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Impact of low-density lipoprotein particle size on carotid intima-media thickness in patients with type 2 diabetes mellitus.
Metabolism 2007; 56(5):608-13M

Abstract

Small low-density lipoprotein (LDL) particles and modifications to LDL such as glycation and oxidation have been linked to the pathogenesis of atherosclerosis in patients with diabetes. We investigated whether LDL particle size, or the levels of glycated LDL or malondialdehyde-modified LDL (MDA-LDL) are associated with carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus. One hundred seventy-two patients with type 2 diabetes mellitus were enrolled. Carotid IMT was measured by high-resolution ultrasound, and LDL particle size and serum glycated LDL and MDA-LDL levels were determined. The 3 variables were significantly correlated with one another. Univariate analyses defined statistically significant correlations of carotid IMT with LDL size, hemoglobin A(1c), glycated LDL, MDA-LDL, high-density lipoprotein (HDL) cholesterol, and age. The strongest association of IMT was with LDL size (r = -0.406, P < .0001), followed by that with HDL cholesterol (r = -0.225, P = .004). A stepwise multiple regression analysis revealed that LDL size and HDL cholesterol are independent predictors of carotid IMT. Neither glycated LDL nor MDA-LDL had a significant independent contribution to the severity of carotid IMT in the multivariate model. Low-density lipoprotein particle size, but not the glycated LDL or MDA-LDL level, was independently associated with carotid IMT in patients with type 2 diabetes mellitus regardless of antidiabetic and lipid-lowering medications. These results suggest that the measurement of LDL size may be more useful than quantification of modified LDLs for assessing atherosclerosis in patients with type 2 diabetes mellitus. Small LDL particles may be the most important predictor for the risk of cardiovascular disease in diabetic patients.

Authors+Show Affiliations

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17445534

Citation

Hayashi, Yuzo, et al. "Impact of Low-density Lipoprotein Particle Size On Carotid Intima-media Thickness in Patients With Type 2 Diabetes Mellitus." Metabolism: Clinical and Experimental, vol. 56, no. 5, 2007, pp. 608-13.
Hayashi Y, Okumura K, Matsui H, et al. Impact of low-density lipoprotein particle size on carotid intima-media thickness in patients with type 2 diabetes mellitus. Metab Clin Exp. 2007;56(5):608-13.
Hayashi, Y., Okumura, K., Matsui, H., Imamura, A., Miura, M., Takahashi, R., ... Murohara, T. (2007). Impact of low-density lipoprotein particle size on carotid intima-media thickness in patients with type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 56(5), pp. 608-13.
Hayashi Y, et al. Impact of Low-density Lipoprotein Particle Size On Carotid Intima-media Thickness in Patients With Type 2 Diabetes Mellitus. Metab Clin Exp. 2007;56(5):608-13. PubMed PMID: 17445534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of low-density lipoprotein particle size on carotid intima-media thickness in patients with type 2 diabetes mellitus. AU - Hayashi,Yuzo, AU - Okumura,Kenji, AU - Matsui,Hideo, AU - Imamura,Akiko, AU - Miura,Manabu, AU - Takahashi,Ryotaro, AU - Murakami,Ryuichiro, AU - Ogawa,Yasuhiro, AU - Numaguchi,Yasushi, AU - Murohara,Toyoaki, PY - 2007/4/21/pubmed PY - 2007/5/26/medline PY - 2007/4/21/entrez SP - 608 EP - 13 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 56 IS - 5 N2 - Small low-density lipoprotein (LDL) particles and modifications to LDL such as glycation and oxidation have been linked to the pathogenesis of atherosclerosis in patients with diabetes. We investigated whether LDL particle size, or the levels of glycated LDL or malondialdehyde-modified LDL (MDA-LDL) are associated with carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus. One hundred seventy-two patients with type 2 diabetes mellitus were enrolled. Carotid IMT was measured by high-resolution ultrasound, and LDL particle size and serum glycated LDL and MDA-LDL levels were determined. The 3 variables were significantly correlated with one another. Univariate analyses defined statistically significant correlations of carotid IMT with LDL size, hemoglobin A(1c), glycated LDL, MDA-LDL, high-density lipoprotein (HDL) cholesterol, and age. The strongest association of IMT was with LDL size (r = -0.406, P < .0001), followed by that with HDL cholesterol (r = -0.225, P = .004). A stepwise multiple regression analysis revealed that LDL size and HDL cholesterol are independent predictors of carotid IMT. Neither glycated LDL nor MDA-LDL had a significant independent contribution to the severity of carotid IMT in the multivariate model. Low-density lipoprotein particle size, but not the glycated LDL or MDA-LDL level, was independently associated with carotid IMT in patients with type 2 diabetes mellitus regardless of antidiabetic and lipid-lowering medications. These results suggest that the measurement of LDL size may be more useful than quantification of modified LDLs for assessing atherosclerosis in patients with type 2 diabetes mellitus. Small LDL particles may be the most important predictor for the risk of cardiovascular disease in diabetic patients. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/17445534/Impact_of_low_density_lipoprotein_particle_size_on_carotid_intima_media_thickness_in_patients_with_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(07)00020-0 DB - PRIME DP - Unbound Medicine ER -