Tags

Type your tag names separated by a space and hit enter

Rapid inhibitory effect of corticosterone on histamine release from rat peritoneal mast cells.
Horm Metab Res. 2007 Apr; 39(4):273-7.HM

Abstract

Glucocorticoids are steroids endowed with powerful anti-inflammatory properties, which are routinely believed to require several hours to take effect through modulation of gene expression. Our recent report has shown that glucocorticoids could inhibit allergic reaction within 10 minutes, which the classical genomic mechanism could not explain. Histamine is thought to be one of major mediators in the allergic reaction, and IgE-mediated histamine release from mast cells plays a pivotal role in allergic diseases. Here, we have determined a rapid effect of corticosterone on histamine release from rat peritoneal mast cells, using fluorometric assay. The results showed that corticosterone could inhibit antigen-induced histamine release from rat peritoneal cells within 15 minutes (p<0.05), which could be mimicked by membrane-impermeable BSA conjugated corticosterone (p<0.05). Neither glucocorticoid nuclear receptor antagonist nor protein synthesis inhibitor could block the rapid action (p<0.05). The study provided evidence that nongenomic mechanism might be involved in rapid effect of glucocorticoids on mast cells in allergic disease.

Authors+Show Affiliations

Laboratory of Stress Medicine, Second Military Medical University, Shanghai, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17447165

Citation

Liu, C, et al. "Rapid Inhibitory Effect of Corticosterone On Histamine Release From Rat Peritoneal Mast Cells." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 39, no. 4, 2007, pp. 273-7.
Liu C, Zhou J, Zhang LD, et al. Rapid inhibitory effect of corticosterone on histamine release from rat peritoneal mast cells. Horm Metab Res. 2007;39(4):273-7.
Liu, C., Zhou, J., Zhang, L. D., Wang, Y. X., Kang, Z. M., Chen, Y. Z., & Jiang, C. L. (2007). Rapid inhibitory effect of corticosterone on histamine release from rat peritoneal mast cells. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 39(4), 273-7.
Liu C, et al. Rapid Inhibitory Effect of Corticosterone On Histamine Release From Rat Peritoneal Mast Cells. Horm Metab Res. 2007;39(4):273-7. PubMed PMID: 17447165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid inhibitory effect of corticosterone on histamine release from rat peritoneal mast cells. AU - Liu,C, AU - Zhou,J, AU - Zhang,L-D, AU - Wang,Y-X, AU - Kang,Z-M, AU - Chen,Y-Z, AU - Jiang,C-L, PY - 2007/4/21/pubmed PY - 2007/6/21/medline PY - 2007/4/21/entrez SP - 273 EP - 7 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 39 IS - 4 N2 - Glucocorticoids are steroids endowed with powerful anti-inflammatory properties, which are routinely believed to require several hours to take effect through modulation of gene expression. Our recent report has shown that glucocorticoids could inhibit allergic reaction within 10 minutes, which the classical genomic mechanism could not explain. Histamine is thought to be one of major mediators in the allergic reaction, and IgE-mediated histamine release from mast cells plays a pivotal role in allergic diseases. Here, we have determined a rapid effect of corticosterone on histamine release from rat peritoneal mast cells, using fluorometric assay. The results showed that corticosterone could inhibit antigen-induced histamine release from rat peritoneal cells within 15 minutes (p<0.05), which could be mimicked by membrane-impermeable BSA conjugated corticosterone (p<0.05). Neither glucocorticoid nuclear receptor antagonist nor protein synthesis inhibitor could block the rapid action (p<0.05). The study provided evidence that nongenomic mechanism might be involved in rapid effect of glucocorticoids on mast cells in allergic disease. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/17447165/Rapid_inhibitory_effect_of_corticosterone_on_histamine_release_from_rat_peritoneal_mast_cells_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-973809 DB - PRIME DP - Unbound Medicine ER -