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Methimazole protects lungs during hepatic ischemia-reperfusion injury in rats: an effect not induced by hypothyroidism.
J Gastroenterol Hepatol. 2007 May; 22(5):704-9.JG

Abstract

BACKGROUND

Hepatic ischemia-reperfusion injury may lead to remote organ failure with mortal respiratory dysfunction. The aim of the present study was to analyze the possible protective effects of methimazole on lungs after hepatic ischemia-reperfusion injury.

METHODS

Forty male Wistar albino rats were randomized into five groups: a control group, in which bilateral pulmonary lobectomy was done; a hepatic ischemia-reperfusion group, in which bilateral pulmonary lobectomy was done after hepatic ischemia-reperfusion; a thyroidectomy-ischemia-reperfusion group (total thyroidectomy followed by, 7 days later, bilateral pulmonary lobectomy after hepatic ischemia-reperfusion); a methimazole-ischemia-reperfusion group (following methimazole administration for 7 days, bilateral pulmonary lobectomy was done after hepatic ischemia-reperfusion); and a methimazole +L-thyroxine-ischemia-reperfusion group (following methimazole and L-thyroxine administration for 7 days, bilateral pulmonary lobectomy was performed after hepatic ischemia-reperfusion). Pulmonary tissue specimens were evaluated histopathologically and for myeloperoxidase and malondialdehyde levels.

RESULTS

All of the ischemia-reperfusion intervention groups had higher pulmonary injury scoring indices than the control group (P < 0.001). Pulmonary injury index of the ischemia-reperfusion group was higher than that of both the methimazole-supplemented hypothyroid and euthyroid groups (P = 0028; P = 0,038, respectively) and was similar to that of the thyroidectomized group. Pulmonary tissue myeloperoxidase and malondialdehyde levels in the ischemia-reperfusion group were similar with that in the thyroidectomized rats but were significantly higher than that in the control, and both the methimazole-supplemented hypothyroid and euthyroid groups.

CONCLUSION

Methimazole exerts a protective role on lungs during hepatic ischemia-reperfusion injury, which can be attributed to its anti-inflammatory and anti-oxidant effects rather than hypothyroidism alone.

Authors+Show Affiliations

Fourth Department of Surgery, Ankara Numune Education and Research Hospital, Sihhiye, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17444859

Citation

Tütüncü, Tanju, et al. "Methimazole Protects Lungs During Hepatic Ischemia-reperfusion Injury in Rats: an Effect Not Induced By Hypothyroidism." Journal of Gastroenterology and Hepatology, vol. 22, no. 5, 2007, pp. 704-9.
Tütüncü T, Demirci C, Gözalan U, et al. Methimazole protects lungs during hepatic ischemia-reperfusion injury in rats: an effect not induced by hypothyroidism. J Gastroenterol Hepatol. 2007;22(5):704-9.
Tütüncü, T., Demirci, C., Gözalan, U., Yüksek, Y. N., Bilgihan, A., & Kama, N. A. (2007). Methimazole protects lungs during hepatic ischemia-reperfusion injury in rats: an effect not induced by hypothyroidism. Journal of Gastroenterology and Hepatology, 22(5), 704-9.
Tütüncü T, et al. Methimazole Protects Lungs During Hepatic Ischemia-reperfusion Injury in Rats: an Effect Not Induced By Hypothyroidism. J Gastroenterol Hepatol. 2007;22(5):704-9. PubMed PMID: 17444859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methimazole protects lungs during hepatic ischemia-reperfusion injury in rats: an effect not induced by hypothyroidism. AU - Tütüncü,Tanju, AU - Demirci,Cagatay, AU - Gözalan,Ugur, AU - Yüksek,Yunus Nadi, AU - Bilgihan,Ayse, AU - Kama,Nuri Aydin, PY - 2007/4/21/pubmed PY - 2007/7/18/medline PY - 2007/4/21/entrez SP - 704 EP - 9 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 22 IS - 5 N2 - BACKGROUND: Hepatic ischemia-reperfusion injury may lead to remote organ failure with mortal respiratory dysfunction. The aim of the present study was to analyze the possible protective effects of methimazole on lungs after hepatic ischemia-reperfusion injury. METHODS: Forty male Wistar albino rats were randomized into five groups: a control group, in which bilateral pulmonary lobectomy was done; a hepatic ischemia-reperfusion group, in which bilateral pulmonary lobectomy was done after hepatic ischemia-reperfusion; a thyroidectomy-ischemia-reperfusion group (total thyroidectomy followed by, 7 days later, bilateral pulmonary lobectomy after hepatic ischemia-reperfusion); a methimazole-ischemia-reperfusion group (following methimazole administration for 7 days, bilateral pulmonary lobectomy was done after hepatic ischemia-reperfusion); and a methimazole +L-thyroxine-ischemia-reperfusion group (following methimazole and L-thyroxine administration for 7 days, bilateral pulmonary lobectomy was performed after hepatic ischemia-reperfusion). Pulmonary tissue specimens were evaluated histopathologically and for myeloperoxidase and malondialdehyde levels. RESULTS: All of the ischemia-reperfusion intervention groups had higher pulmonary injury scoring indices than the control group (P < 0.001). Pulmonary injury index of the ischemia-reperfusion group was higher than that of both the methimazole-supplemented hypothyroid and euthyroid groups (P = 0028; P = 0,038, respectively) and was similar to that of the thyroidectomized group. Pulmonary tissue myeloperoxidase and malondialdehyde levels in the ischemia-reperfusion group were similar with that in the thyroidectomized rats but were significantly higher than that in the control, and both the methimazole-supplemented hypothyroid and euthyroid groups. CONCLUSION: Methimazole exerts a protective role on lungs during hepatic ischemia-reperfusion injury, which can be attributed to its anti-inflammatory and anti-oxidant effects rather than hypothyroidism alone. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/17444859/Methimazole_protects_lungs_during_hepatic_ischemia_reperfusion_injury_in_rats:_an_effect_not_induced_by_hypothyroidism_ L2 - https://doi.org/10.1111/j.1440-1746.2006.04202.x DB - PRIME DP - Unbound Medicine ER -