Tags

Type your tag names separated by a space and hit enter

Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease.
Mov Disord. 2007 May 15; 22(7):990-7.MD

Abstract

Subthalamic nucleus deep brain stimulation (STN-DBS) is effective in advanced Parkinson's disease (PD), but its effects on the levodopa response are unclear. We studied the levodopa response after long-term STN-DBS, STN-DBS efficacy and predictive value of preoperative levodopa response to long-term DBS benefit in 33 PD patients with bilateral STN-DBS. Patients were assessed using the Unified Parkinson's Disease Rating Scale preoperatively (with and without medications) and postoperatively (without medications or stimulation, with only medications or stimulation, and with both medications and stimulation). Levodopa response significantly decreased postoperatively by 31.1% at 3 years and 32.3% at 5 years, possibly related to the reduction in medication requirement, direct STN stimulation effect or PD progression. STN-DBS alone significantly improved motor scores (37.2% at 3 years and 35.1% at 5 years) and activities of daily living scores (27.1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years.

Authors+Show Affiliations

Movement Disorders Center, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17443692

Citation

Piboolnurak, Panida, et al. "Levodopa Response in Long-term Bilateral Subthalamic Stimulation for Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 22, no. 7, 2007, pp. 990-7.
Piboolnurak P, Lang AE, Lozano AM, et al. Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease. Mov Disord. 2007;22(7):990-7.
Piboolnurak, P., Lang, A. E., Lozano, A. M., Miyasaki, J. M., Saint-Cyr, J. A., Poon, Y. Y., Hutchison, W. D., Dostrovsky, J. O., & Moro, E. (2007). Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 22(7), 990-7.
Piboolnurak P, et al. Levodopa Response in Long-term Bilateral Subthalamic Stimulation for Parkinson's Disease. Mov Disord. 2007 May 15;22(7):990-7. PubMed PMID: 17443692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease. AU - Piboolnurak,Panida, AU - Lang,Anthony E, AU - Lozano,Andres M, AU - Miyasaki,Janis M, AU - Saint-Cyr,Jean A, AU - Poon,Yu-Yan W, AU - Hutchison,William D, AU - Dostrovsky,Jonathan O, AU - Moro,Elena, PY - 2007/4/20/pubmed PY - 2007/8/4/medline PY - 2007/4/20/entrez SP - 990 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 22 IS - 7 N2 - Subthalamic nucleus deep brain stimulation (STN-DBS) is effective in advanced Parkinson's disease (PD), but its effects on the levodopa response are unclear. We studied the levodopa response after long-term STN-DBS, STN-DBS efficacy and predictive value of preoperative levodopa response to long-term DBS benefit in 33 PD patients with bilateral STN-DBS. Patients were assessed using the Unified Parkinson's Disease Rating Scale preoperatively (with and without medications) and postoperatively (without medications or stimulation, with only medications or stimulation, and with both medications and stimulation). Levodopa response significantly decreased postoperatively by 31.1% at 3 years and 32.3% at 5 years, possibly related to the reduction in medication requirement, direct STN stimulation effect or PD progression. STN-DBS alone significantly improved motor scores (37.2% at 3 years and 35.1% at 5 years) and activities of daily living scores (27.1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/17443692/Levodopa_response_in_long_term_bilateral_subthalamic_stimulation_for_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.21482 DB - PRIME DP - Unbound Medicine ER -