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Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III).
Urology 2007; 69(4):708-13U

Abstract

OBJECTIVES

To evaluate the association of circulating sex steroid hormones and sex hormone binding globulin (SHBG) with lower urinary tract symptoms (LUTS).

METHODS

We included 260 men, 60 years old or older, who participated in Phase 1 (1988 to 1991) of the Third National Health and Nutrition Examination Survey and for whom surplus serum was available. We measured the serum concentrations of testosterone, androstanediol glucuronide (AAG), estradiol, and SHBG. Free testosterone was calculated from the circulating testosterone, SHBG, and albumin. The cases (n = 128) were men with two to four symptoms (nocturia, hesitancy, incomplete emptying, and weak stream), but who had never undergone noncancer prostate surgery. The controls (n = 132) were men who neither had symptoms nor had undergone noncancer prostate surgery. We adjusted for age, race/ethnicity, waist circumference, cigarette smoking, alcohol consumption, and physical activity in logistic regression models and used sampling weights.

RESULTS

The cases had statistically significantly greater AAG and estradiol concentrations than did the controls. After multivariate adjustment, the men in the top tertile of AAG (odds ratio 2.62, 95% confidence interval 1.12 to 6.14) had a greater risk of LUTS compared with men in the bottom two tertiles. Also, men with a greater estradiol concentration (odds ratio 1.78, 95% confidence interval 0.91 to 3.49) and a greater estradiol/SHBG molar ratio (odds ratio 2.41, 95% confidence interval 1.39 to 4.17) had a greater risk of LUTS than did men with lower concentrations. No consistent associations were seen for circulating testosterone, free testosterone, or SHBG.

CONCLUSIONS

In this cross-sectional study representative of older U.S. men, circulating AAG, a metabolite of dihydrotestosterone, and estradiol were associated with an increased risk of having LUTS.

Authors+Show Affiliations

Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17445656

Citation

Rohrmann, Sabine, et al. "Serum Sex Steroid Hormones and Lower Urinary Tract Symptoms in Third National Health and Nutrition Examination Survey (NHANES III)." Urology, vol. 69, no. 4, 2007, pp. 708-13.
Rohrmann S, Nelson WG, Rifai N, et al. Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III). Urology. 2007;69(4):708-13.
Rohrmann, S., Nelson, W. G., Rifai, N., Kanarek, N., Basaria, S., Tsilidis, K. K., ... Platz, E. A. (2007). Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III). Urology, 69(4), pp. 708-13.
Rohrmann S, et al. Serum Sex Steroid Hormones and Lower Urinary Tract Symptoms in Third National Health and Nutrition Examination Survey (NHANES III). Urology. 2007;69(4):708-13. PubMed PMID: 17445656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III). AU - Rohrmann,Sabine, AU - Nelson,William G, AU - Rifai,Nader, AU - Kanarek,Norma, AU - Basaria,Shehzad, AU - Tsilidis,Konstantinos K, AU - Smit,Ellen, AU - Giovannucci,Edward, AU - Platz,Elizabeth A, PY - 2006/07/19/received PY - 2006/10/09/revised PY - 2007/01/05/accepted PY - 2007/4/21/pubmed PY - 2007/5/26/medline PY - 2007/4/21/entrez SP - 708 EP - 13 JF - Urology JO - Urology VL - 69 IS - 4 N2 - OBJECTIVES: To evaluate the association of circulating sex steroid hormones and sex hormone binding globulin (SHBG) with lower urinary tract symptoms (LUTS). METHODS: We included 260 men, 60 years old or older, who participated in Phase 1 (1988 to 1991) of the Third National Health and Nutrition Examination Survey and for whom surplus serum was available. We measured the serum concentrations of testosterone, androstanediol glucuronide (AAG), estradiol, and SHBG. Free testosterone was calculated from the circulating testosterone, SHBG, and albumin. The cases (n = 128) were men with two to four symptoms (nocturia, hesitancy, incomplete emptying, and weak stream), but who had never undergone noncancer prostate surgery. The controls (n = 132) were men who neither had symptoms nor had undergone noncancer prostate surgery. We adjusted for age, race/ethnicity, waist circumference, cigarette smoking, alcohol consumption, and physical activity in logistic regression models and used sampling weights. RESULTS: The cases had statistically significantly greater AAG and estradiol concentrations than did the controls. After multivariate adjustment, the men in the top tertile of AAG (odds ratio 2.62, 95% confidence interval 1.12 to 6.14) had a greater risk of LUTS compared with men in the bottom two tertiles. Also, men with a greater estradiol concentration (odds ratio 1.78, 95% confidence interval 0.91 to 3.49) and a greater estradiol/SHBG molar ratio (odds ratio 2.41, 95% confidence interval 1.39 to 4.17) had a greater risk of LUTS than did men with lower concentrations. No consistent associations were seen for circulating testosterone, free testosterone, or SHBG. CONCLUSIONS: In this cross-sectional study representative of older U.S. men, circulating AAG, a metabolite of dihydrotestosterone, and estradiol were associated with an increased risk of having LUTS. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/17445656/Serum_sex_steroid_hormones_and_lower_urinary_tract_symptoms_in_Third_National_Health_and_Nutrition_Examination_Survey__NHANES_III__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(07)00012-X DB - PRIME DP - Unbound Medicine ER -