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The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Anaesthesia. 2007 May; 62(5):446-50.A

Abstract

The optimal dose of remifentanil needed to produce successful intubating conditions following inhalation induction of anaesthesia using 5% sevoflurane without the use of neuromuscular blocking drugs, was investigated in 25 children aged 3-10 years. Sixty seconds after inhalation induction of anaesthesia using sevoflurane 5% in 100% oxygen, a predetermined dose of remifentanil was injected over 30 s. The dose of remifentanil was determined using the modified Dixon's up-and-down method (0.2 microg x kg(-1) as a step size). The first patient was tested at 1.0 microg x kg(-1) remifentanil. Ninety seconds following the bolus administration of remifentanil, the child's trachea was intubated. The optimal bolus dose of remifentanil required for successful tracheal intubation was 0.56 (0.15) microg x kg(-1) in 50% of children during inhalation induction using 5% sevoflurane in the absence of neuromuscular blocking drugs. Using probit analysis, the 95% effective dose (ED(95)) of remifentanil was 0.75 microg x kg(-1) (95% confidence limits 0.63-1.38 microg x kg(-1)).

Authors+Show Affiliations

Department of Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17448054

Citation

Min, S K., et al. "The Optimal Dose of Remifentanil for Intubation During Sevoflurane Induction Without Neuromuscular Blockade in Children." Anaesthesia, vol. 62, no. 5, 2007, pp. 446-50.
Min SK, Kwak YL, Park SY, et al. The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children. Anaesthesia. 2007;62(5):446-50.
Min, S. K., Kwak, Y. L., Park, S. Y., Kim, J. S., & Kim, J. Y. (2007). The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children. Anaesthesia, 62(5), 446-50.
Min SK, et al. The Optimal Dose of Remifentanil for Intubation During Sevoflurane Induction Without Neuromuscular Blockade in Children. Anaesthesia. 2007;62(5):446-50. PubMed PMID: 17448054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children. AU - Min,S K, AU - Kwak,Y L, AU - Park,S Y, AU - Kim,J S, AU - Kim,J Y, PY - 2007/4/24/pubmed PY - 2007/6/8/medline PY - 2007/4/24/entrez SP - 446 EP - 50 JF - Anaesthesia JO - Anaesthesia VL - 62 IS - 5 N2 - The optimal dose of remifentanil needed to produce successful intubating conditions following inhalation induction of anaesthesia using 5% sevoflurane without the use of neuromuscular blocking drugs, was investigated in 25 children aged 3-10 years. Sixty seconds after inhalation induction of anaesthesia using sevoflurane 5% in 100% oxygen, a predetermined dose of remifentanil was injected over 30 s. The dose of remifentanil was determined using the modified Dixon's up-and-down method (0.2 microg x kg(-1) as a step size). The first patient was tested at 1.0 microg x kg(-1) remifentanil. Ninety seconds following the bolus administration of remifentanil, the child's trachea was intubated. The optimal bolus dose of remifentanil required for successful tracheal intubation was 0.56 (0.15) microg x kg(-1) in 50% of children during inhalation induction using 5% sevoflurane in the absence of neuromuscular blocking drugs. Using probit analysis, the 95% effective dose (ED(95)) of remifentanil was 0.75 microg x kg(-1) (95% confidence limits 0.63-1.38 microg x kg(-1)). SN - 0003-2409 UR - https://www.unboundmedicine.com/medline/citation/17448054/The_optimal_dose_of_remifentanil_for_intubation_during_sevoflurane_induction_without_neuromuscular_blockade_in_children_ L2 - https://doi.org/10.1111/j.1365-2044.2007.05037.x DB - PRIME DP - Unbound Medicine ER -