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Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery.
Am J Physiol Heart Circ Physiol. 2007 Aug; 293(2):H1031-7.AJ

Abstract

BACKGROUND

Previous clinical studies have observed relationships between increased intima-media thickness (IMT) in the carotid artery, elevated blood pressure, and low wall shear stress (WSS) calculated from the Poiseuille equation. This study used numerical methods to more accurately determine WSS in the carotid artery and to investigate possible determinants of increased IMT.

METHODS

IMT [common carotid artery (CCA) and bulb], CCA flow velocity, brachial systolic (SBP) and diastolic blood pressure (DBP), and carotid systolic pressure (cSBP) were measured in 14 healthy subjects (aged 44 +/- 16 yr). Flow patterns in the carotid bifurcation were determined by computational fluid dynamics (CFD) based on three-dimensional ultrasound geometry. Instantaneous and time-averaged wall shear stress (WSS(av)), oscillatory shear index (OSI), and wall shear stress angle gradients (WSSAG) were calculated.

RESULTS

IMT was positively related to SBP, DBP, cSBP, and WSSAG and inversely related to WSS(av) in the CCA. In the bulb, IMT was positively related to SBP and cSBP but was not significantly related to WSS(av) or WSSAG. IMT was unrelated to OSI in both the CCA and the bulb.

CONCLUSION

Increased carotid artery IMT in healthy subjects with no evidence of focal plaques is primarily a response to elevated pressure.

Authors+Show Affiliations

Department of Chemical Engineering, Faculty of Engineering, Imperial College London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17449549

Citation

Augst, A D., et al. "Analysis of Complex Flow and the Relationship Between Blood Pressure, Wall Shear Stress, and Intima-media Thickness in the Human Carotid Artery." American Journal of Physiology. Heart and Circulatory Physiology, vol. 293, no. 2, 2007, pp. H1031-7.
Augst AD, Ariff B, McG Thom SA, et al. Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery. Am J Physiol Heart Circ Physiol. 2007;293(2):H1031-7.
Augst, A. D., Ariff, B., McG Thom, S. A., Xu, X. Y., & Hughes, A. D. (2007). Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery. American Journal of Physiology. Heart and Circulatory Physiology, 293(2), H1031-7.
Augst AD, et al. Analysis of Complex Flow and the Relationship Between Blood Pressure, Wall Shear Stress, and Intima-media Thickness in the Human Carotid Artery. Am J Physiol Heart Circ Physiol. 2007;293(2):H1031-7. PubMed PMID: 17449549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery. AU - Augst,A D, AU - Ariff,B, AU - McG Thom,S A G, AU - Xu,X Y, AU - Hughes,A D, Y1 - 2007/04/20/ PY - 2007/4/24/pubmed PY - 2007/9/19/medline PY - 2007/4/24/entrez SP - H1031 EP - 7 JF - American journal of physiology. Heart and circulatory physiology JO - Am J Physiol Heart Circ Physiol VL - 293 IS - 2 N2 - BACKGROUND: Previous clinical studies have observed relationships between increased intima-media thickness (IMT) in the carotid artery, elevated blood pressure, and low wall shear stress (WSS) calculated from the Poiseuille equation. This study used numerical methods to more accurately determine WSS in the carotid artery and to investigate possible determinants of increased IMT. METHODS: IMT [common carotid artery (CCA) and bulb], CCA flow velocity, brachial systolic (SBP) and diastolic blood pressure (DBP), and carotid systolic pressure (cSBP) were measured in 14 healthy subjects (aged 44 +/- 16 yr). Flow patterns in the carotid bifurcation were determined by computational fluid dynamics (CFD) based on three-dimensional ultrasound geometry. Instantaneous and time-averaged wall shear stress (WSS(av)), oscillatory shear index (OSI), and wall shear stress angle gradients (WSSAG) were calculated. RESULTS: IMT was positively related to SBP, DBP, cSBP, and WSSAG and inversely related to WSS(av) in the CCA. In the bulb, IMT was positively related to SBP and cSBP but was not significantly related to WSS(av) or WSSAG. IMT was unrelated to OSI in both the CCA and the bulb. CONCLUSION: Increased carotid artery IMT in healthy subjects with no evidence of focal plaques is primarily a response to elevated pressure. SN - 0363-6135 UR - https://www.unboundmedicine.com/medline/citation/17449549/Analysis_of_complex_flow_and_the_relationship_between_blood_pressure_wall_shear_stress_and_intima_media_thickness_in_the_human_carotid_artery_ L2 - https://journals.physiology.org/doi/10.1152/ajpheart.00989.2006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -