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Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys.
Neuropsychopharmacology. 2008 Jan; 33(2):219-25.N

Abstract

Although serotonin (5-HT) can interact with dopamine (DA) systems to modulate the subjective and reinforcing effects of psychostimulants such as cocaine and 3,4-methyldioxymethamphetamine (MDMA, ecstasy), the long-term effects of exposure to psychostimulants on brain 5-HT systems are not well characterized. The present study assessed 5-HT transporter (SERT) availability using positron emission tomography (PET) in rhesus monkeys with the SERT-specific radioligand [(11)C]3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB). SERT availability was assessed in regions of interest including the caudate nucleus, putamen, anterior cingulate cortex, and cerebellum. [(11)C]DASB distribution volume ratios (DVRs) were calculated using the cerebellum as the reference region. DVRs were calculated in control monkeys and in cocaine or MDMA self-administering monkeys approximately 24 h after the last self-administration (SA) session. SERT availability did not differ between monkeys with a history of MDMA SA and control monkeys in any region examined. In contrast, monkeys with a history of cocaine SA showed significantly higher levels of SERT availability in the caudate nucleus and putamen compared to control subjects. These results suggest that chronic SA of cocaine, but not MDMA, leads to alterations in serotonergic function in brain areas relevant to drug abuse. The higher level of SERT availability in cocaine-experienced monkeys may lead to a reduced inhibitory tone of 5-HT on the DA system, which may explain, in part, differences in the abuse liability between cocaine and MDMA.

Authors+Show Affiliations

Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17443127

Citation

Banks, Matthew L., et al. "Effects of Cocaine and MDMA Self-administration On Serotonin Transporter Availability in Monkeys." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 33, no. 2, 2008, pp. 219-25.
Banks ML, Czoty PW, Gage HD, et al. Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys. Neuropsychopharmacology. 2008;33(2):219-25.
Banks, M. L., Czoty, P. W., Gage, H. D., Bounds, M. C., Garg, P. K., Garg, S., & Nader, M. A. (2008). Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 33(2), 219-25.
Banks ML, et al. Effects of Cocaine and MDMA Self-administration On Serotonin Transporter Availability in Monkeys. Neuropsychopharmacology. 2008;33(2):219-25. PubMed PMID: 17443127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys. AU - Banks,Matthew L, AU - Czoty,Paul W, AU - Gage,H Donald, AU - Bounds,Michael C, AU - Garg,Pradeep K, AU - Garg,Sudha, AU - Nader,Michael A, Y1 - 2007/04/18/ PY - 2007/4/20/pubmed PY - 2008/2/7/medline PY - 2007/4/20/entrez SP - 219 EP - 25 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 33 IS - 2 N2 - Although serotonin (5-HT) can interact with dopamine (DA) systems to modulate the subjective and reinforcing effects of psychostimulants such as cocaine and 3,4-methyldioxymethamphetamine (MDMA, ecstasy), the long-term effects of exposure to psychostimulants on brain 5-HT systems are not well characterized. The present study assessed 5-HT transporter (SERT) availability using positron emission tomography (PET) in rhesus monkeys with the SERT-specific radioligand [(11)C]3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB). SERT availability was assessed in regions of interest including the caudate nucleus, putamen, anterior cingulate cortex, and cerebellum. [(11)C]DASB distribution volume ratios (DVRs) were calculated using the cerebellum as the reference region. DVRs were calculated in control monkeys and in cocaine or MDMA self-administering monkeys approximately 24 h after the last self-administration (SA) session. SERT availability did not differ between monkeys with a history of MDMA SA and control monkeys in any region examined. In contrast, monkeys with a history of cocaine SA showed significantly higher levels of SERT availability in the caudate nucleus and putamen compared to control subjects. These results suggest that chronic SA of cocaine, but not MDMA, leads to alterations in serotonergic function in brain areas relevant to drug abuse. The higher level of SERT availability in cocaine-experienced monkeys may lead to a reduced inhibitory tone of 5-HT on the DA system, which may explain, in part, differences in the abuse liability between cocaine and MDMA. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/17443127/Effects_of_cocaine_and_MDMA_self_administration_on_serotonin_transporter_availability_in_monkeys_ L2 - http://dx.doi.org/10.1038/sj.npp.1301420 DB - PRIME DP - Unbound Medicine ER -