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Breast carcinoma with basal differentiation: a proposal for pathology definition based on basal cytokeratin expression.
Histopathology. 2007 Mar; 50(4):434-8.H

Abstract

AIM

To assess the expression and coexpression of a range of different biomarkers that have been used to define breast carcinomas with a basal phenotype (BP) and their relationship with prognosis in an attempt to refine the definition of BP and to evaluate the reliability of using a single biomarker to identify these tumours.

METHODS AND RESULTS

The expression pattern of basal cytokeratins (CK5/6 and CK14), oestrogen, progesterone and androgen receptors, epidermal growth factor receptor, HER2, BRCA1, P-cadherin and myoepithelial markers (smooth muscle actin and p63) were studied in a well-characterized series of invasive breast carcinoma (1872 cases) with long-term follow-up using immunohistochemistry and tissue microarray. Although the additional markers were associated with basal CK expression, they did not serve to improve recognition of cases with differing outcome when compared with basal CKs alone and, if used to define cases, reduced considerably the proportion of cases allocated to this poor prognostic type of breast cancer.

CONCLUSION

BP can be defined based on the expression of basal CKs regardless of the expression of other markers.

Authors+Show Affiliations

Molecular Medical Sciences, University of Nottingham and Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17448018

Citation

Rakha, E A., et al. "Breast Carcinoma With Basal Differentiation: a Proposal for Pathology Definition Based On Basal Cytokeratin Expression." Histopathology, vol. 50, no. 4, 2007, pp. 434-8.
Rakha EA, El-Sayed ME, Green AR, et al. Breast carcinoma with basal differentiation: a proposal for pathology definition based on basal cytokeratin expression. Histopathology. 2007;50(4):434-8.
Rakha, E. A., El-Sayed, M. E., Green, A. R., Paish, E. C., Lee, A. H., & Ellis, I. O. (2007). Breast carcinoma with basal differentiation: a proposal for pathology definition based on basal cytokeratin expression. Histopathology, 50(4), 434-8.
Rakha EA, et al. Breast Carcinoma With Basal Differentiation: a Proposal for Pathology Definition Based On Basal Cytokeratin Expression. Histopathology. 2007;50(4):434-8. PubMed PMID: 17448018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast carcinoma with basal differentiation: a proposal for pathology definition based on basal cytokeratin expression. AU - Rakha,E A, AU - El-Sayed,M E, AU - Green,A R, AU - Paish,E C, AU - Lee,A H S, AU - Ellis,I O, PY - 2007/4/24/pubmed PY - 2007/5/26/medline PY - 2007/4/24/entrez SP - 434 EP - 8 JF - Histopathology JO - Histopathology VL - 50 IS - 4 N2 - AIM: To assess the expression and coexpression of a range of different biomarkers that have been used to define breast carcinomas with a basal phenotype (BP) and their relationship with prognosis in an attempt to refine the definition of BP and to evaluate the reliability of using a single biomarker to identify these tumours. METHODS AND RESULTS: The expression pattern of basal cytokeratins (CK5/6 and CK14), oestrogen, progesterone and androgen receptors, epidermal growth factor receptor, HER2, BRCA1, P-cadherin and myoepithelial markers (smooth muscle actin and p63) were studied in a well-characterized series of invasive breast carcinoma (1872 cases) with long-term follow-up using immunohistochemistry and tissue microarray. Although the additional markers were associated with basal CK expression, they did not serve to improve recognition of cases with differing outcome when compared with basal CKs alone and, if used to define cases, reduced considerably the proportion of cases allocated to this poor prognostic type of breast cancer. CONCLUSION: BP can be defined based on the expression of basal CKs regardless of the expression of other markers. SN - 0309-0167 UR - https://www.unboundmedicine.com/medline/citation/17448018/Breast_carcinoma_with_basal_differentiation:_a_proposal_for_pathology_definition_based_on_basal_cytokeratin_expression_ L2 - https://doi.org/10.1111/j.1365-2559.2007.02638.x DB - PRIME DP - Unbound Medicine ER -