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Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone.
Fertil Steril. 2007 Nov; 88(5):1382-8.FS

Abstract

OBJECTIVE

To evaluate the effect of different human chorionic gonadotropin (hCG) doses on the ongoing pregnancy rates in patients with polycystic ovary syndrome (PCOS).

DESIGN

Prospective, randomized, controlled trial.

SETTING

Tertiary university referral center.

PATIENT(S)

Eighty PCOS patients.

INTERVENTION(S)

Patients were randomized to receive 10,000 IU (n = 28), 5000 IU (n = 26), or 2500 IU (n = 26) of hCG for triggering final oocyte maturation as soon as >or=3 or more follicles of 17 mm or larger were present at ultrasound. Patients were stimulated with recombinant follicle stimulating hormone (FSH) and daily gonadotropin-releasing hormone (GnRH) antagonist, starting on day 6 of stimulation.

MAIN OUTCOME MEASURE(S)

Ongoing pregnancy, fertilization rates.

RESULT(S)

The median fertilization rates were 52.8%, 65.4%, and 55.6% after administration of 10,000 IU, 5000 IU and 2500 IU, respectively. The ongoing pregnancy rates per PCOS patient receiving hCG were 26.9% (7 of 26), 30.8% (8 of 26) and 34.8% (8 of 23), respectively.

CONCLUSION(S)

A decrease in the dose of hCG used to trigger final oocyte maturation does not appear to affect adversely the probability of pregnancy in PCOS patients treated by IVF using GnRH antagonists and recombinant FSH, and further testing in future larger-scale trials is recommended.

Authors+Show Affiliations

Centre for Reproductive Medicine, Vrije Universiteit Brussel, Brussels, Belgium. stratis.kolibianakis@irg.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17445806

Citation

Kolibianakis, Efstratios M., et al. "Triggering Final Oocyte Maturation Using Different Doses of Human Chorionic Gonadotropin: a Randomized Pilot Study in Patients With Polycystic Ovary Syndrome Treated With Gonadotropin-releasing Hormone Antagonists and Recombinant Follicle-stimulating Hormone." Fertility and Sterility, vol. 88, no. 5, 2007, pp. 1382-8.
Kolibianakis EM, Papanikolaou EG, Tournaye H, et al. Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone. Fertil Steril. 2007;88(5):1382-8.
Kolibianakis, E. M., Papanikolaou, E. G., Tournaye, H., Camus, M., Van Steirteghem, A. C., & Devroey, P. (2007). Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone. Fertility and Sterility, 88(5), 1382-8.
Kolibianakis EM, et al. Triggering Final Oocyte Maturation Using Different Doses of Human Chorionic Gonadotropin: a Randomized Pilot Study in Patients With Polycystic Ovary Syndrome Treated With Gonadotropin-releasing Hormone Antagonists and Recombinant Follicle-stimulating Hormone. Fertil Steril. 2007;88(5):1382-8. PubMed PMID: 17445806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone. AU - Kolibianakis,Efstratios M, AU - Papanikolaou,Evangelos G, AU - Tournaye,Herman, AU - Camus,Michel, AU - Van Steirteghem,Andre C, AU - Devroey,Paul, Y1 - 2007/04/18/ PY - 2006/08/26/received PY - 2006/12/17/revised PY - 2006/12/17/accepted PY - 2007/4/21/pubmed PY - 2007/12/12/medline PY - 2007/4/21/entrez SP - 1382 EP - 8 JF - Fertility and sterility JO - Fertil. Steril. VL - 88 IS - 5 N2 - OBJECTIVE: To evaluate the effect of different human chorionic gonadotropin (hCG) doses on the ongoing pregnancy rates in patients with polycystic ovary syndrome (PCOS). DESIGN: Prospective, randomized, controlled trial. SETTING: Tertiary university referral center. PATIENT(S): Eighty PCOS patients. INTERVENTION(S): Patients were randomized to receive 10,000 IU (n = 28), 5000 IU (n = 26), or 2500 IU (n = 26) of hCG for triggering final oocyte maturation as soon as >or=3 or more follicles of 17 mm or larger were present at ultrasound. Patients were stimulated with recombinant follicle stimulating hormone (FSH) and daily gonadotropin-releasing hormone (GnRH) antagonist, starting on day 6 of stimulation. MAIN OUTCOME MEASURE(S): Ongoing pregnancy, fertilization rates. RESULT(S): The median fertilization rates were 52.8%, 65.4%, and 55.6% after administration of 10,000 IU, 5000 IU and 2500 IU, respectively. The ongoing pregnancy rates per PCOS patient receiving hCG were 26.9% (7 of 26), 30.8% (8 of 26) and 34.8% (8 of 23), respectively. CONCLUSION(S): A decrease in the dose of hCG used to trigger final oocyte maturation does not appear to affect adversely the probability of pregnancy in PCOS patients treated by IVF using GnRH antagonists and recombinant FSH, and further testing in future larger-scale trials is recommended. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17445806/Triggering_final_oocyte_maturation_using_different_doses_of_human_chorionic_gonadotropin:_a_randomized_pilot_study_in_patients_with_polycystic_ovary_syndrome_treated_with_gonadotropin_releasing_hormone_antagonists_and_recombinant_follicle_stimulating_hormone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)00110-0 DB - PRIME DP - Unbound Medicine ER -