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Anti-inflammatory activity of Dalbergia lanceolaria bark ethanol extract in mice and rats.
J Ethnopharmacol. 2007 Jun 13; 112(2):300-4.JE

Abstract

Topical anti-inflammatory activity of Dalbergia lanceolaria Linn. bark ethanol extract was demonstrated in albino mice using TPA-, EPP- and AA-induced ear edema models. The systemic activity of extract was confirmed using acute and sub-acute anti-inflammatory models in albino rats. The ethanol extract exhibited significant systemic anti-inflammatory activity in Carrageenan-induced rat paw edema, by inhibition of histamine and prostaglandin phases of acute inflammation. The extract also showed significant activity against turpentine-induced exudative changes and no activity against granular tissue formation in cotton pellet-induced granuloma in albino rats. Thus, resultant anti-inflammatory activity might be due to effects on several mediators involving cyclo-oxygenase pathway resulting in prostaglandin formation and leukocyte migration from the vessels.

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Authors+Show Affiliations

Kale M
Plant Sciences Division, Agharkar Research Institute, Pune, India.
Misar AV
No affiliation info available
Dave V
No affiliation info available
Joshi M
No affiliation info available
Mujumdar AM
No affiliation info available

MeSH

AlprostadilAnimalsAnti-Inflammatory AgentsArachidonic AcidCarrageenanCotton FiberDalbergiaEar, ExternalEdemaEthanolFemaleGranulomaHistamineMaleMicePlant BarkPlant ExtractsRatsRats, WistarSerotoninSolventsTetradecanoylphorbol AcetateTurpentine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17442513

Citation

Kale, Mrudula, et al. "Anti-inflammatory Activity of Dalbergia Lanceolaria Bark Ethanol Extract in Mice and Rats." Journal of Ethnopharmacology, vol. 112, no. 2, 2007, pp. 300-4.
Kale M, Misar AV, Dave V, et al. Anti-inflammatory activity of Dalbergia lanceolaria bark ethanol extract in mice and rats. J Ethnopharmacol. 2007;112(2):300-4.
Kale, M., Misar, A. V., Dave, V., Joshi, M., & Mujumdar, A. M. (2007). Anti-inflammatory activity of Dalbergia lanceolaria bark ethanol extract in mice and rats. Journal of Ethnopharmacology, 112(2), 300-4.
Kale M, et al. Anti-inflammatory Activity of Dalbergia Lanceolaria Bark Ethanol Extract in Mice and Rats. J Ethnopharmacol. 2007 Jun 13;112(2):300-4. PubMed PMID: 17442513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory activity of Dalbergia lanceolaria bark ethanol extract in mice and rats. AU - Kale,Mrudula, AU - Misar,A V, AU - Dave,Vivek, AU - Joshi,Maruti, AU - Mujumdar,A M, Y1 - 2007/03/24/ PY - 2005/08/17/received PY - 2006/12/07/revised PY - 2007/03/09/accepted PY - 2007/4/20/pubmed PY - 2007/8/8/medline PY - 2007/4/20/entrez SP - 300 EP - 4 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 112 IS - 2 N2 - Topical anti-inflammatory activity of Dalbergia lanceolaria Linn. bark ethanol extract was demonstrated in albino mice using TPA-, EPP- and AA-induced ear edema models. The systemic activity of extract was confirmed using acute and sub-acute anti-inflammatory models in albino rats. The ethanol extract exhibited significant systemic anti-inflammatory activity in Carrageenan-induced rat paw edema, by inhibition of histamine and prostaglandin phases of acute inflammation. The extract also showed significant activity against turpentine-induced exudative changes and no activity against granular tissue formation in cotton pellet-induced granuloma in albino rats. Thus, resultant anti-inflammatory activity might be due to effects on several mediators involving cyclo-oxygenase pathway resulting in prostaglandin formation and leukocyte migration from the vessels. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17442513/Anti_inflammatory_activity_of_Dalbergia_lanceolaria_bark_ethanol_extract_in_mice_and_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00157-2 DB - PRIME DP - Unbound Medicine ER -