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[Relationship between clinical manifestations and renal pathology in children with Henoch-Schonlein purpura nephritis].
Zhongguo Dang Dai Er Ke Za Zhi. 2007 Apr; 9(2):129-32.ZD

Abstract

OBJECTIVE

This study investigated the clinical manifestations and renal pathological findings of 95 children with Henoch-Schonlein purpura nephritis (HSPN) in order to explore the relationship between clinical manifestations and renal pathology in HSPN.

METHODS

According to clinical manifestations, 95 HSP patients were classified into six clinical groups: 1) normal urine analysis; 2) isolated hematuria or proteinuria; 3) proteinuria with hematuria; 4) acute nephritis; 5) nephrotic syndrome; 6) acute nephritis with over 50 mg/(kg.d) of proteinuria. The severity of the renal pathological findings was determined based on the classification of the International Study of Kidney Disease (ISKDC), including grades I-VI. The relationship between clinical manifestations and the severity of renal pathological findings was studied.

RESULTS

Nephrotic syndrome was the most common clinical diagnosis (26 cases), followed by proteinuria with hematuria (23 cases), normal urine analysis (20 cases), isolated hematuria or proteinuria (15 cases), acute nephritis with over 50 mg/(kg.d) of proteinuria (7 cases) and acute nephritis (4 cases). Twenty-five out of 26 patients with nephrotic syndrome had an ISKDC classification of grade III-IV. All of the four patients with acute nephrits had a classification of grade IIIb. The 7 cases of acute nephritis with over 50 mg/(kg.d) of proteinuria had a classification of grade IIIa-V. The 20 patients with normal urine analysis had a classification of grade Iia- IIIb. There were no significant differences in ISKDC classification among the patients with normal urine analysis, isolated hematuria or proteinuria, and hematuria plus proteinuria. As the course progressed, the degree of renal pathological changes in patients with isolated hematuria or proteinuria and hematuria plus proteinuria became more serious. Of all the 95 patients, 58% had co-deposition of immunoglobulins A, G and M. The percentage of co-deposition of immunoglobulins A, G and M was related to the disease course and the severity of renal pathological findings.

CONCLUSIONS

HSPN children with nephrotic syndrome or acute nephritis with or without proteinuria had relatively severe renal pathological changes. The clinical manifestations were not always in parallel with the severity of renal pathological findings in HSPN children. With the course progressing, the renal pathological changes tended to be serious. The severe renal pathological manifestations came with co-deposition of immunogolobulins A, G and M in the glomerulin.

Authors+Show Affiliations

Laboratory of Pediatric Nephrology, Second Xiangya Hospital of Central South University, Changsha, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17448308

Citation

Zhang, Guo-Zhen, et al. "[Relationship Between Clinical Manifestations and Renal Pathology in Children With Henoch-Schonlein Purpura Nephritis]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 9, no. 2, 2007, pp. 129-32.
Zhang GZ, Wu XC, Yi H, et al. [Relationship between clinical manifestations and renal pathology in children with Henoch-Schonlein purpura nephritis]. Zhongguo Dang Dai Er Ke Za Zhi. 2007;9(2):129-32.
Zhang, G. Z., Wu, X. C., Yi, H., Peng, X. J., Dang, X. Q., He, X. J., & Yi, Z. W. (2007). [Relationship between clinical manifestations and renal pathology in children with Henoch-Schonlein purpura nephritis]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 9(2), 129-32.
Zhang GZ, et al. [Relationship Between Clinical Manifestations and Renal Pathology in Children With Henoch-Schonlein Purpura Nephritis]. Zhongguo Dang Dai Er Ke Za Zhi. 2007;9(2):129-32. PubMed PMID: 17448308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between clinical manifestations and renal pathology in children with Henoch-Schonlein purpura nephritis]. AU - Zhang,Guo-Zhen, AU - Wu,Xiao-Chuan, AU - Yi,Hong, AU - Peng,Xiao-Jie, AU - Dang,Xi-Qiang, AU - He,Xiao-Jie, AU - Yi,Zhu-Wen, PY - 2007/4/24/pubmed PY - 2007/5/12/medline PY - 2007/4/24/entrez SP - 129 EP - 32 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 9 IS - 2 N2 - OBJECTIVE: This study investigated the clinical manifestations and renal pathological findings of 95 children with Henoch-Schonlein purpura nephritis (HSPN) in order to explore the relationship between clinical manifestations and renal pathology in HSPN. METHODS: According to clinical manifestations, 95 HSP patients were classified into six clinical groups: 1) normal urine analysis; 2) isolated hematuria or proteinuria; 3) proteinuria with hematuria; 4) acute nephritis; 5) nephrotic syndrome; 6) acute nephritis with over 50 mg/(kg.d) of proteinuria. The severity of the renal pathological findings was determined based on the classification of the International Study of Kidney Disease (ISKDC), including grades I-VI. The relationship between clinical manifestations and the severity of renal pathological findings was studied. RESULTS: Nephrotic syndrome was the most common clinical diagnosis (26 cases), followed by proteinuria with hematuria (23 cases), normal urine analysis (20 cases), isolated hematuria or proteinuria (15 cases), acute nephritis with over 50 mg/(kg.d) of proteinuria (7 cases) and acute nephritis (4 cases). Twenty-five out of 26 patients with nephrotic syndrome had an ISKDC classification of grade III-IV. All of the four patients with acute nephrits had a classification of grade IIIb. The 7 cases of acute nephritis with over 50 mg/(kg.d) of proteinuria had a classification of grade IIIa-V. The 20 patients with normal urine analysis had a classification of grade Iia- IIIb. There were no significant differences in ISKDC classification among the patients with normal urine analysis, isolated hematuria or proteinuria, and hematuria plus proteinuria. As the course progressed, the degree of renal pathological changes in patients with isolated hematuria or proteinuria and hematuria plus proteinuria became more serious. Of all the 95 patients, 58% had co-deposition of immunoglobulins A, G and M. The percentage of co-deposition of immunoglobulins A, G and M was related to the disease course and the severity of renal pathological findings. CONCLUSIONS: HSPN children with nephrotic syndrome or acute nephritis with or without proteinuria had relatively severe renal pathological changes. The clinical manifestations were not always in parallel with the severity of renal pathological findings in HSPN children. With the course progressing, the renal pathological changes tended to be serious. The severe renal pathological manifestations came with co-deposition of immunogolobulins A, G and M in the glomerulin. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/17448308/[Relationship_between_clinical_manifestations_and_renal_pathology_in_children_with_Henoch_Schonlein_purpura_nephritis]_ L2 - http://www.diseaseinfosearch.org/result/3323 DB - PRIME DP - Unbound Medicine ER -