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Thermal and visceral hypersensitivity in irritable bowel syndrome patients with and without fibromyalgia.
Clin J Pain. 2007 May; 23(4):323-30.CJ

Abstract

BACKGROUND

Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by both visceral and somatic hyperalgesia, producing a similar effect seen with the central hypersensitivity mechanism in fibromyalgia (FM).

OBJECTIVES

The aim of the current study was to compare magnitudes of visceral and thermal hypersensitivity in IBS patients and FM patients with IBS (FM+IBS) compared with healthy controls.

METHODS

Female patients with IBS (n=12), FM+IBS (n=12), and control participants (n=13) rated pain intensity to hot water immersion (45 and 47 degrees C) of the hand/foot and to phasic distension of the rectum (35, 55 mm Hg) on a Mechanical Visual Analog Scale. The data were analyzed with 3 separate 1-way analyses of variance with post hoc Tukey tests.

RESULTS

For both thermal and visceral stimuli, the control group had lower pain ratings than either the IBS or FM+IBS groups (P<0.001). IBS patients rated rectal distension as more painful than the FM+IBS group (P=0.005). During hot water immersion of the foot, the FM+IBS group had higher pain ratings than the IBS group (P<0.001). During hand immersion, FM+IBS and IBS patients did not significantly differ in their pain intensity ratings (P=0.4).

CONCLUSIONS

FM+IBS patients show greater thermal hypersensitivity compared with IBS patients. However, IBS patients exhibit higher pain ratings to rectal distension compared with FM+IBS patients. This data suggests that regions of primary and secondary hyperalgesia are dependent on the primary pain complaint.

Authors+Show Affiliations

Department of Medicine, University of Florida Colleges of Medicine, Dentistry, Public Health and Health Professions, Gainesville, FL 32610-0214, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17449993

Citation

Moshiree, Baharak, et al. "Thermal and Visceral Hypersensitivity in Irritable Bowel Syndrome Patients With and Without Fibromyalgia." The Clinical Journal of Pain, vol. 23, no. 4, 2007, pp. 323-30.
Moshiree B, Price DD, Robinson ME, et al. Thermal and visceral hypersensitivity in irritable bowel syndrome patients with and without fibromyalgia. Clin J Pain. 2007;23(4):323-30.
Moshiree, B., Price, D. D., Robinson, M. E., Gaible, R., & Verne, G. N. (2007). Thermal and visceral hypersensitivity in irritable bowel syndrome patients with and without fibromyalgia. The Clinical Journal of Pain, 23(4), 323-30.
Moshiree B, et al. Thermal and Visceral Hypersensitivity in Irritable Bowel Syndrome Patients With and Without Fibromyalgia. Clin J Pain. 2007;23(4):323-30. PubMed PMID: 17449993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thermal and visceral hypersensitivity in irritable bowel syndrome patients with and without fibromyalgia. AU - Moshiree,Baharak, AU - Price,Donald D, AU - Robinson,Michael E, AU - Gaible,Ryan, AU - Verne,G Nicholas, PY - 2007/4/24/pubmed PY - 2007/7/19/medline PY - 2007/4/24/entrez SP - 323 EP - 30 JF - The Clinical journal of pain JO - Clin J Pain VL - 23 IS - 4 N2 - BACKGROUND: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by both visceral and somatic hyperalgesia, producing a similar effect seen with the central hypersensitivity mechanism in fibromyalgia (FM). OBJECTIVES: The aim of the current study was to compare magnitudes of visceral and thermal hypersensitivity in IBS patients and FM patients with IBS (FM+IBS) compared with healthy controls. METHODS: Female patients with IBS (n=12), FM+IBS (n=12), and control participants (n=13) rated pain intensity to hot water immersion (45 and 47 degrees C) of the hand/foot and to phasic distension of the rectum (35, 55 mm Hg) on a Mechanical Visual Analog Scale. The data were analyzed with 3 separate 1-way analyses of variance with post hoc Tukey tests. RESULTS: For both thermal and visceral stimuli, the control group had lower pain ratings than either the IBS or FM+IBS groups (P<0.001). IBS patients rated rectal distension as more painful than the FM+IBS group (P=0.005). During hot water immersion of the foot, the FM+IBS group had higher pain ratings than the IBS group (P<0.001). During hand immersion, FM+IBS and IBS patients did not significantly differ in their pain intensity ratings (P=0.4). CONCLUSIONS: FM+IBS patients show greater thermal hypersensitivity compared with IBS patients. However, IBS patients exhibit higher pain ratings to rectal distension compared with FM+IBS patients. This data suggests that regions of primary and secondary hyperalgesia are dependent on the primary pain complaint. SN - 0749-8047 UR - https://www.unboundmedicine.com/medline/citation/17449993/Thermal_and_visceral_hypersensitivity_in_irritable_bowel_syndrome_patients_with_and_without_fibromyalgia_ L2 - https://doi.org/10.1097/AJP.0b013e318032e496 DB - PRIME DP - Unbound Medicine ER -