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Hepatitis A. Perspectives and recent advances.

Abstract

The basis for the epidemiologic and etiologic differentiation of two major forms of viral hepatitis, hepatitis A and B, was established in a series of studies undertaken between 1930 and 1970. Final recovery and visualization of the presumed etiologic agent of hepatitis A was not, however, accomplished until the technique of immune electron microscopy was applied to the examination of specimen materials collected from individuals in the early acute stages of infection. Morphologically homogeneous virus-like particles of 27 nm diameter have now been recovered from stools of patients with hepatitis A ill from a variety of sources. Antibody to these particles has been shown to develop during the course of infection with hepatitis A but not with hepatitis B and disease has been induced in nonhuman primates inoculated with purified particle containing fractions. The classification of hepatitis A virus has not been conclusively established, but it would appear to be either a parvovirus or an enterovirus.

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  • Authors

    Source

    The American journal of pathology 81:3 1975 Dec pg 683-94

    MeSH

    Antibodies, Viral
    Enterovirus
    Hepatitis A
    Hepatovirus
    Humans
    Parvoviridae

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    174435

    Citation

    Maynard, J E.. "Hepatitis A. Perspectives and Recent Advances." The American Journal of Pathology, vol. 81, no. 3, 1975, pp. 683-94.
    Maynard JE. Hepatitis A. Perspectives and recent advances. Am J Pathol. 1975;81(3):683-94.
    Maynard, J. E. (1975). Hepatitis A. Perspectives and recent advances. The American Journal of Pathology, 81(3), pp. 683-94.
    Maynard JE. Hepatitis A. Perspectives and Recent Advances. Am J Pathol. 1975;81(3):683-94. PubMed PMID: 174435.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hepatitis A. Perspectives and recent advances. A1 - Maynard,J E, PY - 1975/12/1/pubmed PY - 1975/12/1/medline PY - 1975/12/1/entrez SP - 683 EP - 94 JF - The American journal of pathology JO - Am. J. Pathol. VL - 81 IS - 3 N2 - The basis for the epidemiologic and etiologic differentiation of two major forms of viral hepatitis, hepatitis A and B, was established in a series of studies undertaken between 1930 and 1970. Final recovery and visualization of the presumed etiologic agent of hepatitis A was not, however, accomplished until the technique of immune electron microscopy was applied to the examination of specimen materials collected from individuals in the early acute stages of infection. Morphologically homogeneous virus-like particles of 27 nm diameter have now been recovered from stools of patients with hepatitis A ill from a variety of sources. Antibody to these particles has been shown to develop during the course of infection with hepatitis A but not with hepatitis B and disease has been induced in nonhuman primates inoculated with purified particle containing fractions. The classification of hepatitis A virus has not been conclusively established, but it would appear to be either a parvovirus or an enterovirus. SN - 0002-9440 UR - https://www.unboundmedicine.com/medline/citation/174435/Hepatitis_A__Perspectives_and_recent_advances_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/174435/ DB - PRIME DP - Unbound Medicine ER -