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The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons.
Biochem Biophys Res Commun. 2007 Jun 08; 357(3):579-83.BB

Abstract

In this paper, we investigated the action of huwentoxin-I (HWTX-I) purified from the venom of the Chinese bird spider Ornithoctonus huwena on Ca(2+), Na(+) channels of adult rat dorsal root ganglion (DRG) neurons. The results showed that huwentoxin-I could reduce the peak currents of N-type Ca(2+) channels (IC(50) approximately 100 nM) and TTX-S Na(+) channels (IC(50) approximately 55 nM), whereas no effect was detected on TTX-R Na(+) channels. The comparative studies indicated that the selectivity of HWTX-I on Ca(2+) channels was higher that of MVIIA and approximately the same as that of GVIA. HWTX-I is the first discovered toxin with the cross channel activities from the spider O. huwena venom similar to micro O-conotoxins MrVIA and MrVIB.

Authors+Show Affiliations

Key Laboratory of Protein Chemistry and Developmental Biology of Education, The College of Life Science, Hunan Normal University, Changsha 410081, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17451655

Citation

Wang, Meichi, et al. "The Cross Channel Activities of Spider Neurotoxin huwentoxin-I On Rat Dorsal Root Ganglion Neurons." Biochemical and Biophysical Research Communications, vol. 357, no. 3, 2007, pp. 579-83.
Wang M, Guan X, Liang S. The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons. Biochem Biophys Res Commun. 2007;357(3):579-83.
Wang, M., Guan, X., & Liang, S. (2007). The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons. Biochemical and Biophysical Research Communications, 357(3), 579-83.
Wang M, Guan X, Liang S. The Cross Channel Activities of Spider Neurotoxin huwentoxin-I On Rat Dorsal Root Ganglion Neurons. Biochem Biophys Res Commun. 2007 Jun 8;357(3):579-83. PubMed PMID: 17451655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons. AU - Wang,Meichi, AU - Guan,Xin, AU - Liang,Songping, Y1 - 2007/04/09/ PY - 2007/02/13/received PY - 2007/02/16/accepted PY - 2007/4/25/pubmed PY - 2007/7/13/medline PY - 2007/4/25/entrez SP - 579 EP - 83 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 357 IS - 3 N2 - In this paper, we investigated the action of huwentoxin-I (HWTX-I) purified from the venom of the Chinese bird spider Ornithoctonus huwena on Ca(2+), Na(+) channels of adult rat dorsal root ganglion (DRG) neurons. The results showed that huwentoxin-I could reduce the peak currents of N-type Ca(2+) channels (IC(50) approximately 100 nM) and TTX-S Na(+) channels (IC(50) approximately 55 nM), whereas no effect was detected on TTX-R Na(+) channels. The comparative studies indicated that the selectivity of HWTX-I on Ca(2+) channels was higher that of MVIIA and approximately the same as that of GVIA. HWTX-I is the first discovered toxin with the cross channel activities from the spider O. huwena venom similar to micro O-conotoxins MrVIA and MrVIB. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/17451655/The_cross_channel_activities_of_spider_neurotoxin_huwentoxin_I_on_rat_dorsal_root_ganglion_neurons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(07)00373-7 DB - PRIME DP - Unbound Medicine ER -