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Update on non-alcoholic fatty liver disease in children.
Clin Nutr. 2007 Aug; 26(4):409-15.CN

Abstract

Non-alcoholic fatty liver disease (NAFLD) is probably the most common cause of liver disease in the pediatric community. It is closely associated with obesity and insulin resistance. NAFLD may lead to non-alcoholic steatohepatitis (NASH). Although NASH is a prerequisite for the definition of NAFLD in adults and children, distinct differences are often apparent in the extent or location of fat, inflammation and fibrosis. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies; however, staging the disease requires a liver biopsy. Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and medications appear promising. The aim of this review is to summarize what is known about pediatric NAFLD in terms of prevalence, pathogenesis, diagnosis, histology and treatment.

Authors+Show Affiliations

2nd Department of Pediatrics, Aristotle University of Thessaloniki, School of Medicine, St Kiriakidi 1 Thessalonki, Greece. vellada@otenet.grNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17449148

Citation

Papandreou, Dimitrios, et al. "Update On Non-alcoholic Fatty Liver Disease in Children." Clinical Nutrition (Edinburgh, Scotland), vol. 26, no. 4, 2007, pp. 409-15.
Papandreou D, Rousso I, Mavromichalis I. Update on non-alcoholic fatty liver disease in children. Clin Nutr. 2007;26(4):409-15.
Papandreou, D., Rousso, I., & Mavromichalis, I. (2007). Update on non-alcoholic fatty liver disease in children. Clinical Nutrition (Edinburgh, Scotland), 26(4), 409-15.
Papandreou D, Rousso I, Mavromichalis I. Update On Non-alcoholic Fatty Liver Disease in Children. Clin Nutr. 2007;26(4):409-15. PubMed PMID: 17449148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Update on non-alcoholic fatty liver disease in children. AU - Papandreou,Dimitrios, AU - Rousso,Israel, AU - Mavromichalis,Ioannis, Y1 - 2007/04/20/ PY - 2006/09/14/received PY - 2007/01/17/revised PY - 2007/02/19/accepted PY - 2007/4/24/pubmed PY - 2007/10/24/medline PY - 2007/4/24/entrez SP - 409 EP - 15 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 26 IS - 4 N2 - Non-alcoholic fatty liver disease (NAFLD) is probably the most common cause of liver disease in the pediatric community. It is closely associated with obesity and insulin resistance. NAFLD may lead to non-alcoholic steatohepatitis (NASH). Although NASH is a prerequisite for the definition of NAFLD in adults and children, distinct differences are often apparent in the extent or location of fat, inflammation and fibrosis. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies; however, staging the disease requires a liver biopsy. Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and medications appear promising. The aim of this review is to summarize what is known about pediatric NAFLD in terms of prevalence, pathogenesis, diagnosis, histology and treatment. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/17449148/Update_on_non_alcoholic_fatty_liver_disease_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(07)00041-6 DB - PRIME DP - Unbound Medicine ER -