Tags

Type your tag names separated by a space and hit enter

Triggering of final oocyte maturation with gonadotropin-releasing hormone agonist or human chorionic gonadotropin. Live birth after frozen-thawed embryo replacement cycles.
Fertil Steril. 2007 Sep; 88(3):616-21.FS

Abstract

OBJECTIVE

To report the outcome of frozen-thawed embryo replacement cycles after GnRH-agonist triggering of final oocyte maturation in the collecting cycle with GnRH-antagonist.

DESIGN

Prospective, observational, multicentric clinical study.

SETTING

Tertiary university-affiliated IVF centers.

PATIENT(S)

Patients under observation previously had been recruited into two concurrently performed, independent, randomized controlled trials (comparing hCG with GnRH-agonist for triggering final oocyte maturation in GnRH-antagonist multiple-dose protocols in normal responder patients) encompassing a total of 228 participants. Surplus embryos or oocytes at the pronuclear stage were cryopreserved in 53 patients after hCG administration and 32 patients after GnRH-agonist administration on the basis of patient choice, pronuclear/embryo availability, and local laws.

INTERVENTION(S)

Transfer of frozen-thawed embryos.

MAIN OUTCOME MEASURE(S)

Live birth rate.

RESULT(S)

Thirty-one and 23 patients after administration of hCG and GnRH-agonist, respectively, started a frozen-embryo replacement cycle by September 2005, with 25 and 16 patients eventually undergoing at least one frozen-thawed ET. Live birth rate per ET was 18.5% (95% confidence interval [CI], 8.2-36.7) and 30.0% (95% CI, 14.5-51.9) after hCG and GnRH-agonist triggering, respectively. Cumulative live birth rate per patient starting a frozen-embryo replacement cycle was 16.1% (95% CI, 7.1-32.6) and 26.1% (95% CI, 12.5-46.5) for hCG and GnRH-agonist, respectively.

CONCLUSION(S)

The likelihood of live birth in frozen-embryo replacement cycles after GnRH-agonist triggering of final oocyte maturation does not appear to be impaired.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. georg.griesinger@frauenklinik.uni-luebeck.de <georg.griesinger@frauenklinik.uni-luebeck.de>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17451691

Citation

Griesinger, Georg, et al. "Triggering of Final Oocyte Maturation With Gonadotropin-releasing Hormone Agonist or Human Chorionic Gonadotropin. Live Birth After Frozen-thawed Embryo Replacement Cycles." Fertility and Sterility, vol. 88, no. 3, 2007, pp. 616-21.
Griesinger G, Kolibianakis EM, Papanikolaou EG, et al. Triggering of final oocyte maturation with gonadotropin-releasing hormone agonist or human chorionic gonadotropin. Live birth after frozen-thawed embryo replacement cycles. Fertil Steril. 2007;88(3):616-21.
Griesinger, G., Kolibianakis, E. M., Papanikolaou, E. G., Diedrich, K., Van Steirteghem, A., Devroey, P., Ejdrup Bredkjaer, H., & Humaidan, P. (2007). Triggering of final oocyte maturation with gonadotropin-releasing hormone agonist or human chorionic gonadotropin. Live birth after frozen-thawed embryo replacement cycles. Fertility and Sterility, 88(3), 616-21.
Griesinger G, et al. Triggering of Final Oocyte Maturation With Gonadotropin-releasing Hormone Agonist or Human Chorionic Gonadotropin. Live Birth After Frozen-thawed Embryo Replacement Cycles. Fertil Steril. 2007;88(3):616-21. PubMed PMID: 17451691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triggering of final oocyte maturation with gonadotropin-releasing hormone agonist or human chorionic gonadotropin. Live birth after frozen-thawed embryo replacement cycles. AU - Griesinger,Georg, AU - Kolibianakis,E M, AU - Papanikolaou,E G, AU - Diedrich,K, AU - Van Steirteghem,A, AU - Devroey,P, AU - Ejdrup Bredkjaer,Helle, AU - Humaidan,Peter, Y1 - 2007/04/23/ PY - 2006/05/17/received PY - 2006/12/04/revised PY - 2006/12/22/accepted PY - 2007/4/25/pubmed PY - 2007/9/26/medline PY - 2007/4/25/entrez SP - 616 EP - 21 JF - Fertility and sterility JO - Fertil Steril VL - 88 IS - 3 N2 - OBJECTIVE: To report the outcome of frozen-thawed embryo replacement cycles after GnRH-agonist triggering of final oocyte maturation in the collecting cycle with GnRH-antagonist. DESIGN: Prospective, observational, multicentric clinical study. SETTING: Tertiary university-affiliated IVF centers. PATIENT(S): Patients under observation previously had been recruited into two concurrently performed, independent, randomized controlled trials (comparing hCG with GnRH-agonist for triggering final oocyte maturation in GnRH-antagonist multiple-dose protocols in normal responder patients) encompassing a total of 228 participants. Surplus embryos or oocytes at the pronuclear stage were cryopreserved in 53 patients after hCG administration and 32 patients after GnRH-agonist administration on the basis of patient choice, pronuclear/embryo availability, and local laws. INTERVENTION(S): Transfer of frozen-thawed embryos. MAIN OUTCOME MEASURE(S): Live birth rate. RESULT(S): Thirty-one and 23 patients after administration of hCG and GnRH-agonist, respectively, started a frozen-embryo replacement cycle by September 2005, with 25 and 16 patients eventually undergoing at least one frozen-thawed ET. Live birth rate per ET was 18.5% (95% confidence interval [CI], 8.2-36.7) and 30.0% (95% CI, 14.5-51.9) after hCG and GnRH-agonist triggering, respectively. Cumulative live birth rate per patient starting a frozen-embryo replacement cycle was 16.1% (95% CI, 7.1-32.6) and 26.1% (95% CI, 12.5-46.5) for hCG and GnRH-agonist, respectively. CONCLUSION(S): The likelihood of live birth in frozen-embryo replacement cycles after GnRH-agonist triggering of final oocyte maturation does not appear to be impaired. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17451691/Triggering_of_final_oocyte_maturation_with_gonadotropin_releasing_hormone_agonist_or_human_chorionic_gonadotropin__Live_birth_after_frozen_thawed_embryo_replacement_cycles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)00032-5 DB - PRIME DP - Unbound Medicine ER -