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Breastfeeding and risk of ovarian cancer in two prospective cohorts.

Abstract

OBJECTIVE

To describe the association between breastfeeding and ovarian cancer risk in two prospective cohorts.

MATERIALS & METHODS

We pooled data from the Nurses' Health Study and Nurses' Health Study II. There were 391 cases of epithelial ovarian cancer diagnosed among 149,693 parous women with up to 16 years of follow-up. Data were analyzed using multivariate Cox proportional hazards models, controlling for age, parity, duration of oral contraceptive use, tubal ligation, and age at menarche.

RESULTS

Ever breastfeeding was associated with a non-significant reduction in ovarian cancer risk compared with never breastfeeding (RR=0.86, 95% CI 0.70-1.06); the median duration of breastfeeding among women who breastfed was nine months. Breastfeeding of 18 or more months was associated with a significant decrease in ovarian cancer risk compared to never breastfeeding (RR=0.66, 95% CI 0.46-0.96). For each month of breastfeeding the relative risk decreased by 2% (RR=0.98 per month, 95% CI 0.97-1.00).

CONCLUSIONS

These data support a linear inverse association between breastfeeding and risk of epithelial ovarian cancer.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA. kim.danforth@channing.harvard.edu

    , , , ,

    Source

    Cancer causes & control : CCC 18:5 2007 Jun pg 517-23

    MeSH

    Adult
    Breast Feeding
    Cohort Studies
    Female
    Humans
    Middle Aged
    Ovarian Neoplasms
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17450440

    Citation

    Danforth, Kim N., et al. "Breastfeeding and Risk of Ovarian Cancer in Two Prospective Cohorts." Cancer Causes & Control : CCC, vol. 18, no. 5, 2007, pp. 517-23.
    Danforth KN, Tworoger SS, Hecht JL, et al. Breastfeeding and risk of ovarian cancer in two prospective cohorts. Cancer Causes Control. 2007;18(5):517-23.
    Danforth, K. N., Tworoger, S. S., Hecht, J. L., Rosner, B. A., Colditz, G. A., & Hankinson, S. E. (2007). Breastfeeding and risk of ovarian cancer in two prospective cohorts. Cancer Causes & Control : CCC, 18(5), pp. 517-23.
    Danforth KN, et al. Breastfeeding and Risk of Ovarian Cancer in Two Prospective Cohorts. Cancer Causes Control. 2007;18(5):517-23. PubMed PMID: 17450440.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Breastfeeding and risk of ovarian cancer in two prospective cohorts. AU - Danforth,Kim N, AU - Tworoger,Shelley S, AU - Hecht,Jonathan L, AU - Rosner,Bernard A, AU - Colditz,Graham A, AU - Hankinson,Susan E, Y1 - 2007/04/21/ PY - 2006/10/04/received PY - 2007/02/16/accepted PY - 2007/4/24/pubmed PY - 2007/9/12/medline PY - 2007/4/24/entrez SP - 517 EP - 23 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 18 IS - 5 N2 - OBJECTIVE: To describe the association between breastfeeding and ovarian cancer risk in two prospective cohorts. MATERIALS & METHODS: We pooled data from the Nurses' Health Study and Nurses' Health Study II. There were 391 cases of epithelial ovarian cancer diagnosed among 149,693 parous women with up to 16 years of follow-up. Data were analyzed using multivariate Cox proportional hazards models, controlling for age, parity, duration of oral contraceptive use, tubal ligation, and age at menarche. RESULTS: Ever breastfeeding was associated with a non-significant reduction in ovarian cancer risk compared with never breastfeeding (RR=0.86, 95% CI 0.70-1.06); the median duration of breastfeeding among women who breastfed was nine months. Breastfeeding of 18 or more months was associated with a significant decrease in ovarian cancer risk compared to never breastfeeding (RR=0.66, 95% CI 0.46-0.96). For each month of breastfeeding the relative risk decreased by 2% (RR=0.98 per month, 95% CI 0.97-1.00). CONCLUSIONS: These data support a linear inverse association between breastfeeding and risk of epithelial ovarian cancer. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17450440/Breastfeeding_and_risk_of_ovarian_cancer_in_two_prospective_cohorts_ L2 - https://doi.org/10.1007/s10552-007-0130-2 DB - PRIME DP - Unbound Medicine ER -