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Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus.
Metabolism. 2007 May; 56(5):623-8.M

Abstract

There have been several reports about associations of serum leptin or adiponectin with bone mineral density and biochemical markers of bone turnover. However, the precise roles of adipocytokines in bone metabolism have not been fully elucidated. We investigated the associations of serum level of leptin or adiponectin with bone mineral density, serum osteocalcin, and urinary N-terminal telopeptide of type I collagen (NTX) in 40 Japanese patients with type 2 diabetes mellitus. Bone mineral density was measured by using dual-energy x-ray absorptiometry at different sites (distal radius, femoral neck, and lumbar spine) and was expressed as z score. Multiple regression analysis revealed that there were significant positive correlations between serum leptin or adiponectin level and z score at the distal radius, but not at the femoral neck or the lumbar spine. Although no correlation was observed between serum leptin and serum osteocalcin, there was a significant negative correlation between serum leptin and urinary NTX, a marker of bone resorption. No correlation was observed between serum adiponectin and serum osteocalcin or urinary NTX. These results indicate that leptin and adiponectin may have a protective effect on bone metabolism in patients with type 2 diabetes mellitus.

Authors+Show Affiliations

Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17445536

Citation

Tamura, Tomoko, et al. "Serum Leptin and Adiponectin Are Positively Associated With Bone Mineral Density at the Distal Radius in Patients With Type 2 Diabetes Mellitus." Metabolism: Clinical and Experimental, vol. 56, no. 5, 2007, pp. 623-8.
Tamura T, Yoneda M, Yamane K, et al. Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus. Metabolism. 2007;56(5):623-8.
Tamura, T., Yoneda, M., Yamane, K., Nakanishi, S., Nakashima, R., Okubo, M., & Kohno, N. (2007). Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 56(5), 623-8.
Tamura T, et al. Serum Leptin and Adiponectin Are Positively Associated With Bone Mineral Density at the Distal Radius in Patients With Type 2 Diabetes Mellitus. Metabolism. 2007;56(5):623-8. PubMed PMID: 17445536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus. AU - Tamura,Tomoko, AU - Yoneda,Masayasu, AU - Yamane,Kiminori, AU - Nakanishi,Shuhei, AU - Nakashima,Reiko, AU - Okubo,Masamichi, AU - Kohno,Nobuoki, PY - 2005/10/18/received PY - 2006/12/18/accepted PY - 2007/4/21/pubmed PY - 2007/5/26/medline PY - 2007/4/21/entrez SP - 623 EP - 8 JF - Metabolism: clinical and experimental JO - Metabolism VL - 56 IS - 5 N2 - There have been several reports about associations of serum leptin or adiponectin with bone mineral density and biochemical markers of bone turnover. However, the precise roles of adipocytokines in bone metabolism have not been fully elucidated. We investigated the associations of serum level of leptin or adiponectin with bone mineral density, serum osteocalcin, and urinary N-terminal telopeptide of type I collagen (NTX) in 40 Japanese patients with type 2 diabetes mellitus. Bone mineral density was measured by using dual-energy x-ray absorptiometry at different sites (distal radius, femoral neck, and lumbar spine) and was expressed as z score. Multiple regression analysis revealed that there were significant positive correlations between serum leptin or adiponectin level and z score at the distal radius, but not at the femoral neck or the lumbar spine. Although no correlation was observed between serum leptin and serum osteocalcin, there was a significant negative correlation between serum leptin and urinary NTX, a marker of bone resorption. No correlation was observed between serum adiponectin and serum osteocalcin or urinary NTX. These results indicate that leptin and adiponectin may have a protective effect on bone metabolism in patients with type 2 diabetes mellitus. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/17445536/Serum_leptin_and_adiponectin_are_positively_associated_with_bone_mineral_density_at_the_distal_radius_in_patients_with_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(07)00024-8 DB - PRIME DP - Unbound Medicine ER -