosis rate, however, was significantly higher in the PES group (4.4% vs 21.7%; P = 0.002). Similarly, the late loss was significantly higher in the PES group ((0.140.38) mm vs (0.490.61) mm; P < 0.001).

CONCLUSIONS

In this small sample-size, non-randomized study, the data indicated that implantation of SES for the treatment of patients with small coronary lesion showed more favorable results in respect of restenosis compared with PES implantation.

Authors+Show Affiliations

Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. lijnjn@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17442204

Citation

Li, Jian-jun, et al. "Drug-eluting Stent for the Treatment of Small Coronary Lesion: Comparison Between Sirolimus- and Paclitaxel-eluting Stent." Chinese Medical Journal, vol. 120, no. 7, 2007, pp. 569-73.
Li JJ, Xu B, Yang YJ, et al. Drug-eluting stent for the treatment of small coronary lesion: comparison between sirolimus- and paclitaxel-eluting stent. Chin Med J. 2007;120(7):569-73.
Li, J. J., Xu, B., Yang, Y. J., Chen, J. L., Qiao, S. B., Ma, W. H., Qin, X. W., Yao, M., Liu, H. B., Wu, Y. J., Yuan, J. Q., Chen, J., You, S. J., Dai, J., Xia, R., & Gao, R. L. (2007). Drug-eluting stent for the treatment of small coronary lesion: comparison between sirolimus- and paclitaxel-eluting stent. Chinese Medical Journal, 120(7), 569-73.
Li JJ, et al. Drug-eluting Stent for the Treatment of Small Coronary Lesion: Comparison Between Sirolimus- and Paclitaxel-eluting Stent. Chin Med J. 2007 Apr 5;120(7):569-73. PubMed PMID: 17442204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug-eluting stent for the treatment of small coronary lesion: comparison between sirolimus- and paclitaxel-eluting stent. AU - Li,Jian-jun, AU - Xu,Bo, AU - Yang,Yue-jin, AU - Chen,Ji-lin, AU - Qiao,Shu-bin, AU - Ma,Wei-Hua, AU - Qin,Xue-wen, AU - Yao,Min, AU - Liu,Hai-bo, AU - Wu,Yong-jian, AU - Yuan,Jin-qing, AU - Chen,Jue, AU - You,Shi-jie, AU - Dai,Jun, AU - Xia,Ran, AU - Gao,Run-lin, PY - 2007/4/20/pubmed PY - 2007/5/12/medline PY - 2007/4/20/entrez SP - 569 EP - 73 JF - Chinese medical journal JO - Chin. Med. J. VL - 120 IS - 7 N2 - BACKGROUND: Patients with small coronary lesions are at increased risk for repeat interventions after coronary angioplasty and stenting. The efficacy of drug-eluting stents (DES) has been demonstrated to improve the outcomes of these patients and is a focus of interest. Currently, two platforms of DES are available (sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES)). However, it has less been known that DES, SES vs PES, is superior for the treatment of small coronary lesions. METHODS: In this retrospective study, 87 consecutive patients with 151 lesions underwent implantation of coronary SES (n = 68) and PES (n = 83). Quantitative coronary angiography (QCA) was performed at the time of stent implantation and subsequently at 8 months post-stenting. Small vessel disease was defined as lesions in vessels with diameter 2.5 mm measured by QCA. Major adverse cardiac events (MACE) including death, thrombosis, nonfatal myocardial infarction and target lesion revascularization (TLR) were compared between the two groups. RESULTS: Baseline clinical characteristics and angiographic parameters were similar between the two groups. At clinical and angiographic follow-up, overall thrombosis rates were similar in both groups (0 vs 1.2%, P > 0.05). The TLR and in-segment restenosis were not significantly different (19.1% vs 25.3%; 10.3% vs 10.8%, P = 0.365 and P = 0.913 respectively) between the two groups. The in-stent restenosis rate, however, was significantly higher in the PES group (4.4% vs 21.7%; P = 0.002). Similarly, the late loss was significantly higher in the PES group ((0.140.38) mm vs (0.490.61) mm; P < 0.001). CONCLUSIONS: In this small sample-size, non-randomized study, the data indicated that implantation of SES for the treatment of patients with small coronary lesion showed more favorable results in respect of restenosis compared with PES implantation. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/17442204/Drug_eluting_stent_for_the_treatment_of_small_coronary_lesion:_comparison_between_sirolimus__and_paclitaxel_eluting_stent_ L2 - http://Insights.ovid.com/pubmed?pmid=17442204 DB - PRIME DP - Unbound Medicine ER -