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Receptor mechanisms mediating non-genomic actions of sex steroids.
Semin Reprod Med. 2007 May; 25(3):139-53.SR

Abstract

Sex steroid hormones, including estrogen, progesterone, and androgen, mediate their biological effects on cell proliferation, differentiation, and homeostasis through their respective nuclear receptors. In addition to functioning as ligand-activated nuclear transcription factors to regulate gene transcription, these receptors also have been shown to mediate rapid activation of non-genomic signaling pathways independent of their transcriptional activity. Despite the fact that non-genomic effects of sex steroids have been observed since more than three decades ago, the receptor mechanisms mediating these rapid effects still are not well understood. A subpopulation of nuclear steroid receptors localized to the cell membrane or cytoplasm has been proposed to mediate steroid hormone activation of signaling pathways; however, novel membrane receptors unrelated to nuclear receptors have also been implicated. This review focuses on recent advances in our understanding of the nature of the receptors and mechanisms responsible for rapid non-genomic signaling actions of sex steroids, including novel membrane receptors and interactions of nuclear steroid receptors with membrane and cytoplasmic signaling molecules such as adapter proteins, G proteins, ion channels, and protein kinases. A better definition of receptor mechanisms involved in mediating activation of non-genomic signaling pathways is important to our overall understanding of the biology of steroid hormones.

Authors+Show Affiliations

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. virojb@bcm.tmc.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17447204

Citation

Boonyaratanakornkit, Viroj, and Dean P. Edwards. "Receptor Mechanisms Mediating Non-genomic Actions of Sex Steroids." Seminars in Reproductive Medicine, vol. 25, no. 3, 2007, pp. 139-53.
Boonyaratanakornkit V, Edwards DP. Receptor mechanisms mediating non-genomic actions of sex steroids. Semin Reprod Med. 2007;25(3):139-53.
Boonyaratanakornkit, V., & Edwards, D. P. (2007). Receptor mechanisms mediating non-genomic actions of sex steroids. Seminars in Reproductive Medicine, 25(3), 139-53.
Boonyaratanakornkit V, Edwards DP. Receptor Mechanisms Mediating Non-genomic Actions of Sex Steroids. Semin Reprod Med. 2007;25(3):139-53. PubMed PMID: 17447204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Receptor mechanisms mediating non-genomic actions of sex steroids. AU - Boonyaratanakornkit,Viroj, AU - Edwards,Dean P, PY - 2007/4/21/pubmed PY - 2007/6/1/medline PY - 2007/4/21/entrez SP - 139 EP - 53 JF - Seminars in reproductive medicine JO - Semin Reprod Med VL - 25 IS - 3 N2 - Sex steroid hormones, including estrogen, progesterone, and androgen, mediate their biological effects on cell proliferation, differentiation, and homeostasis through their respective nuclear receptors. In addition to functioning as ligand-activated nuclear transcription factors to regulate gene transcription, these receptors also have been shown to mediate rapid activation of non-genomic signaling pathways independent of their transcriptional activity. Despite the fact that non-genomic effects of sex steroids have been observed since more than three decades ago, the receptor mechanisms mediating these rapid effects still are not well understood. A subpopulation of nuclear steroid receptors localized to the cell membrane or cytoplasm has been proposed to mediate steroid hormone activation of signaling pathways; however, novel membrane receptors unrelated to nuclear receptors have also been implicated. This review focuses on recent advances in our understanding of the nature of the receptors and mechanisms responsible for rapid non-genomic signaling actions of sex steroids, including novel membrane receptors and interactions of nuclear steroid receptors with membrane and cytoplasmic signaling molecules such as adapter proteins, G proteins, ion channels, and protein kinases. A better definition of receptor mechanisms involved in mediating activation of non-genomic signaling pathways is important to our overall understanding of the biology of steroid hormones. SN - 1526-8004 UR - https://www.unboundmedicine.com/medline/citation/17447204/Receptor_mechanisms_mediating_non_genomic_actions_of_sex_steroids_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-973427 DB - PRIME DP - Unbound Medicine ER -