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Smoking cessation and risk of type 2 diabetes mellitus: Korea Medical Insurance Corporation Study.
Eur J Cardiovasc Prev Rehabil 2007; 14(2):244-9EJ

Abstract

BACKGROUND

To investigate the independent effects of smoking cessation on the risk for developing type 2 diabetes mellitus (DM) in the general population.

DESIGN

An 8-year prospective study.

METHODS

This prospective study started with baseline examinations in 1990 and 1992, and continued with follow-up examinations every 2 years up to 1998 and 2000. A total of 27 635 nondiabetic men, aged 35-44 years were classified as 5701 nonsmokers, 7477 ex-smokers and 14 457 sustained smokers, based on repeated self-reported questionnaires in 1992, 1994 and 1996. Baseline fasting serum glucose level and other risk factors were measured in 1990 and 1992. The outcome was newly developed DM, defined as a fasting glucose level > or =7.0 mmol/l in 1998 and 2000 (averaged).

RESULTS

Over the 8 years, 1170 men (4.2%) developed DM. When compared with nonsmokers, the fully adjusted risk ratio of ex-smokers and sustained smokers for diabetes was 1.22 [95% confidence interval (CI), 0.96-1.55] and 1.60 (95% CI, 1.29-1.97), respectively. Among the ex-smokers, the risk for diabetes differed according to the quit-smoking period. Compared with nonsmokers, the fully adjusted risk ratio for DM in men who quit smoking before 1992, during 1992-1993 and during 1994-1995 was 0.95 (0.72-1.25), 1.44 (0.96-2.15) and 2.13 (1.51-3.00), respectively, after adjustment for age, baseline fasting serum glucose, weight change, baseline body mass index, family history of DM, alcohol consumption and exercise status.

CONCLUSIONS

Our results support cigarette smoking as an independent and modifiable risk factor for DM. Early smoking cessation could decrease the risk for developing DM to that of nonsmokers in the long term.

Authors+Show Affiliations

Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17446803

Citation

Hur, Nam Wook, et al. "Smoking Cessation and Risk of Type 2 Diabetes Mellitus: Korea Medical Insurance Corporation Study." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 14, no. 2, 2007, pp. 244-9.
Hur NW, Kim HC, Nam CM, et al. Smoking cessation and risk of type 2 diabetes mellitus: Korea Medical Insurance Corporation Study. Eur J Cardiovasc Prev Rehabil. 2007;14(2):244-9.
Hur, N. W., Kim, H. C., Nam, C. M., Jee, S. H., Lee, H. C., & Suh, I. (2007). Smoking cessation and risk of type 2 diabetes mellitus: Korea Medical Insurance Corporation Study. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 14(2), pp. 244-9.
Hur NW, et al. Smoking Cessation and Risk of Type 2 Diabetes Mellitus: Korea Medical Insurance Corporation Study. Eur J Cardiovasc Prev Rehabil. 2007;14(2):244-9. PubMed PMID: 17446803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking cessation and risk of type 2 diabetes mellitus: Korea Medical Insurance Corporation Study. AU - Hur,Nam Wook, AU - Kim,Hyeon Chang, AU - Nam,Chung Mo, AU - Jee,Sun Ha, AU - Lee,Hyun Chul, AU - Suh,Il, PY - 2007/4/21/pubmed PY - 2007/9/21/medline PY - 2007/4/21/entrez SP - 244 EP - 9 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 14 IS - 2 N2 - BACKGROUND: To investigate the independent effects of smoking cessation on the risk for developing type 2 diabetes mellitus (DM) in the general population. DESIGN: An 8-year prospective study. METHODS: This prospective study started with baseline examinations in 1990 and 1992, and continued with follow-up examinations every 2 years up to 1998 and 2000. A total of 27 635 nondiabetic men, aged 35-44 years were classified as 5701 nonsmokers, 7477 ex-smokers and 14 457 sustained smokers, based on repeated self-reported questionnaires in 1992, 1994 and 1996. Baseline fasting serum glucose level and other risk factors were measured in 1990 and 1992. The outcome was newly developed DM, defined as a fasting glucose level > or =7.0 mmol/l in 1998 and 2000 (averaged). RESULTS: Over the 8 years, 1170 men (4.2%) developed DM. When compared with nonsmokers, the fully adjusted risk ratio of ex-smokers and sustained smokers for diabetes was 1.22 [95% confidence interval (CI), 0.96-1.55] and 1.60 (95% CI, 1.29-1.97), respectively. Among the ex-smokers, the risk for diabetes differed according to the quit-smoking period. Compared with nonsmokers, the fully adjusted risk ratio for DM in men who quit smoking before 1992, during 1992-1993 and during 1994-1995 was 0.95 (0.72-1.25), 1.44 (0.96-2.15) and 2.13 (1.51-3.00), respectively, after adjustment for age, baseline fasting serum glucose, weight change, baseline body mass index, family history of DM, alcohol consumption and exercise status. CONCLUSIONS: Our results support cigarette smoking as an independent and modifiable risk factor for DM. Early smoking cessation could decrease the risk for developing DM to that of nonsmokers in the long term. SN - 1741-8267 UR - https://www.unboundmedicine.com/medline/citation/17446803/Smoking_cessation_and_risk_of_type_2_diabetes_mellitus:_Korea_Medical_Insurance_Corporation_Study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=17446803.ui DB - PRIME DP - Unbound Medicine ER -