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Does diagnosis of the metabolic syndrome detect further men at high risk of cardiovascular death beyond those identified by a conventional cardiovascular risk score? The DECODE Study.
Eur J Cardiovasc Prev Rehabil. 2007 Apr; 14(2):192-9.EJ

Abstract

BACKGROUND

It is not known whether the metabolic syndrome detects further individuals at high risk of death from cardiovascular disease (CVD), beyond those identified by a conventional cardiovascular risk score.

DESIGN

A prospective study.

METHODS

A total of 2790 men without diabetes, aged 50-69 years from seven population-based European cohorts participating in the DECODE Study, were followed for CVD mortality over 10 years.

RESULTS

Some 51% of the men had an estimated 10-year risk of fatal CVD under 5%, using the European SCORE project equation, and 22% of them had the metabolic syndrome, as defined by the National Cholesterol Education Program Adult Treatment Panel III. In the low-risk men, the hazards ratio for fatal CVD, after adjusting for age and study centre, was 2.71 (1.33-5.51) for men with the syndrome (P<0.01) compared with men without the syndrome. A large waist circumference (>102 cm) carried an odds ratio of 2.24 (1.05-4.76) in the low CVD risk men.

CONCLUSIONS

Men with a low cardiovascular risk score and the metabolic syndrome had a significantly higher risk of fatal CVD than those without the syndrome. The use of the metabolic syndrome in clinical practice is thus justified in men, but waist circumference provided a simpler diagnostic tool with similar fatal CVD risk in these low-risk men. A large waist circumference could be used for prescreening, and could be included in CVD risk scores.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17446796

Citation

DECODE Study Group. "Does Diagnosis of the Metabolic Syndrome Detect Further Men at High Risk of Cardiovascular Death Beyond Those Identified By a Conventional Cardiovascular Risk Score? the DECODE Study." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 14, no. 2, 2007, pp. 192-9.
DECODE Study Group. Does diagnosis of the metabolic syndrome detect further men at high risk of cardiovascular death beyond those identified by a conventional cardiovascular risk score? The DECODE Study. Eur J Cardiovasc Prev Rehabil. 2007;14(2):192-9.
DECODE Study Group. (2007). Does diagnosis of the metabolic syndrome detect further men at high risk of cardiovascular death beyond those identified by a conventional cardiovascular risk score? The DECODE Study. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 14(2), 192-9.
DECODE Study Group. Does Diagnosis of the Metabolic Syndrome Detect Further Men at High Risk of Cardiovascular Death Beyond Those Identified By a Conventional Cardiovascular Risk Score? the DECODE Study. Eur J Cardiovasc Prev Rehabil. 2007;14(2):192-9. PubMed PMID: 17446796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does diagnosis of the metabolic syndrome detect further men at high risk of cardiovascular death beyond those identified by a conventional cardiovascular risk score? The DECODE Study. A1 - ,, PY - 2007/4/21/pubmed PY - 2007/9/21/medline PY - 2007/4/21/entrez SP - 192 EP - 9 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 14 IS - 2 N2 - BACKGROUND: It is not known whether the metabolic syndrome detects further individuals at high risk of death from cardiovascular disease (CVD), beyond those identified by a conventional cardiovascular risk score. DESIGN: A prospective study. METHODS: A total of 2790 men without diabetes, aged 50-69 years from seven population-based European cohorts participating in the DECODE Study, were followed for CVD mortality over 10 years. RESULTS: Some 51% of the men had an estimated 10-year risk of fatal CVD under 5%, using the European SCORE project equation, and 22% of them had the metabolic syndrome, as defined by the National Cholesterol Education Program Adult Treatment Panel III. In the low-risk men, the hazards ratio for fatal CVD, after adjusting for age and study centre, was 2.71 (1.33-5.51) for men with the syndrome (P<0.01) compared with men without the syndrome. A large waist circumference (>102 cm) carried an odds ratio of 2.24 (1.05-4.76) in the low CVD risk men. CONCLUSIONS: Men with a low cardiovascular risk score and the metabolic syndrome had a significantly higher risk of fatal CVD than those without the syndrome. The use of the metabolic syndrome in clinical practice is thus justified in men, but waist circumference provided a simpler diagnostic tool with similar fatal CVD risk in these low-risk men. A large waist circumference could be used for prescreening, and could be included in CVD risk scores. SN - 1741-8267 UR - https://www.unboundmedicine.com/medline/citation/17446796/Does_diagnosis_of_the_metabolic_syndrome_detect_further_men_at_high_risk_of_cardiovascular_death_beyond_those_identified_by_a_conventional_cardiovascular_risk_score_The_DECODE_Study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=17446796.ui DB - PRIME DP - Unbound Medicine ER -