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Basal and postprandial gut peptides affecting food intake in lean and obese pregnant women.
J Physiol Pharmacol 2007; 58 Suppl 1:37-52JP

Abstract

Maternal obesity has been reported as a risk factor for various maternal and fetal complications. The aim of the present study was to examine the patterns of basal and postprandial plasma concentrations of certain gut hormones affecting food intake such as acylated ghrelin, peptide YY(3-36) (PYY(3-36)), cholecystokinin (CCK), insulin and glucose in pregnant women with varying body mass gain during physiological pregnancy. The study included 34 women with singleton pregnancies in the 2(nd) trimester of gestation. The examined pregnant women were divided into 4 groups; I. control pregnancy (CP) with weight gain below 0.5 kg/week; II. overweight low weight gain <1 kg/week (OLWG), III. overweight high weight gain >1 kg/week (OHWG); morbidly obese pregnant with weight gain >1.5 kg/week (MOP). The basal acylated-ghrelin levels in MOP subjects were significantly higher than those in CP and no usual suppression of acylated ghrelin after the meal observed in CP as well as in OLWG and OHWG was found in MOP women. Basal PYY(3-36) plasma levels were similar in CP, OLWG and OHWG but in MOP was significantly reduced and no significant increase in hormone level, typically observed in CP, was detected after a meal in overweight or obese women studied. The fasting CCK and C-reactive protein (CRP) levels in MOP subjects were significantly higher than those in CP and other overweight women. In conclusion, we found that pregnant women with overweight and obesity exhibit significant changes in fasting and postprandial gut hormones affecting food intake such as acylated ghrelin, PYY(3-36) and CCK as well as in CRP and these changes might contribute, at least in part, the development of obesity in pregnancy.

Authors+Show Affiliations

Department of Obstetrics and Gynecology Clinic, Ruda Slaska, Medical University of Silesia, Katowice, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17443026

Citation

Sodowski, K, et al. "Basal and Postprandial Gut Peptides Affecting Food Intake in Lean and Obese Pregnant Women." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 58 Suppl 1, 2007, pp. 37-52.
Sodowski K, Zwirska-Korczala K, Kuka D, et al. Basal and postprandial gut peptides affecting food intake in lean and obese pregnant women. J Physiol Pharmacol. 2007;58 Suppl 1:37-52.
Sodowski, K., Zwirska-Korczala, K., Kuka, D., Kukla, M., Budziszewska, P., Czuba, B., ... Konturek, P. C. (2007). Basal and postprandial gut peptides affecting food intake in lean and obese pregnant women. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 58 Suppl 1, pp. 37-52.
Sodowski K, et al. Basal and Postprandial Gut Peptides Affecting Food Intake in Lean and Obese Pregnant Women. J Physiol Pharmacol. 2007;58 Suppl 1:37-52. PubMed PMID: 17443026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Basal and postprandial gut peptides affecting food intake in lean and obese pregnant women. AU - Sodowski,K, AU - Zwirska-Korczala,K, AU - Kuka,D, AU - Kukla,M, AU - Budziszewska,P, AU - Czuba,B, AU - Włoch,A, AU - Cnota,W, AU - Bielański,W, AU - Brzozowski,T, AU - Rehfeld,J F, AU - Zdun,R, AU - Konturek,P C, PY - 2007/01/25/received PY - 2007/02/20/accepted PY - 2007/4/20/pubmed PY - 2008/1/12/medline PY - 2007/4/20/entrez SP - 37 EP - 52 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J. Physiol. Pharmacol. VL - 58 Suppl 1 N2 - Maternal obesity has been reported as a risk factor for various maternal and fetal complications. The aim of the present study was to examine the patterns of basal and postprandial plasma concentrations of certain gut hormones affecting food intake such as acylated ghrelin, peptide YY(3-36) (PYY(3-36)), cholecystokinin (CCK), insulin and glucose in pregnant women with varying body mass gain during physiological pregnancy. The study included 34 women with singleton pregnancies in the 2(nd) trimester of gestation. The examined pregnant women were divided into 4 groups; I. control pregnancy (CP) with weight gain below 0.5 kg/week; II. overweight low weight gain <1 kg/week (OLWG), III. overweight high weight gain >1 kg/week (OHWG); morbidly obese pregnant with weight gain >1.5 kg/week (MOP). The basal acylated-ghrelin levels in MOP subjects were significantly higher than those in CP and no usual suppression of acylated ghrelin after the meal observed in CP as well as in OLWG and OHWG was found in MOP women. Basal PYY(3-36) plasma levels were similar in CP, OLWG and OHWG but in MOP was significantly reduced and no significant increase in hormone level, typically observed in CP, was detected after a meal in overweight or obese women studied. The fasting CCK and C-reactive protein (CRP) levels in MOP subjects were significantly higher than those in CP and other overweight women. In conclusion, we found that pregnant women with overweight and obesity exhibit significant changes in fasting and postprandial gut hormones affecting food intake such as acylated ghrelin, PYY(3-36) and CCK as well as in CRP and these changes might contribute, at least in part, the development of obesity in pregnancy. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/17443026/Basal_and_postprandial_gut_peptides_affecting_food_intake_in_lean_and_obese_pregnant_women_ L2 - http://www.jpp.krakow.pl/journal/archive/03_07/pdf/37_03_07_article.pdf DB - PRIME DP - Unbound Medicine ER -